A Mechanistic Approach To Therapy Development For Chronic Traumatic Encephalopathy Using Small And Large Animal Models Of Concussion
Funder
National Health and Medical Research Council
Funding Amount
$492,844.00
Summary
Repeated concussion in athletes has recently been associated with the development of a neurodegenerative disorder known as chronic traumatic encephalopathy (CTE). While the neuropathology seems to be well characterised, the mechanisms associated with CTE development are not. This proposal will demonstrate that mechanically induced release of the neurotransmitter substance P accounts for much of the neuropathology in CTE, and will develop a novel therapy that will prevent such development.
“The Aftershock” – Understanding The Impact Of Traumatic Brain Injury On Depression And Emotional Regulation.
Funder
National Health and Medical Research Council
Funding Amount
$678,771.00
Summary
The majority of people with a traumatic brain injury (TBI) experience problems with mood and emotional regulation. We will use imaging to measure brain changes from TBI, and link these to risk of depression, as well as behavioural and molecular alterations. Study cohorts will include former international footballers, junior sports people and emergency patients presenting with an acute TBI. The project will inform current policy and provide a strong scientific basis for future work.
Mild Traumatic Brain Injuries And Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$928,690.00
Summary
Repeated mild traumatic brain injuries (RmTBIs) have been linked to the development of neurodegenerative conditions. However, whether RmTBIs cause neurodegenerative disease, and the factors involved, requires further research. Using an innovative rat model, this project will examine whether RmTBIs cause long-term neurological changes resembling neurodegenerative disease. This cutting-edge project is highly relevant to human patients and will improve our understanding of these common injuries.
Investigating The Consequences, Pathogenesis, And Treatment Of Repeated Brain Concussions In A Novel Rodent Model
Funder
National Health and Medical Research Council
Funding Amount
$513,752.00
Summary
Concussions are now recognized as a serious medical issue. There is particular concern for individuals who are at high risk of suffering concussions, such as soldiers and athletes, as evidence indicates that repeated concussions are associated with neurodegenerative disease. Here we will use an animal model of repeated concussion to examine these injuries. These studies will increase our understanding of concussion, and hold important implications for their management in the clinical setting.