It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
RNAi Therapeutic Intervention Of Human Viral Respiratory Disease
Funder
National Health and Medical Research Council
Funding Amount
$584,117.00
Summary
Human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. HMPV is emerging as a major cause of morbidity and life-threatening respiratory tract disease in infants, young children and the elderly worldwide. No treatment is currently available. The objectives of this proposal are to develop novel antiviral drugs that silence the expression of viral genes and to examine protection against the disease.
A Transmission-Blocking Vaccine To Prevent Toxoplasmosis
Funder
National Health and Medical Research Council
Funding Amount
$850,225.00
Summary
Toxoplasma gondii causes a globally important zoonotic disease. It is transmitted by cats, and finds its way into our food chain via infected meat and contaminated water. We have used a unique functional genomics pipeline to discover proteins crucial for reproduction of Toxoplasma in the cat. We will now test combinations of these proteins to immunise cats and prove that we can develop a vaccine that blocks transmission of this highly significant parasitic disease.
Integrating community and family aged care for diverse Australians . This project aims to identify optimal ways to integrate community and family care to support older Australians from diverse cultural backgrounds to age well at home and in their communities. Using an innovative research design, the project seeks to generate new policy and practice relevant knowledge of care networks and expectations of diverse older Australians, their families and service providers to identify new avenues for e ....Integrating community and family aged care for diverse Australians . This project aims to identify optimal ways to integrate community and family care to support older Australians from diverse cultural backgrounds to age well at home and in their communities. Using an innovative research design, the project seeks to generate new policy and practice relevant knowledge of care networks and expectations of diverse older Australians, their families and service providers to identify new avenues for enabling family and community collaboration to meet care needs. Expected outcomes include enhancing Australia’s capacity to provide accessible, tailored and culturally responsive aged care, with significant benefits for improving care experiences for diverse older Australians, their families and service providers.Read moreRead less
Mechanism/s Of Disease Caused By Respiratory Viral Infections
Funder
National Health and Medical Research Council
Funding Amount
$479,517.00
Summary
A newly discovered respiratory virus, human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. Human RSV is a major cause of morbidity and life-threatening respiratory tract disease in infants and young children worldwide, and is recognised as an important respiratory pathogen in elderly adults and immune compromised patients. The recent isolation of HMPV from children hospitalised with respiratory tract ill ....A newly discovered respiratory virus, human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. Human RSV is a major cause of morbidity and life-threatening respiratory tract disease in infants and young children worldwide, and is recognised as an important respiratory pathogen in elderly adults and immune compromised patients. The recent isolation of HMPV from children hospitalised with respiratory tract illness similar to RSV, but with an unknown etiology, suggests that HMPV may mediate similar clinical pathology. Nothing is currently known about the immune response to HMPV, or the association of these responses with lung disease. The objectives of this proposal are to elucidate the mechanisms of immunity and disease pathogenesis associated with human metapneumovirus (HMPV) and to investigate the use of a novel vaccine to protect against HMPV infection. Once this data is obtained, the study will provide the foundation for further research in the development of vaccines or therapeutic protocols to treat HMPV. It will also provide valuable information for understanding the disease in humans. Also,it is likely that HMPV, like hRSV, may prove to be an agent associated with long-term decreased pulmonary function and airflow limitation perhaps developing to asthma.Read moreRead less
Standing up to racism and racial bullying among Australian school students. This project aims to substantially increase understandings of bystander responses (including their extent, nature, potential, merits, benefits, and constraints) as a means of countering racism and racial bullying among Australian school students. This aims to be achieved through examining experiences of, attitudes towards, and responses to, racism and racial bullying among school students; identifying health, wellbeing, ....Standing up to racism and racial bullying among Australian school students. This project aims to substantially increase understandings of bystander responses (including their extent, nature, potential, merits, benefits, and constraints) as a means of countering racism and racial bullying among Australian school students. This aims to be achieved through examining experiences of, attitudes towards, and responses to, racism and racial bullying among school students; identifying health, wellbeing, education and social outcomes of racism and racial bullying for individuals, schools and communities; exploring the enablers and obstacles associated with bystander responses to racism and racial bullying; and by developing and piloting a school-based program to foster bystander responses to racism and racial bullying.Read moreRead less
