Understanding phenotypes: contributions from studying mutations in a model organism. The distribution of fish across aquatic habitats will be determined jointly by the swimming speed and endurance requirements imposed by features of the environment, such as water flow, and by the swimming capacity of the fish. This project will use zebrafish to characterise how body shape and physiology interact to determine swimming capacity.
Advanced Interface Technologies for Computational Science & Simulation. The project will research novel computer vision technologies that enable the next generation of visualisation portals for scientific collaboration. The development of new computer vision tools is key to truly natural human-machine interaction. The research outcomes of this project directly align with National Research Priority 3: Frontier Technologies. It supports four of the five relevant priority goals - Breakthrough Scien ....Advanced Interface Technologies for Computational Science & Simulation. The project will research novel computer vision technologies that enable the next generation of visualisation portals for scientific collaboration. The development of new computer vision tools is key to truly natural human-machine interaction. The research outcomes of this project directly align with National Research Priority 3: Frontier Technologies. It supports four of the five relevant priority goals - Breakthrough Science, Frontier Technologies, Smart Information Use, and Promoting an Innovation Culture and Economy. Outcomes of this research are also relevant to Research Priority 4: Safeguarding Australia, and has direct applications to video surveillance technology. Significant commercial opportunities, including licensing and spin-offs exist.Read moreRead less
Statistical Methods for Next Generation Genome-Wide Association Studies. This project aims to develop cutting-edge statistical methods to analyse large genomic datasets and identify genetic variants associated with inter-individual differences in various human traits. Knowledge of trait-associated DNA variants is instrumental in understanding how natural selection has shaped human traits. By integrating genomic data from diverse and underrepresented populations, this project further expects to c ....Statistical Methods for Next Generation Genome-Wide Association Studies. This project aims to develop cutting-edge statistical methods to analyse large genomic datasets and identify genetic variants associated with inter-individual differences in various human traits. Knowledge of trait-associated DNA variants is instrumental in understanding how natural selection has shaped human traits. By integrating genomic data from diverse and underrepresented populations, this project further expects to contribute to the equitable use of genomic technologies in humans, regardless of geographical origins. Expected outcomes of this research include novel analysis methods and software tools, which should broadly and significantly benefit gene discovery in other species, including those of agricultural relevance.Read moreRead less
A new statistical framework to understand the biological basis of Ankylosing Spondylitis and other complex diseases. Ankylosing Spondylitis (AS) is a highly heritable and common inflammatory arthritis which causes stiffness and progressive fusion of the spine, decreased quality of life and reduced lifespan. There is no known cure for the condition. This project aims to identify genes and biological pathways involved in AS pathogenesis using a new statistical framework that will be applied to tho ....A new statistical framework to understand the biological basis of Ankylosing Spondylitis and other complex diseases. Ankylosing Spondylitis (AS) is a highly heritable and common inflammatory arthritis which causes stiffness and progressive fusion of the spine, decreased quality of life and reduced lifespan. There is no known cure for the condition. This project aims to identify genes and biological pathways involved in AS pathogenesis using a new statistical framework that will be applied to thousands of individuals with the disease. This project will improve understanding of the underlying mechanisms involved in AS pathophysiology, inform development of new drug treatments for the condition, and create a powerful new statistical approach that can be used to identify biological pathways which are important in the pathogenesis of other complex diseases.Read moreRead less
Genomic Control of Human Complex Trait Variation. This project aims to address knowledge gaps in our understanding of the genetic and environmental control of complex human trait variation. This project will use innovative approaches that combine molecular genomic information with data from large biobank sized cohorts to generate new knowledge of the mechanisms underlying ancestral and sex differences in humans. Expected outcomes include the development of novel methods for the integrative analy ....Genomic Control of Human Complex Trait Variation. This project aims to address knowledge gaps in our understanding of the genetic and environmental control of complex human trait variation. This project will use innovative approaches that combine molecular genomic information with data from large biobank sized cohorts to generate new knowledge of the mechanisms underlying ancestral and sex differences in humans. Expected outcomes include the development of novel methods for the integrative analysis of genomic data and building Australia’s capacity in a highly demanded field, ensuring the capability to realise the translation of this knowledge to positively impact society and human well-being.Read moreRead less
Developing methods for the analysis of massively parallel sequencing data in family studies. This project will develop analytical methods to use the latest, high-throughput method of generating sequencing data, i.e. the letters of the human genome alphabet. These tools will be used to identify the causal mutations in families with inherited disorders, leading to diagnostic tests for these families.
Elucidating the genetics of attention deficit hyperactivity disorder by integrating pathway and prediction analyses. Attention deficit hyperactivity disorder (ADHD) is the most common psychiatric disorder in children; while treatments are available they are ineffective for many patients. This project will develop methods for predicting genetic effects at the level of the biological mechanism to assist in identifying new drug targets and behavioural interventions.
Sustainability in Computing: A Holistic View. Green computing must provide sustainable processing capabilities with high energy efficiency (lower carbon footprint) and increased product longevity (reducing the need for product replacement). While advances in technology have afforded significant reduction in power requirements, they come with inherent challenges due to uncertainties in micro-scale behaviour, high complexity of quantifying/optimising energy cost or system lifetime in extreme scale ....Sustainability in Computing: A Holistic View. Green computing must provide sustainable processing capabilities with high energy efficiency (lower carbon footprint) and increased product longevity (reducing the need for product replacement). While advances in technology have afforded significant reduction in power requirements, they come with inherent challenges due to uncertainties in micro-scale behaviour, high complexity of quantifying/optimising energy cost or system lifetime in extreme scale computing, and the interaction of non-computing components with individual computing systems. This project addresses these challenges via a holistic, multi-scale paradigm for modelling, analysis, and optimisation of energy cost, carbon footprint, and product lifetime in emerging computing systems.Read moreRead less
Automatic video annotation by learning from web data. This project aims to study next-generation video annotation technologies to automatically tag raw videos using a huge set of semantic concepts. The project will study new domain adaptation schemes and frameworks in order to substantially improve video annotation performance. The resulting prototype system can be directly used by ordinary users worldwide to search their personal videos using textual queries. The system is also applicable to vi ....Automatic video annotation by learning from web data. This project aims to study next-generation video annotation technologies to automatically tag raw videos using a huge set of semantic concepts. The project will study new domain adaptation schemes and frameworks in order to substantially improve video annotation performance. The resulting prototype system can be directly used by ordinary users worldwide to search their personal videos using textual queries. The system is also applicable to video surveillance applications, which can enhance Australia’s homeland security.Read moreRead less
Smart comparison and assessment of prediction models for better health using next generation data mining. Prediction models can be used to provide early warning of events, such as adverse medical outcomes. This project will develop principles for the smart management of large collections of prediction models using data mining, enabling more timely medical interventions for Australians to live healthier and longer.