Defining The Role Of IGF-1 As A Novel Angiocrine Factor In The Development And Treament Of Common Craniofacial Disorders
Funder
National Health and Medical Research Council
Funding Amount
$573,848.00
Summary
1 in 1000 children are born with a small jaw, which requires invasive surgery for treatment. We identified that defects in blood vessel development in the jaw underlie some cases of these craniofacial defects. We found that factors secreted from the major artery in the jaw can promote jaw growth, and our research proposal aims to identify what exactly these factors are. These factors have the potential to be used to therapeutically treat children with a small jaw to help it grow correctly.
Identifying The Critical Pathways Which Regulate Vertebrate Craniofacial Development
Funder
National Health and Medical Research Council
Funding Amount
$552,131.00
Summary
Understanding the genes which underlie human birth defects is of immense clinical importance. Our laboratory is a world-leader investigating a gene responsible for facial skeleton development, Grhl2. With our wide range of models, we will discover how Grhl2 works to ensure the face and skull develop properly during birth.
Precise global time scale for the oxidation of Earth's atmosphere between 2.6 and 2.0 billion years ago. The rock record from 2600 to 2000 million years ago preserves evidence for dramatically fluctuating greenhouse and icehouse climates at the same time as, and possibly caused by, change from an oxygen-deficient to an oxygen-rich atmosphere. Although the global changes are well-documented, correlation of their timing and duration between continents is poorly constrained. This project aims to re ....Precise global time scale for the oxidation of Earth's atmosphere between 2.6 and 2.0 billion years ago. The rock record from 2600 to 2000 million years ago preserves evidence for dramatically fluctuating greenhouse and icehouse climates at the same time as, and possibly caused by, change from an oxygen-deficient to an oxygen-rich atmosphere. Although the global changes are well-documented, correlation of their timing and duration between continents is poorly constrained. This project aims to redress that problem by producing a precise calibration of the global changes by analysis of the rock records in Australia, Canada and South Africa. It will provide a much needed time framework within which long-term feedback between atmospheric composition and climate can be understood.Read moreRead less
Murray Basin: A unique archive of late Neogene global change. Salinization, soil erosion, groundwater depletion and surface water degradation are but a few of the inter-related environmental problems facing the Murray-Darling Basin. These problems require an understanding of the way in which shallow groundwater, salts and surface water interact with near-surface sediments. This project is aimed at a better understanding the nature of those near-surface sediments in the Murray Basin and how th ....Murray Basin: A unique archive of late Neogene global change. Salinization, soil erosion, groundwater depletion and surface water degradation are but a few of the inter-related environmental problems facing the Murray-Darling Basin. These problems require an understanding of the way in which shallow groundwater, salts and surface water interact with near-surface sediments. This project is aimed at a better understanding the nature of those near-surface sediments in the Murray Basin and how they were formed. If we can understand how the basin came to be the way it is (in the modern setting), we may better understand the way it might behave when subject to man-made changes like increased groundwater usage, etc.Read moreRead less
A Comprehensive Analysis Of The Role Of The Alcohol Dehydrogenase Gene Cluster In Alcohol-related Disorders And Esophageal Cancer Through Deep Resequencing
Funder
National Health and Medical Research Council
Funding Amount
$605,323.00
Summary
Excessive alcohol consumption remains a major public health concern in Australia where the burden of mental health disorders is dominated by substance-use disorders. Alcohol dehydrogenases (ADHs) are essential in the breakdown of alcohol in the body and we seek to resequence seven ADH genes with the aim to comprehensively catalogue and identify sequence variants that contribute to risk for consuming excessive quantities of alcohol, alcoholism and esophageal squamous cell carcinoma.
Identifying Glaucoma Risk Variants In The Norfolk Island Genetic Isolate
Funder
National Health and Medical Research Council
Funding Amount
$658,447.00
Summary
Primary open angle glaucoma is the most common form of glaucoma. In this project we will focus on the identification of functional genetic variants influencing development of this disorder, using a powerful whole exome sequencing approach in a large multigenerational pedigree from the Norfolk Island population isolate. The identification of genes influencing glaucoma development would provide invaluable clues to aid in defining the pathophysiology of this common disease.
