In Vivo Evaluation Of Coronary Atheroma Burden And Its Association With Focal Coronary Endothelial Function
Funder
National Health and Medical Research Council
Funding Amount
$123,736.00
Summary
Heart attacks remain the leading cause of death in the western world. It has been recently identified that the burden of plaque buildup in the coronary arteries is a major predictor of future heart attacks. Furthermore, it also known that impaired relaxation within the coronary arteries also increases the future risk of heart attacks. The dynamic relationship between these two critical factors remains unknown and an understanding of this is important for predicting future heart attacks.
Investigation Of Insulin Resistance In Cardiac Surgical Patients - Abnormalities In Nitric Oxide Metabolism Are Associated With Insulin Resistance, And May Contribute To Clinical Cardiovascular Disease In Insulin Resistant Patients
Funder
National Health and Medical Research Council
Funding Amount
$74,439.00
Summary
Insulin resistance and diabetes are strongly associated with developing heart disease. Changes in the metabolism of a substance in blood vessels called nitric oxide are seen in diabetes, and are related to heart disease. I will study the relationship between the levels of insulin resistance and markers of nitric oxide metabolism in human subjects, and investigate how this relates to their clinical outcomes after cardiac surgery.
Utility Of Adenosine Stress Cardiac Magnetic Resonance Imaging Following ST Elevation Myocardial Infarction Post Primary Angioplasty
Funder
National Health and Medical Research Council
Funding Amount
$113,322.00
Summary
Heart attacks remain the leading cause of death in the western world. Many patients presenting with an acute heart attack have more than one significant narrowing in the blood vessel. After treatment of the culprit vessel, a robust non invasive imaging technique such as cardiac MRI allows us to study of the extent of damage from the heart attack. In addition, it also enables us to determine the functional significance of the non culprit vessel. This will help guide the management of these patien ....Heart attacks remain the leading cause of death in the western world. Many patients presenting with an acute heart attack have more than one significant narrowing in the blood vessel. After treatment of the culprit vessel, a robust non invasive imaging technique such as cardiac MRI allows us to study of the extent of damage from the heart attack. In addition, it also enables us to determine the functional significance of the non culprit vessel. This will help guide the management of these patients.Read moreRead less
Coronary Atherosclerosis And Its Relationship With Platelet Activation
Funder
National Health and Medical Research Council
Funding Amount
$101,039.00
Summary
Blood clots are critical to the development of heart attacks, which kill many thousands of Australians annually. Platelets are cells in the blood that play an essential role in formation of blood clots, and coronary disease is associated with platelet activation. This research study will investigate the nature of platelet activation in the arteries of the human heart, its relationship to activation of inflammatory cells, and to the severity of narrowings in the arteries of the human heart.