New approaches for screening cereal germplasm for enhanced microbial pathogen resistance and desirable grain texture. The trait of grain hardness (texture) is of significance to the Australian infrastructure, as exports of hard wheat contribute over 5 billion dollars per year on average to the national economy and hard wheats are also important for domestic usage. The genes responsible for grain texture also impart resistance to bacterial and fungal pathogens which can cause extensive damage. ....New approaches for screening cereal germplasm for enhanced microbial pathogen resistance and desirable grain texture. The trait of grain hardness (texture) is of significance to the Australian infrastructure, as exports of hard wheat contribute over 5 billion dollars per year on average to the national economy and hard wheats are also important for domestic usage. The genes responsible for grain texture also impart resistance to bacterial and fungal pathogens which can cause extensive damage. However, the Australian gene pool has very limited genetic diversity in grain textures and thus possibly in pathogen resistance. The project will work out the science behind these two traits and identify lines with new variants of textures and pathogen resistances, thus greatly benefiting the national infrastructure and local primary industries.Read moreRead less
ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology indust ....ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology industry, the protection of the Australian Environment and the well-being of the Australian people. Key issues for this Centre include testicular cancer, male infertility, contraception, pest animal control, environmental impacts on human health and gene pharming.Read moreRead less
Online anti-racism for Australia. Harmful manifestations of online racism are increasing. The neo-liberal assumption is that social media users and user groups can be responsiblised to disrupt online racism. This project analyses a subset of online anti-racism campaigns. The review provides the material to test effectiveness, using surveys. The survey findings will identify the ingredients for effective, safe and efficient online anti-racism intervention. An online anti-racism program will be de ....Online anti-racism for Australia. Harmful manifestations of online racism are increasing. The neo-liberal assumption is that social media users and user groups can be responsiblised to disrupt online racism. This project analyses a subset of online anti-racism campaigns. The review provides the material to test effectiveness, using surveys. The survey findings will identify the ingredients for effective, safe and efficient online anti-racism intervention. An online anti-racism program will be developed, implemented and evaluated. The development of guidelines for online anti-racism will overtly address the challenges and risks of action in this environment where regulation is so heavily contested.Read moreRead less
Making Human T- And B-lymphocytes For Immunotherapy And Antibody Production
Funder
National Health and Medical Research Council
Funding Amount
$795,880.00
Summary
Lymphocytes are white blood cells that are involved in producing antibodies, killing defective cells, or killing cells infected with viruses. In recent years, researchers have found ways to harness lymphocytes to develop medicines for treating a variety of different cancers. In this project, we will establish methods to make human lymphocytes in the laboratory from stem cells, paving the way for the broader application of this cell type to new therapies.
Control Of Human ? Cell Differentiation And Function
Funder
National Health and Medical Research Council
Funding Amount
$616,979.00
Summary
Diabetes is a condition in which the body is unable to regulate the level of glucose in the blood. Blood glucose is normally controlled by a particular cell type, the beta cell, which is found in the pancreas. In diabetes, this cell is either missing or does not function correctly. This project will produce human beta cells in the laboratory that can be used to find out what goes wrong in diabetes.
Transition to adulthood in greater Jakarta: A longitudinal perspective. Interviewing 3,000 young adult Indonesians at two points in time, this project examines whether their economic and social outcomes change across time or whether early experience determines longer-term outcomes. What are the factors involved in transition to adulthood among young people in a rapidly developing metropolis of a developing country?
