Enhancing Direct Cu Recovery through Increased Gas Processing Understanding. This project aims to investigate mechanisms of copper loss during smelting and find new ways to reduce the loss. Smelting, which produces copper matte product and slag tailings, is an important step of the copper-making process from copper sulphides. The loss of copper to slag can be as high as 12 per cent. The project aims to create new knowledge about copper loss by matte droplets floated with gas bubbles generated by ....Enhancing Direct Cu Recovery through Increased Gas Processing Understanding. This project aims to investigate mechanisms of copper loss during smelting and find new ways to reduce the loss. Smelting, which produces copper matte product and slag tailings, is an important step of the copper-making process from copper sulphides. The loss of copper to slag can be as high as 12 per cent. The project aims to create new knowledge about copper loss by matte droplets floated with gas bubbles generated by chemical reactions to the slag phase. The outcomes are intended to enable copper smelters to maximise direct copper recovery, reduce copper production costs and increase the productivity of the smelting process.Read moreRead less
Mechanisms Of Proteolysis Of Proteins Containing Oxidised Amino Acids
Funder
National Health and Medical Research Council
Funding Amount
$406,320.00
Summary
There is evidence that during ageing, and age-related diseases, proteins which have been chemically modified by oxidation accumulate in the body, and may have deleterious effects. Oxidation of proteins is a process akin to that by which fats go rancid. It has been demonstrated by the applicants to be an important process in formation of cataracts, and in development of the blood vessel disease, atherosclerosis, which is responsible for most heart attacks and stroke. Other important age-related d ....There is evidence that during ageing, and age-related diseases, proteins which have been chemically modified by oxidation accumulate in the body, and may have deleterious effects. Oxidation of proteins is a process akin to that by which fats go rancid. It has been demonstrated by the applicants to be an important process in formation of cataracts, and in development of the blood vessel disease, atherosclerosis, which is responsible for most heart attacks and stroke. Other important age-related diseases, such as Alzheimer s disease and other neurological disorders, are also claimed to be associated with deranged protein oxidation, and accumulation of oxidised products. There is clear evidence that certain defensive mechanisms, such as those acting to remove invading organisms and clear wounds, are also associated with an enhanced production of oxidised proteins. Perhaps the most important component of defense against oxidised proteins is their removal by complete breakdown to constituent components, and excretion. Normally, the machinery for breakdown of proteins is in vast excess over the required rate of degradation. However, clearly in these conditions of accumulation of oxidised proteins, this is no longer the case, or no longer suffices. Mechanisms by which oxidised proteins are degraded are poorly understood, and quite controversial. Therefore, the present studies bring to bear a new approach to studying this issue, which has been developed by the applicants. The aim is to reveal mechanisms involved in the breakdown of proteins containing oxidised amino acids, both in cellular systems, and in vivo. Such an understanding may allow us to envisage how to remove oxidised proteins by therapeutic means and therefore interfere with the development of age-related diseases such as Alzheimer s disease and cataract formation and the diseases of the blood vessels associated with attack and stroke.Read moreRead less
Mechanisms Of Oxidised Protein Accumulation In Ageing Cells
Funder
National Health and Medical Research Council
Funding Amount
$429,000.00
Summary
Australia has one of the world's most rapidly ageing populations. It is estimated that in 30 years time over 30% of the population will be over 65; many will suffer from a debilitating, age-related disease. The diseases of ageing represent one of the major health challenges this century. Despite their increasing incidence, our understanding of the underlying causes is limited. A common feature is the accumulation of damaged proteins in cells and tissues. Damaged proteins are usually broken down ....Australia has one of the world's most rapidly ageing populations. It is estimated that in 30 years time over 30% of the population will be over 65; many will suffer from a debilitating, age-related disease. The diseases of ageing represent one of the major health challenges this century. Despite their increasing incidence, our understanding of the underlying causes is limited. A common feature is the accumulation of damaged proteins in cells and tissues. Damaged proteins are usually broken down by the cells and replaced, but in many age-related diseases this process fails. The most common source of protein damage is attack by oxygen-derived free radicals. These are by-products of our body's need for oxygen and can originate from atmospheric pollutants. Oxygen rusts metal, makes fat go rancid and can cause irreparable damage to proteins and other biological molecules. Free radical damage contributes to the development of many age-related diseases such as atherosclerosis and neurodegenerative diseases such as Alzheimer's disease. The accumulation of damaged proteins can cause cell death. Our knowledge of the mechanisms by which cells remove proteins damaged by oxygen and the reasons for their accumulation is limited. In this project we will use a novel technique we have developed to generate oxidised proteins in ageing cells. We will identify cellular mechanisms required for the efficient removal of damaged proteins and those mechanisms which fail in ageing cells. We will focus on a group of proteins which protect damaged proteins from aggregating and accumulating and we will examine how we can prevent the accumulation of oxidised proteins by stimulating the body s defence mechanisms. Since the population of Australia is ageing, diseases of ageing are going to consume an increasing amount of the national health budget. A better knowledge of these cellular mechanisms will allow us to design effective prevention and treatment strategies which are at present lacking.Read moreRead less
A revolution in Earth History: Life and Environment in the Neoarchaean (2.5-2.8 Ga). This research will keep Australian scientists in the forefront of studies of early life on Earth. At a time when there is a great deal of interest in this topic because of the search for similar life elsewhere in the Solar System, this work will take a prominant place in international research. It will attract leading researchers from elsewhere, with consequent intellectual benefits, and will inspire students t ....A revolution in Earth History: Life and Environment in the Neoarchaean (2.5-2.8 Ga). This research will keep Australian scientists in the forefront of studies of early life on Earth. At a time when there is a great deal of interest in this topic because of the search for similar life elsewhere in the Solar System, this work will take a prominant place in international research. It will attract leading researchers from elsewhere, with consequent intellectual benefits, and will inspire students to careers in science.Read moreRead less
Where to find giant porphyry and epithermal gold and copper deposits. This project will determine when and where giant gold or copper deposits should form, consolidating links with Indonesia, and using South East Asia as a vast natural laboratory in which to examine the effect of large-scale tectonic processes. The project will produce a four-dimensional virtual exploration toolkit to show how to apply the methods.
