The Role Of Central Haemodynamics In Type 2 Diabetes Mellitus-related Brain Disease
Funder
National Health and Medical Research Council
Funding Amount
$899,704.00
Summary
Type 2 Diabetes Mellitus is associated with stiffening of major blood vessels which may allow the transmission of harmful pressure to the small vessels of the brain. This may in turn be responsible for damage to brain cells and a greater risk of dementia. This study will use state-of-the art techniques to test this theory. If true, it may open opportunities to reduce the risk of brain disease in diabetes by using therapies to reduce arterial stiffening.
Developing a wildlife health intelligence and vaccine distribution system. This project aims to establish an industry-linked pipeline for vaccines to be delivered to animals in edible baits and a near real-time monitoring system for assessing the impact of management actions. This project will develop ultrasensitive diagnostic tests and incorporate biomarkers into baits from Australia's leading pest animal control company. Bait uptake and disease status in the field will be monitored using artif ....Developing a wildlife health intelligence and vaccine distribution system. This project aims to establish an industry-linked pipeline for vaccines to be delivered to animals in edible baits and a near real-time monitoring system for assessing the impact of management actions. This project will develop ultrasensitive diagnostic tests and incorporate biomarkers into baits from Australia's leading pest animal control company. Bait uptake and disease status in the field will be monitored using artificial intelligence technology developed in Tasmania. This integrated wildlife health intelligence and scalable vaccine platform can help protect the iconic Tasmanian devil from disease and increase Australia's preparedness for looming threats to the livestock industry such as African swine fever.Read moreRead less
Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perfo ....Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perform rapid on-site mapping of nutrients and other water quality parameters in large water bodies, intensive scale mapping of effluent mixing and dispersal zones, quick assessment of the impact of dredging and aquaculture, and compliance monitoring in effluent streams.
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Industrial Transformation Training Centres - Grant ID: IC220100003
Funder
Australian Research Council
Funding Amount
$4,930,205.00
Summary
ARC Training Centre for Biofilm Research and Innovation . The ARC Training Centre for Biofilm Research and Innovation aims to transform biofouling management strategies for maritime platforms by building on local and international expertise to mentor and train the next generation of interdisciplinary scientists and engineers. Anticipating evolving regulatory stringency, this project expects to establish a dynamic environment for industry partners, students and scientists to collaborate and devel ....ARC Training Centre for Biofilm Research and Innovation . The ARC Training Centre for Biofilm Research and Innovation aims to transform biofouling management strategies for maritime platforms by building on local and international expertise to mentor and train the next generation of interdisciplinary scientists and engineers. Anticipating evolving regulatory stringency, this project expects to establish a dynamic environment for industry partners, students and scientists to collaborate and develop biofilm management strategies. Expected outcomes include new and enhanced collaborations that advance and translate knowledge to better manage biofouling. The significant benefits will include a generation of industry-focused researchers critical for growing Australia’s Defence industry.Read moreRead less
Protecting Australia’s food future: shared responsibility for biosecurity. This project aims to investigate whether Australia’s ‘shared responsibility’ approach to biosecurity is capable of facing the growing threat from exotic pests and diseases. Through the analysis of policy documents and the use of semi-structured interviews, this project intends to contribute to a deeper understanding of the inter- and intra-organisational characteristics that influence implementation of biosecurity. Expect ....Protecting Australia’s food future: shared responsibility for biosecurity. This project aims to investigate whether Australia’s ‘shared responsibility’ approach to biosecurity is capable of facing the growing threat from exotic pests and diseases. Through the analysis of policy documents and the use of semi-structured interviews, this project intends to contribute to a deeper understanding of the inter- and intra-organisational characteristics that influence implementation of biosecurity. Expected outcomes include crucial insights into the capacity of a shared responsibility approach to protect agri-food production against biological threats, and the forms of institutional change that may be needed to enhance responsiveness to those threats. This in turn will benefit Australia's biosecurity system.Read moreRead less
