I am a reproductive biologist working to define key mechanisms for sperm development and function; and by extension the causes of human male infertility.
My research activity is focused on the application of metabolomics to understand the role of lysosomes in health and disease. I have a major interest in understanding the molecular mechanisms of pathology resulting from lysosomal dysfunction. The outcomes
I am a biochemical geneticist working on the genetics and pathogenesis of mitochondrial energy generation disorders. I have a particular focus on the severe mitochondrial diseases of childhood but am also studying mitochondrial involvement in common disor
I am an applied respiratory physiologist investigating the pathophysiology of upper airway dysfunction in individuals with sleep-disordered breathing and the application of exercise physiology principles to the development of novel rehabilitation methods
The primary aim of my research has been to understand how biological ion channels work. All electrical activities in the nervous system, including communication between cells and influences of hormones and drugs on cell function, are regulated by the opening and closing of ion channels. Thus, understanding how these ion channels operate will ultimately help us find the causes of, and possibly cures for, many neurological, muscular and cardiac disorders.