Carbothermal synthesis of titanium carbide. The project's ultimate aim is to develop a comprehensive understanding of carbothermal reduction of titania and ilmenite for titanium carbide production. The projects findings will be of importance to improving the efficiency of carbothermal reduction processes, which are major technologies in ferrous metallurgy, and to the development of titanium industry in Australia.
Australia is the world largest producer of rutile and ilmenite, which are mainly s ....Carbothermal synthesis of titanium carbide. The project's ultimate aim is to develop a comprehensive understanding of carbothermal reduction of titania and ilmenite for titanium carbide production. The projects findings will be of importance to improving the efficiency of carbothermal reduction processes, which are major technologies in ferrous metallurgy, and to the development of titanium industry in Australia.
Australia is the world largest producer of rutile and ilmenite, which are mainly sold overseas and partly processed to titania pigment. Development of the cost-efficient technology for titanium carbide will stimulate a domestic production of this advanced material, what will add enormously to the value of titanium minerals.Read moreRead less
Utilisation of manganese sludge in production of manganese alloys. Australia possesses one of the world's best deposits of manganese ore, and has the potential to increase production of manganese alloys. This depends strongly on the competitiveness of Australian manganese industry. Deposition of manganese sludge, which is formed in ferroalloy furnaces, in fume dams in Bell Bay is costly, occupies valuable land, and causes an environmental concern. Utilisation of manganese sludge back into ferroa ....Utilisation of manganese sludge in production of manganese alloys. Australia possesses one of the world's best deposits of manganese ore, and has the potential to increase production of manganese alloys. This depends strongly on the competitiveness of Australian manganese industry. Deposition of manganese sludge, which is formed in ferroalloy furnaces, in fume dams in Bell Bay is costly, occupies valuable land, and causes an environmental concern. Utilisation of manganese sludge back into ferroalloy furnace will make operation of Tasmanian Electro Metallurgical Company more efficient, sustainable and will stimulate further development of manganese industry in Australia. Read moreRead less
A study of wettability and reduction behaviour in carbothermal production of manganese alloys. The project's ultimate aim is to develop a comprehensive understanding of reactions between carbonaceous materials and molten slag relevant to carbothermal reduction of manganese ore. It will be achieved through experimental study of dynamic wettability and interfacial properties of the carbon - slag system for variety of carbonaceous materials and slag compositions. Reduction behaviour of different ma ....A study of wettability and reduction behaviour in carbothermal production of manganese alloys. The project's ultimate aim is to develop a comprehensive understanding of reactions between carbonaceous materials and molten slag relevant to carbothermal reduction of manganese ore. It will be achieved through experimental study of dynamic wettability and interfacial properties of the carbon - slag system for variety of carbonaceous materials and slag compositions. Reduction behaviour of different manganese ores will also be examined in conjunction with the wettability study. The projects findings will be of importance to carbothermal reduction processes, which are major technologies in ferrous metallurgy, and to further development of the manganese alloys industry in Australia.Read moreRead less
Role Of Transition Metal Ions And Redox Activity In The Development Of Atherosclerotic Plaques
Funder
National Health and Medical Research Council
Funding Amount
$196,018.00
Summary
Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability ....Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability to generate free radicals is controversial. This study will employ a novel, minimally-invasive, technique to assess the nature and quantity of metal ions present in well-defined human and animal lesions at different stages of lesion development. The ability of these metal ions to catalyse free radical formation from components present in the artery wall will also be assessed. The release of these metal ions from the artery wall to added organic molecules will be assessed as this might minimise their potential to cause damage, and provide a possible therapeutic strategy. These studies will therefore provide valuable information as to the significance and role of reactive metal ions in the development of human artery disease and the possible prevention, or minimisation, of such processes.Read moreRead less
Characterisation of carbonaceous materials in production of manganese alloys. Optimisation of the carbonaceous materials feedstock in production of manganese alloys will increase energy efficiency and decrease environmental impact in operation of submerged electric arc furnace. Currently, Australia processes domestically only about 25% of produced manganese ore, while 75% is sold as raw material. Increase in production of manganese alloys will add value to the products and create additional empl ....Characterisation of carbonaceous materials in production of manganese alloys. Optimisation of the carbonaceous materials feedstock in production of manganese alloys will increase energy efficiency and decrease environmental impact in operation of submerged electric arc furnace. Currently, Australia processes domestically only about 25% of produced manganese ore, while 75% is sold as raw material. Increase in production of manganese alloys will add value to the products and create additional employment opportunities, what will be beneficial to the Australian economy. The project will also contribute to further understanding of behaviour of coals in pyrometallurgical processes what will be beneficial to coal industry.Read moreRead less