Mechanisms Of Abnormal Expression Of The IGF2 Gene In Disorders Affectin Foetal Growth
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
The IGF2 gene is crucial for foetal growth. Only the copy inherited from the father is active, a phenomenon named parental imprinting. In some children with foetal overgrowth or growth retardation, the deregulation of imprinting of the IGF2 gene during the first days of foetal development will influence subsequent growth and will also have major implications in post-natal and adult life. We will investigate the mechanisms resulting in abnormal imprinting of IGF2 early in development.
To reduce Australia's future dementia burden, it is imperative to develop methods to identify those Australians at the very early stage of dementia. To achieve this goal, we are establishing multidisciplinary research projects to track disease progression from the very early stage. These projects use cutting-edge neuroscience technologies to examine how the mind and brain change in dementia. My goal is to discover novel methods for early detection, and develop early intervention strategies.
In Australia, over 2,000 families every year have a stillborn child. Each of these deaths places a heavy psychological and financial burden on parents and families and the wider community. Progress in preventing these deaths has been very slow and despite the impact of this loss, the care provided for parents following a stillbirth is often inadequate. I am leading a national research program to reduce stillbirth and improve care for parents when their child is stillborn.
Preventing Complications Of Chronic Obstructive Pulmonary Disease
Funder
National Health and Medical Research Council
Funding Amount
$310,914.00
Summary
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease that affects smokers. Lung complications and complications in other organs occur commonly. This study will examine factors that lead to exacerbations of COPD, and test the effectiveness of early diagnosis of coronary artery disease using CT scans.
Improving Diagnosis Of Early Frontotemporal Dementia Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
Frontotemporal dementia is difficult to identify and diagnose accurately, although it is almost as common as Alzheimer’s disease before the age of 65. Improving its detection and diagnostic accuracy is the focus of my fellowship for the next 4 years. As a neuropsychologist with over 15 years clinical experience in dementia, I will combine clinical, neuroimaging and neuropathological approaches to identify early presentations of frontotemporal dementia and other dementia syndromes.
This research will develop cutting-edge computational tools and statistical methods to analyse, model and visualise the way in which the human brain is interconnected. The tools developed will be used to identify biological markers in the brain’s network of axonal circuitry (the connectome) that are valuable for diagnosis and prognosis of psychiatric disorders. This research will bring to fruition the exciting potential of connectomics in neuroscience and psychiatry.
Patient-specific Modelling Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Cardiovascular disease is undoubtedly the biggest killer in the developed world and accounts for 30% of all deaths in Australia; killing one Australian every twelve minutes. My research group and I, combine medical imaging with biomedical engineering to perform patient-specific modelling. For example, we can predict the likelihood that aneurysm will rupture or the way blood flows through the aorta. My goal is to make these modelling tools accurate and robust enough to be used in the clinic.