Sounds of Empire: Popular Politics and Music in the Nineteenth Century. This research will critically locate Australia within a global system of cultural transmission and showcase a significant innovation in methodology through an interdisciplinary approach. This will provide an opportunity to bring to light Australia's role in the transmission of popular politics and culture to a broader international audience. It will make a direct and immediate contribution to Australian studies by examining ....Sounds of Empire: Popular Politics and Music in the Nineteenth Century. This research will critically locate Australia within a global system of cultural transmission and showcase a significant innovation in methodology through an interdisciplinary approach. This will provide an opportunity to bring to light Australia's role in the transmission of popular politics and culture to a broader international audience. It will make a direct and immediate contribution to Australian studies by examining in depth the transmission, adaption and encounter of musics in the making of the nation. Many of the ideas that shape our modern democracy were brought informally in speeches and songs. A better understanding of the ways and means of their transmission brings us to a deeper appreciation of Australia's past and present.Read moreRead less
Intercommunal and Translocal Space in Fairfield: Tracking Indochinese Australian Lives. While providing important socio-cultural information about Lao, Cambodian and Vietnamese communities in western Sydney, this project takes an innovative approach to the study of 'minority' communities in multicultural societies. By locating itself at the points of contact between communities, the proposed research recognises that subjects are often members of multiple social groups, and that they shift back a ....Intercommunal and Translocal Space in Fairfield: Tracking Indochinese Australian Lives. While providing important socio-cultural information about Lao, Cambodian and Vietnamese communities in western Sydney, this project takes an innovative approach to the study of 'minority' communities in multicultural societies. By locating itself at the points of contact between communities, the proposed research recognises that subjects are often members of multiple social groups, and that they shift back and forth across their boundaries. Such a perspective enables one to avoid the fallacy of locating 'the multicultural' in minority subjects/cultures, and thus 'multicultural problems' within particular 'problem communities'. Rather, it situates the multicultural in the interstices between 'mainstream' and 'minority' AustraliaRead moreRead less
Authenticity: Globalisation and Indigenous Culture. Who speaks for the Fourth World? Why is there an obsession with 'authenticity' whenever Indigenous people are being discussed? This study explores those questions by examining a combination of sources, ranging from international museum collections to the advertising campaigns of multinational companies; from literature to the cultural festivals of the Olympic Games. The research is original, comparative, empirical. It explores the intersectio ....Authenticity: Globalisation and Indigenous Culture. Who speaks for the Fourth World? Why is there an obsession with 'authenticity' whenever Indigenous people are being discussed? This study explores those questions by examining a combination of sources, ranging from international museum collections to the advertising campaigns of multinational companies; from literature to the cultural festivals of the Olympic Games. The research is original, comparative, empirical. It explores the intersections between postcolonial and cultural studies to speak -- not for Indigenous peoples -- but to the non-Indigenous representation of First Nations. Why? Because this provides key insights into the future of race relations in western democracies.Read moreRead less
Anglos Abroad: Memoirs of Immersion in a Foreign Language and Culture. A study of Anglophone narratives of language immersion offers a significant intellectual resource for thinking about ways in which Australian non-immigrant selves are shaped by culture and language: an issue with important implications for just practises within a wide range of national institutions and agencies, including education, immigration and social work. It thus contributes to the priority goal of strengthening Austral ....Anglos Abroad: Memoirs of Immersion in a Foreign Language and Culture. A study of Anglophone narratives of language immersion offers a significant intellectual resource for thinking about ways in which Australian non-immigrant selves are shaped by culture and language: an issue with important implications for just practises within a wide range of national institutions and agencies, including education, immigration and social work. It thus contributes to the priority goal of strengthening Australia's social and economic fabric (Research Priority 2). It also contributes to enhancing our capacity to interpret and engage with our region and the world through a greater understanding of other languages and cultures (Research Priority 4).Read moreRead less