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Disease in endangered species: The importance of multiple-host infection and spatial structure. Pathogens are increasingly recognised as threats to endangered species. Managing such threats requires models to assess alternative strategies. Most current models deal with a single host and single pathogen, without spatial structure, although multiple-host pathogens pose the greatest conservation threats. This project develops a new generation of spatially-structured multiple-host models, and applie ....Disease in endangered species: The importance of multiple-host infection and spatial structure. Pathogens are increasingly recognised as threats to endangered species. Managing such threats requires models to assess alternative strategies. Most current models deal with a single host and single pathogen, without spatial structure, although multiple-host pathogens pose the greatest conservation threats. This project develops a new generation of spatially-structured multiple-host models, and applies them to two case studies. The first is the chytrid fungus that is thought to have lead to widespread declines and extinctions of frogs in Australia and overseas. The second is birdpox and malaria that have led to the extinction and endangerment of much of Hawaii's endemic avifauna.Read moreRead less
3D printed microchemical devices and systems. This project aims to address the barriers faced by 3D printing in chemistry. 3D printing can create bespoke 3D structures within a fraction of time and cost compared to traditional fabrication. However, its scope in chemistry has been limited by the poor chemical robustness, biotoxicity and low resolution of the 3D printed components. Hence, this project will develop novel gold coating techniques and explore high-resolution 3D printing to overcome th ....3D printed microchemical devices and systems. This project aims to address the barriers faced by 3D printing in chemistry. 3D printing can create bespoke 3D structures within a fraction of time and cost compared to traditional fabrication. However, its scope in chemistry has been limited by the poor chemical robustness, biotoxicity and low resolution of the 3D printed components. Hence, this project will develop novel gold coating techniques and explore high-resolution 3D printing to overcome these challenges. The project should generate commercially significant products (analytical platforms), technology (gold coating) and patents. The developed systems and technologies will address Australian research challenges in advanced manufacturing and enable on-site environmental monitoring.Read moreRead less
An autonomous microfluidic analyser for the determination of total phosphorus and nitrogen in aquatic systems. Development of automated monitoring systems capable of extended and remote operation will enable assessment of the effectiveness of water treatment and the impact of nutrient releases on the aquatic environment. Both are important in preserving the quality of existing water resources, and assessing the quality of recycled water, in line with the National Research Priority Environmentall ....An autonomous microfluidic analyser for the determination of total phosphorus and nitrogen in aquatic systems. Development of automated monitoring systems capable of extended and remote operation will enable assessment of the effectiveness of water treatment and the impact of nutrient releases on the aquatic environment. Both are important in preserving the quality of existing water resources, and assessing the quality of recycled water, in line with the National Research Priority Environmentally sustainable Australia, and the Priority Goal, Water - a critical resource. Commercialization of the microfluidic flow analysis system for total N and P will enhance the international competitiveness of Ecotech Pty Ltd and Australia as an exporter of scientific instruments.Read moreRead less
Integrated biological control of Sclerotinia minor root rot of pyrethrum crops. Tasmania is a major global supplier of natural pyrethrum, producing 25% of the world's requirements. However the industry has a major problem with Sclerotinia minor, current chemical treatment being expensive and providing limited effectiveness. The aim of this project is to develop long term integrated control measures for this disease, particularly by the application of biological control agents targeting S. minor ....Integrated biological control of Sclerotinia minor root rot of pyrethrum crops. Tasmania is a major global supplier of natural pyrethrum, producing 25% of the world's requirements. However the industry has a major problem with Sclerotinia minor, current chemical treatment being expensive and providing limited effectiveness. The aim of this project is to develop long term integrated control measures for this disease, particularly by the application of biological control agents targeting S. minor at planting. It will also examine possible break-crops biocidal to the fungus, and other integrated control measures. The significance/outcomes will be improved crop productivity to the industry, improved competitiveness with overseas producers and reduced dependence on chemical pesticides.Read moreRead less