PAST EAST ANTARCTIC ICE SHEET AND GLOBAL SEA-LEVEL VARIATIONS. Unique fossil-bearing, open marine sediments occur inland from the modern Antarctic coastline. These were deposited when a now-glaciated Antarctic basin became a marine embayment, during intervals of significantly reduced ice sheet volume and elevated global sea-level in the past. Urgent palaeontological, sedimentological and geochemical research on these sediments are vital to provide: directly datable in situ evidence for major i ....PAST EAST ANTARCTIC ICE SHEET AND GLOBAL SEA-LEVEL VARIATIONS. Unique fossil-bearing, open marine sediments occur inland from the modern Antarctic coastline. These were deposited when a now-glaciated Antarctic basin became a marine embayment, during intervals of significantly reduced ice sheet volume and elevated global sea-level in the past. Urgent palaeontological, sedimentological and geochemical research on these sediments are vital to provide: directly datable in situ evidence for major ice sheet retreat and global sea-level rise in the past; and quantifiable data concerning the environment during such events; an innovative opportunity to improve predictions of Antarctica's response to global warming and answer international debate about past Antarctic Ice Sheet stability.Read moreRead less
Latest Jurassic history of the Exmouth Sub-basin, North West Shelf: lowstand deposits of the basal Barrow Group. Sand-filled canyons may be excellent petroleum reservoirs, however, interpretation of formation and sediment filling of these major deep marine features is controversial. This project seeks to elucidate the origin of canyons and associated basin floor fans by combining sedimentological data with seismic interpretation and modelling to generate new insights into the history of the E ....Latest Jurassic history of the Exmouth Sub-basin, North West Shelf: lowstand deposits of the basal Barrow Group. Sand-filled canyons may be excellent petroleum reservoirs, however, interpretation of formation and sediment filling of these major deep marine features is controversial. This project seeks to elucidate the origin of canyons and associated basin floor fans by combining sedimentological data with seismic interpretation and modelling to generate new insights into the history of the Exmouth Sub-basin during the Latest Jurassic. In particular, this project provides an opportunity to explore the role of tectonism in canyon formation, the results of which will be of international interest. Geological models developed in this project will enhance our understanding of deep marine systems.Read moreRead less
Southern gateways - the icehouse cometh: Eocene to Oligocene evolution of southeast Australia. The 50 to 30 million years old strata of southeastern Australia have great economic importance for Australia. Most of the gas and oil extracted in the region comes from strata of this age. The research will lead to better age constraints on these reserves, thus enhancing petroleum prospectivity in the area. The global environment changes from 50 to 30 million years charted in this project will lead ....Southern gateways - the icehouse cometh: Eocene to Oligocene evolution of southeast Australia. The 50 to 30 million years old strata of southeastern Australia have great economic importance for Australia. Most of the gas and oil extracted in the region comes from strata of this age. The research will lead to better age constraints on these reserves, thus enhancing petroleum prospectivity in the area. The global environment changes from 50 to 30 million years charted in this project will lead to a better understanding of the geological record of greenhouse-icehouse change. Knowledge of the nature of this change in the past is critical to predicting how our climate is going to behave in the future.Read moreRead less
Seismic velocity problems associated with Cretaceous-Tertiary carbonate sediments that overlie oil and gas fields of the North West Shelf. The major aim of this collaborative study between Partner Oil Companies and The University of Melbourne is to understand seismic velocity problems associated with tropical carbonate sediments on Australias? North West Shelf. These problems can hinder the hydrocarbon exploration efforts below these carbonates. The project is a multi faceted study and will invo ....Seismic velocity problems associated with Cretaceous-Tertiary carbonate sediments that overlie oil and gas fields of the North West Shelf. The major aim of this collaborative study between Partner Oil Companies and The University of Melbourne is to understand seismic velocity problems associated with tropical carbonate sediments on Australias? North West Shelf. These problems can hinder the hydrocarbon exploration efforts below these carbonates. The project is a multi faceted study and will involve integration of seismic stratigraphy with sedimentological, micropaleontological, and geophysical data. The methods outlined below would underpin any seismic depth migration applications, thereby assisting with the delineation of new gas and oil fields, and help with the estimation of reserves in existing fields.
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