ACTION - Aggression In Children: Unravelling Gene-environment Interplay To Inform Treatment
Funder
National Health and Medical Research Council
Funding Amount
$453,871.00
Summary
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. ACTION will deliver an overarching framework that combines a thorough understanding of pathways leading to aggression with a map of current gaps, best practices on clinical, ethical, legal, and social issues.
Early Intervention For Treatment-resistant Conduct Disorder In Children
Funder
National Health and Medical Research Council
Funding Amount
$694,280.00
Summary
Conduct problems (CP) in childhood are the most reliable precursor of all types of adult mental health problems. Conclusive evidence now exists to show that a subgroup within CP children, those with high levels of callous-unemotional (CU) traits are etiologically distinct and are relatively unresponsive to existing evidence-based treatments.The aim of the current programme is to test a new treatment for these children.
The Natural History Of Disruptive Behaviour Disorders: Symptom Trajectory, Outcomes, And Intervention
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This Fellowship aims to determine why some young people with disruptive behaviour disorders (attention-deficit/hyperactivity disorder and conduct disorder) have worse outcomes than others with the same disorders. This body of work will investigate how differences in symptoms and environmental factors determine their outcomes in later life. These findings will also be used to develop an intervention targeted at young at-risk Australians.
Innovative Models Of Early Intervention For Conduct Disorders In Children
Funder
National Health and Medical Research Council
Funding Amount
$826,854.00
Summary
Most mental health problems begin in childhood, and Oppositional-defiant and conduct problems are the most reliable precursor of adult mental health problems. The lifetime costs on public services for these children are large. Australia has no strategy for managing this problem, and urgently needs to develop evidence-based approaches. This program of research will develop improved methods for identifying, assessing and treating child conduct disorders as part of our national strategy for early i ....Most mental health problems begin in childhood, and Oppositional-defiant and conduct problems are the most reliable precursor of adult mental health problems. The lifetime costs on public services for these children are large. Australia has no strategy for managing this problem, and urgently needs to develop evidence-based approaches. This program of research will develop improved methods for identifying, assessing and treating child conduct disorders as part of our national strategy for early intervention for mental health.Read moreRead less
ADHD And Comorbidity: Implications For Clinical Practice And Molecular Genetics
Funder
National Health and Medical Research Council
Funding Amount
$284,878.00
Summary
ADHD is emerging as the most common, controversial childhood behavioural problem. Previously we have shown that much of the confusion may lie in the fact that ADHD is inherited as a continuum throughout the entire population, only some people having such a strong genetic potential that they warrant the label ADHD. The threshold to achieve this label is partly a community one, leading to the argument over who should be labelled and treated. This grant goes further in examining the possibility tha ....ADHD is emerging as the most common, controversial childhood behavioural problem. Previously we have shown that much of the confusion may lie in the fact that ADHD is inherited as a continuum throughout the entire population, only some people having such a strong genetic potential that they warrant the label ADHD. The threshold to achieve this label is partly a community one, leading to the argument over who should be labelled and treated. This grant goes further in examining the possibility that there is more than one type of ADHD. Some ADHD children have other behavioural problems such as conduct disorder or learning problems. Some have problems throughout their lives while others grow out of it. In Australia we are unique in having developed the most extensive twin databases world-wide and have already studied aspects of ADHD both in the children and their parents. In this grant we shall explore whether there are distinct genetic types of ADHD, characterised not just by their ADHD symptoms but also by the other behavioural problems they experience and by what happens as they grow-up. Such information is invaluable in developing a treatment program dealing with all aspects of the ADHD and also addresses the question of what will happen as they get older. No other study internationally has such extensive data to address these key questions., vital both to clinicians and families. Given the significant genetic component to ADHD, the next possibility is to find the genes involved in the different types. Knowing what these genes do may help in the development of medications more targeted to specific patterns of problems. Recently genes have been identified which may be involved in specific types of ADHD, as well as genes involved in associated problems such as reading disability and substance abuse. This study offers the potential to clearly identify the role of these genes and so assist in improved diagnosis and treatment interventions.Read moreRead less
Preconception Predictors Of Health, Behaviour And Emotional Adjustment At Seven Years
Funder
National Health and Medical Research Council
Funding Amount
$1,170,830.00
Summary
An understanding of the importance of a healthy start to life has underpinned major health policies including Australia’s National Agenda for Early Childhood. The capacity of parents to provide that healthy start has received little study. The present project investigates the extent to which parental lifestyle, social and emotional adjustment prior to conception predictor emotional problems, disruptive behaviour and health in their children at seven years.
