Control and learning for enhancing capabilities of quantum sensors. This project aims to develop new theories and algorithms to enhance capabilities in engineering quantum sensors from the perspective of systems and control. The project is significant because it is anticipated to advance key knowledge and provide systematic methods to enable achievement of high-precision sensing for wide applications, e.g., early disease detection, medical research, discovery of ore deposits and groundwater moni ....Control and learning for enhancing capabilities of quantum sensors. This project aims to develop new theories and algorithms to enhance capabilities in engineering quantum sensors from the perspective of systems and control. The project is significant because it is anticipated to advance key knowledge and provide systematic methods to enable achievement of high-precision sensing for wide applications, e.g., early disease detection, medical research, discovery of ore deposits and groundwater monitoring. The intended outcomes are fundamental theories, effective control and learning algorithms for achieving highly-sensitive sensors. These outcomes should make important contributions to and deliver new knowledge and skills for Australia's sensing industries, which could benefit Australia's economic growth.Read moreRead less
Nuclear RNA surveillance and its connection to splicing quality control. Due to the error-prone nature of RNA splicing, elaborate quality control processes ensure that only correctly spliced transcripts can leave the nucleus. It has long been known that incorrectly spliced mRNA transcripts are degraded by the nuclear RNA surveillance machinery, but how the RNA quality control machinery is connected to nuclear RNA surveillance is not known. This proposal aims to uncover the connection between the ....Nuclear RNA surveillance and its connection to splicing quality control. Due to the error-prone nature of RNA splicing, elaborate quality control processes ensure that only correctly spliced transcripts can leave the nucleus. It has long been known that incorrectly spliced mRNA transcripts are degraded by the nuclear RNA surveillance machinery, but how the RNA quality control machinery is connected to nuclear RNA surveillance is not known. This proposal aims to uncover the connection between these two important processes and will fill a significant gap in our understanding of how splicing quality control and nuclear RNA surveillance work. The project will also identify sequence features that trigger abortive splicing reactions and will thus help to improve the design of synthetic mRNAs.Read moreRead less
Role of R-loops and double R-loops in genome organisation and transcription. The majority of our genome is converted to an extensive network of non-protein-coding RNA molecules (ncRNAs), but the function of these ncRNAs is unknown. This project aims to identify and determine the mechanism of action of nuclear ncRNA networks with a particular focus on nuclear ncRNAs that form RNA-DNA hybrids with the genomic DNA. These studies have the potential to lead to ground-breaking discoveries in our under ....Role of R-loops and double R-loops in genome organisation and transcription. The majority of our genome is converted to an extensive network of non-protein-coding RNA molecules (ncRNAs), but the function of these ncRNAs is unknown. This project aims to identify and determine the mechanism of action of nuclear ncRNA networks with a particular focus on nuclear ncRNAs that form RNA-DNA hybrids with the genomic DNA. These studies have the potential to lead to ground-breaking discoveries in our understanding of genome organisation and the mechanism of transcription control, and might provide an entirely new tool-box to manipulate genome function. This should provide significant benefits to efforts to develop innovative biotechnology and genome editing technologies in plants and animals.Read moreRead less
RNA surveillance and the initial steps of RNA biogenesis. This project aims to understand the initial steps of RNA biogenesis and how this process is linked to the chromatin environment. Although less than five per cent of our genome encodes proteins, almost the entire genome is transcribed to RNA. A large portion of these transcripts are degraded during the early steps of RNA biogenesis by the RNA surveillance machinery, but the mechanism for the recognition and degradation of these transcripts ....RNA surveillance and the initial steps of RNA biogenesis. This project aims to understand the initial steps of RNA biogenesis and how this process is linked to the chromatin environment. Although less than five per cent of our genome encodes proteins, almost the entire genome is transcribed to RNA. A large portion of these transcripts are degraded during the early steps of RNA biogenesis by the RNA surveillance machinery, but the mechanism for the recognition and degradation of these transcripts is not understood. New evidence suggests that the chromatin environment of the transcribed locus plays an important role in this process. This project will lead to significant benefits in the implementation of emerging RNA-based technologies and in understanding how genome stability is maintained.Read moreRead less
How and why cells decorate their genetic messages. This project aims to investigate a new layer of genomic control mediated not by DNA but instead by chemical modifications found on the cell's working copies of genetic information called messenger RNA. The investigations will use cutting-edge RNA sequencing technology and the fruit fly model organism to uncover the scope and mechanisms by which such modifications enact their roles at the molecular level and within the body plan of an animal. Exp ....How and why cells decorate their genetic messages. This project aims to investigate a new layer of genomic control mediated not by DNA but instead by chemical modifications found on the cell's working copies of genetic information called messenger RNA. The investigations will use cutting-edge RNA sequencing technology and the fruit fly model organism to uncover the scope and mechanisms by which such modifications enact their roles at the molecular level and within the body plan of an animal. Expected outcomes include novel molecular tools and models that will assist in understanding and manipulating the function of genomes. Such knowledge should provide benefits in developing innovative biotechnology applications of use in human health, agriculture and managing the environment.