Migration, Mixed Marriage and Integration in Australia. This project aims to investigate the prevalence, experience and variations of ethnic and religious mixed marriage in Australia, which will guide policies that facilitate social integration and cohesion. The implications of a lack of integration have been demonstrated by recent events in Europe and US, which reflect strong anti-immigration tendencies. This project expects to generate new sociological knowledge of ethnic/religious mixed-marri ....Migration, Mixed Marriage and Integration in Australia. This project aims to investigate the prevalence, experience and variations of ethnic and religious mixed marriage in Australia, which will guide policies that facilitate social integration and cohesion. The implications of a lack of integration have been demonstrated by recent events in Europe and US, which reflect strong anti-immigration tendencies. This project expects to generate new sociological knowledge of ethnic/religious mixed-marriage, new understanding in social integration and enhanced research capacity in the area of migration and integration. This research should provide significant benefits, such as enhanced cultural understanding and appropriate policies that foster social integration of cultural groups.Read moreRead less
Cellular Mechanisms Controlling Neural Crest Cell Migration Along The Developing Gut
Funder
National Health and Medical Research Council
Funding Amount
$368,895.00
Summary
Within the wall of the gut, there are a large number of neurons, probably more than are in the spinal cord. These enteric neurons play an essential role in controlling a number of gut functions including peristalsis (the propulsion of contents along the gut). Most of the neurons in the gut, including those in the large intestine, arise from precursors that emigrate from the hindbrain, and then migrate into and along the gastrointestinal tract during development. The colonization of the gut by ne ....Within the wall of the gut, there are a large number of neurons, probably more than are in the spinal cord. These enteric neurons play an essential role in controlling a number of gut functions including peristalsis (the propulsion of contents along the gut). Most of the neurons in the gut, including those in the large intestine, arise from precursors that emigrate from the hindbrain, and then migrate into and along the gastrointestinal tract during development. The colonization of the gut by neuron precursors takes 5 days in mice and 6 weeks in humans. Studies of the mechanisms controlling the migration of neuron precursors along the gut have provided fundamental information about cell migration in general. Genetic studies in humans and mice have identified some of the genes that are necessary for the migration of neuron precursors along the gastrointestinal tract, but for some of the key genes, their precise role is unknown. We have recently developed a method for imaging living neuron precursors migrating through explants of embryonic mouse gut. In the current proposal we will meld imaging and genetic studies to understand how mutations in particular genes lead to migration defects. In particular, how do particular mutations affect the migratory behaviour of enteric neural precursors? We have also previously shown that neuron precursors migrate along the gut in close association with axons. We will examine the nature of these interactions - in particular, who is following whom, and what happens when cell migration and axon growth are uncoupled? These studies, which will investigate a number of critical aspects of the migration of neural precursors into and along the developing gut, are central to understanding how the enteric nervous system is established along the gastrointestinal tract.Read moreRead less
Diaspora Humanitarians: How Australia-based migrants help in crises abroad. This project aims to map the extensive humanitarian activities and contributions of Australia-based migrants to crises abroad. Australia is home to large diasporas who are connected to communities in many humanitarian crisis hotspots, including the project's focus areas: Afghanistan, Syria, South Sudan, Myanmar, Indonesia, Nepal, and the Pacific Islands. By generating much-needed knowledge on how and why migrants engage ....Diaspora Humanitarians: How Australia-based migrants help in crises abroad. This project aims to map the extensive humanitarian activities and contributions of Australia-based migrants to crises abroad. Australia is home to large diasporas who are connected to communities in many humanitarian crisis hotspots, including the project's focus areas: Afghanistan, Syria, South Sudan, Myanmar, Indonesia, Nepal, and the Pacific Islands. By generating much-needed knowledge on how and why migrants engage in humanitarian responses, the project expects to support and improve the work of diasporas themselves, the Australian Civil-Military Centre and other humanitarian organisations, who are partners in the project. This will benefit Australia by highlighting our innovative leadership role in humanitarian and migration issues.Read moreRead less
Where migrants go: A study of immigrants' post-arrival moves in Australia . The project aims to establish the geographical and occupational trajectories of different migrant groups after arrival in Australia. Migration within Australia is a key driver of economic, demographic and social change. Recognising the growing diversity of immigrants, including the rapid rise in temporary migration, the project examines post-arrival moves of immigrants by visa type, country of birth and year of arrival. ....Where migrants go: A study of immigrants' post-arrival moves in Australia . The project aims to establish the geographical and occupational trajectories of different migrant groups after arrival in Australia. Migration within Australia is a key driver of economic, demographic and social change. Recognising the growing diversity of immigrants, including the rapid rise in temporary migration, the project examines post-arrival moves of immigrants by visa type, country of birth and year of arrival. It seeks to improve understanding of the incidence, spatial patterns and drivers of migrants’ movement within Australia and the socio-demographic impact on regions and individuals. Such understanding is an essential first step to the formulation of effective immigration and settlement policies and programs.Read moreRead less