ADHD Grown-up: Genetic And Environmental Determinants Of The Adult Outcomes Of Childhood ADHD And Comorbid Conditions
Funder
National Health and Medical Research Council
Funding Amount
$289,542.00
Summary
ADHD remains a controversial issue especially in adulthood. There are many related behavioural problems including substance abuse, anxiety, depression, and personality disorders. Australia is such a focus for twin research that many twin families have taken part in several studies of different aspects of mental health over the years. This grant allows us to link the various datasets to create a unique longitudinal genetic resource and to examine the longterm outcomes.
The Development, Assessment And Treatment Of Early Indicators Of Psychopathy In Children
Funder
National Health and Medical Research Council
Funding Amount
$271,130.00
Summary
2.7 Significance - Lay description Conduct problems and antisocial behaviour cost Australian society millions of dollars every year directly through the mental health and criminal justice systems, indirectly through their association with substance abuse and other mental health problems, and associated disruptions to health, relationships, and personal and occupational functioning. Remediation is not effective once a chronic pattern has been established. Recently, research has shown that early s ....2.7 Significance - Lay description Conduct problems and antisocial behaviour cost Australian society millions of dollars every year directly through the mental health and criminal justice systems, indirectly through their association with substance abuse and other mental health problems, and associated disruptions to health, relationships, and personal and occupational functioning. Remediation is not effective once a chronic pattern has been established. Recently, research has shown that early signs of psychopathy in children predict chronic antisocial behaviour and lack of responsiveness to traditional treatments. The current research uses a combination of experimental, longitudinal, and treatment outcome studies to examine: the effectiveness with which early signs of a callous-unemotional temperamental style, hypothesised to be an early indicator of psychopathy, can be measured in children, causal factors and correlates of callous-unemotional traits, whether such traits pose a risk for chronic antisocial behaviour, the effects of callous-unemotional traits on responsiveness to traditional family-school based treatments, and the effectiveness of an innovative method for treating it in the early years. The project leads directly to a range of clinical assessment and treatment strategies for children at risk for chronic antisocial behaviour. The project has the potential to substantially improve the effectiveness of current treatment approaches to conduct problems in children that focus on family and school management.Read moreRead less
Behavioural And Neuropsychiatric Aspects Of Transition To Severe Conduct Disorder In Adolescence.
Funder
National Health and Medical Research Council
Funding Amount
$343,100.00
Summary
Conduct disorder represents an enormous cost to Australian society directly via the mental health and forensic systems, and indirect costs via its associations with other mental health problems, relationship problems, impaired social functioning, and substance use problems. Behavioural-family-based treatment have good success rates with young children with cooperative parents, however, there are a minority who progress to chronic problems despite this. Risk and resilience factors identifying chr ....Conduct disorder represents an enormous cost to Australian society directly via the mental health and forensic systems, and indirect costs via its associations with other mental health problems, relationship problems, impaired social functioning, and substance use problems. Behavioural-family-based treatment have good success rates with young children with cooperative parents, however, there are a minority who progress to chronic problems despite this. Risk and resilience factors identifying chronic patterns in early childhood are the key to early intervention. In previous research, this research team showed for the first time that callous-unemotional traits, a feature of chronic psychopathy, could be measured in children as young as 4 years, and was predictive of a range of negative outcomes. However, it was also found that the key neuropsychiatric markers characteristic of psychopathy, including reward dominance-punishment insensitivity and deficits in affective empathy, did not exist in conduct problem children prior to adolescence. Around the time of puberty, it appears that important changes occur in cognitive-affective processing styles that are associated with the adult form of psychopathy and antisocial behaviour. Thus, this research raises critical questions about the development of severe antisocial behaviour (or psychopathy) through the childhood to adolescent years. Our evidence indicates that early adolecence may be the period when intrapsychological characteristics representing chronic risk become concrete. The current research will be the first to map the development common neuropsychiatric markers (affective empathy, punishment insensitivity) of severe antisocial processes through the late childhood-adolescent period. The findings will have clear implications for models of antisocial behaviour and clinical approaches to working with conduct problem children and adolescents.Read moreRead less