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Control of network systems with signed dynamical interconnections. New technologies such as online recommendations, smart grids, and cyber-physical systems are becoming backbone infrastructure. Such systems are operated as network systems with interconnected functioning units (agents) where cooperative and adversarial agent relations often coexist. This project aims to develop the theories and tools for designing and building dynamic networks with signed interactions that arise from a variety of ....Control of network systems with signed dynamical interconnections. New technologies such as online recommendations, smart grids, and cyber-physical systems are becoming backbone infrastructure. Such systems are operated as network systems with interconnected functioning units (agents) where cooperative and adversarial agent relations often coexist. This project aims to develop the theories and tools for designing and building dynamic networks with signed interactions that arise from a variety of applications where both cooperative and adversarial agent interactions coexist. By developing theories and algorithms for control and identification over such systems, this project will contribute directly to their safe and robust operation. The resulting theories will provide deeper understanding of network control systems and the resulting algorithms will enable the elimination of attackers and malicious users for online review systems and smart grids. This project will contribute to increased cybersecurity for all Australians.Read moreRead less
Cooperative control of networked systems with constraints. This project aims to address the challenge of networked systems in deploying teams of robotic agents. Control of the networked system is extremely difficult due to real world constraints imposed on each agent. This project will focus on motion constraints, equipment/capability constraints, and spatial constraints. In addition to theoretical advances, the wider scientific community will benefit directly, because the control algorithms dev ....Cooperative control of networked systems with constraints. This project aims to address the challenge of networked systems in deploying teams of robotic agents. Control of the networked system is extremely difficult due to real world constraints imposed on each agent. This project will focus on motion constraints, equipment/capability constraints, and spatial constraints. In addition to theoretical advances, the wider scientific community will benefit directly, because the control algorithms developed are expected to allow straightforward deployment of robotic teams. There are myriad applications for cooperative robotic agents, ranging from surveillance, to environmental monitoring using underwater and aerial drone formations – with an array of benefits and impacts including economic, commercial and societal. The results are intended to ensure and cement Australia’s front-line position in the current technological revolution known as “Industry 4.0”.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100003
Funder
Australian Research Council
Funding Amount
$4,930,205.00
Summary
ARC Training Centre for Biofilm Research and Innovation . The ARC Training Centre for Biofilm Research and Innovation aims to transform biofouling management strategies for maritime platforms by building on local and international expertise to mentor and train the next generation of interdisciplinary scientists and engineers. Anticipating evolving regulatory stringency, this project expects to establish a dynamic environment for industry partners, students and scientists to collaborate and devel ....ARC Training Centre for Biofilm Research and Innovation . The ARC Training Centre for Biofilm Research and Innovation aims to transform biofouling management strategies for maritime platforms by building on local and international expertise to mentor and train the next generation of interdisciplinary scientists and engineers. Anticipating evolving regulatory stringency, this project expects to establish a dynamic environment for industry partners, students and scientists to collaborate and develop biofilm management strategies. Expected outcomes include new and enhanced collaborations that advance and translate knowledge to better manage biofouling. The significant benefits will include a generation of industry-focused researchers critical for growing Australia’s Defence industry.Read moreRead less
Fast Precision Robust Control of Resonant Flexible Systems. The project aims to produce new control system design tools to enable fast precision control of advanced engineering systems encorporating flexible structures. This should enable improved speed and accuracy in control systems for precision instruments such as atomic force microscopes along with improving control system performance in areas of precision engineering such as semiconductor manufacturing, robotics and microelectromechanical ....Fast Precision Robust Control of Resonant Flexible Systems. The project aims to produce new control system design tools to enable fast precision control of advanced engineering systems encorporating flexible structures. This should enable improved speed and accuracy in control systems for precision instruments such as atomic force microscopes along with improving control system performance in areas of precision engineering such as semiconductor manufacturing, robotics and microelectromechanical systems. The outcomes are expected to be new control system synthesis and modelling tools enabling fast and highly accurate control of industrial systems using nonlinear and switching elements and achieving high levels of robustness. This will benefit Australian precision manufacturing industries.Read moreRead less