Multistage Vaccines For The Prevention Of Tuberculosis
Funder
National Health and Medical Research Council
Funding Amount
$884,290.00
Summary
Almost two million people die from tuberculosis (TB) each year. The current vaccine, BCG, is ineffective at controlling TB and the type of immune response needed to protect against the disease is poorly understood. We have discovered new antigens of the TB bacterium, and we will combine them with novel delivery strategies to develop new TB vaccines. We will also determine the type of immune response needed to protect against TB, which will aid progression of vaccines into clinical trials.
The Impact Of The Neonatal Gut Microbiome On Specific And Nonspecific Vaccine Responses.
Funder
National Health and Medical Research Council
Funding Amount
$661,496.00
Summary
Humans are colonised by a large and diverse group of microorganisms, collectively known as the microbiome. The gut microbiome, in particular, hosts an enormous abundance and diversity of bacteria, which perform a range of essential beneficial functions. Our study will investigate whether disruption of the gut microbiome in newborns, for example through antibiotic usage or maternal diet, leads to an impairment of subsequent immune responses to childhood immunisations.
Immunomodulatory Vaccines In The Treatment Of Peanut Allergy
Funder
National Health and Medical Research Council
Funding Amount
$678,899.00
Summary
Peanut allergy is the most common cause of food-induced anaphylactic reactions in Australia and is a major burden to our healthcare system. Current clinical practice advice dietary avoidance to prevent fatal anaphylactic responses. We propose the use of an immunomodulatory vaccine to re-write the immune response to peanut antigens, from an allergic to a tolerant phenotype. This study will provide novel insights into rational approaches for manipulating immune memory to food allergens.
A new look at modelling population heterogeneity in econometric study. This research will advance existing quantitative techniques in economic study. New theoretical results will help enhance Australian research reputations. The innovative techniques developed in this project will be demonstrated to study labour force participation of people with disabilities in Australia. Findings of the empirical study will help governments in providing financial assistance to affected families and addressing ....A new look at modelling population heterogeneity in econometric study. This research will advance existing quantitative techniques in economic study. New theoretical results will help enhance Australian research reputations. The innovative techniques developed in this project will be demonstrated to study labour force participation of people with disabilities in Australia. Findings of the empirical study will help governments in providing financial assistance to affected families and addressing the issue of labour shortage in Australia. Furthermore the participation of a high profile international researcher will benefit the local research community and provide a research training opportunity for local postgraduate students.Read moreRead less
In the shadow of Singapore: The limits of transnationalism in Insular Riau. This project will contribute to the process of safeguarding Australia, through a better understanding of our nearest neighbours. An enhanced understanding of nationalism and regionalism in Southeast Asia is central to the maintenance of effective bilateral and multilateral relations between Australia and its near neighbours. Cross-border tension between our ASEAN neighbours is potentially a problem for Australia, and thu ....In the shadow of Singapore: The limits of transnationalism in Insular Riau. This project will contribute to the process of safeguarding Australia, through a better understanding of our nearest neighbours. An enhanced understanding of nationalism and regionalism in Southeast Asia is central to the maintenance of effective bilateral and multilateral relations between Australia and its near neighbours. Cross-border tension between our ASEAN neighbours is potentially a problem for Australia, and thus of political and economic concern to all Australians.Read moreRead less
From Stranger to Citizen: Migration, Modernisation and Racialisation in the Making of the New Australian. The project addresses an important question: How can Australians continue to reap the benefits of cultural diversity while building a strong sense of national cohesion with which to engage productively with the rest of the world? Refugees from developing countries appear to pose a particular challenge to integration into Australian society. A close examination of the contact zone where newco ....From Stranger to Citizen: Migration, Modernisation and Racialisation in the Making of the New Australian. The project addresses an important question: How can Australians continue to reap the benefits of cultural diversity while building a strong sense of national cohesion with which to engage productively with the rest of the world? Refugees from developing countries appear to pose a particular challenge to integration into Australian society. A close examination of the contact zone where newcomers interact with service providers will result in a better understanding of citizen-making processes and facilitate the improvement of policies and their implementation to facilitate faster and deeper integration of migrants and refugees from developing countries into Australian society.Read moreRead less
Nonlinear spatial and spatiotemporal econometrics: theory with applications. Modern societies like Australia have major challenges in the forecasting, measuring and managing of risks associated with global economic and environmental/climate changes. These tasks require advanced econometric techniques in modelling and forecasting of complex nonlinear spatiotemporal variability in economic and social systems. This project will develop frontier econometric technologies that enable more accurate eco ....Nonlinear spatial and spatiotemporal econometrics: theory with applications. Modern societies like Australia have major challenges in the forecasting, measuring and managing of risks associated with global economic and environmental/climate changes. These tasks require advanced econometric techniques in modelling and forecasting of complex nonlinear spatiotemporal variability in economic and social systems. This project will develop frontier econometric technologies that enable more accurate economic and climate forecasts. The tools produced will provide Australia's scientists and policy-makers with a greater capacity to manage the risks associated with these challenges. A side-benefit of the research will be high-quality publications that enhance the nation's reputation in this cutting edge research.Read moreRead less
Nonlinear Panel Data Econometrics: Theory and Practice. This research addresses the ARC National Research Priorities Goal of 'An Environmentally Sustainable Australia', specifically 'Reducing and capturing emissions in transport and energy generation'. Avoiding, managing, and/or adapting to the climate change impacts is now the most pressing global environmental problem. This project will produce tangible and original insights into policy options for institutional adjustment to future climate ....Nonlinear Panel Data Econometrics: Theory and Practice. This research addresses the ARC National Research Priorities Goal of 'An Environmentally Sustainable Australia', specifically 'Reducing and capturing emissions in transport and energy generation'. Avoiding, managing, and/or adapting to the climate change impacts is now the most pressing global environmental problem. This project will produce tangible and original insights into policy options for institutional adjustment to future climate change in Australia; will provide insight into the scope for positive community behavioural change; and possible transformations in Australian social debate to maximise adaptive capacity. It will also strengthen and produce original conceptual approaches and research methods.Read moreRead less
Changing patterns of migration from Afghanistan with implications for Australia. As a signatory to the UN Refugee Convention, a major location for the resettlement of refugees and a major player in the international system with a stated commitment to humanitarian issues, Australia is well placed to play a lead role in promoting more effective solutions to the plight of refugees. This study is designed to contribute to that objective through research of one of the world's most important refugee g ....Changing patterns of migration from Afghanistan with implications for Australia. As a signatory to the UN Refugee Convention, a major location for the resettlement of refugees and a major player in the international system with a stated commitment to humanitarian issues, Australia is well placed to play a lead role in promoting more effective solutions to the plight of refugees. This study is designed to contribute to that objective through research of one of the world's most important refugee groups, the Afghans. It will also provide a better understanding of the security issues involved in refugee migration.Read moreRead less
The limited promise of 'equality biographies': Young Australians negotiate modern gendered identities, family and citizenship engagements in a divided society. Apart from its contribution to the international sociological debate concerning the individualization thesis, the project will contribute to pressing policy issues, ie. declining fertility, accessibility of abortion, appropriate childcare, humane immigration policies in a world with millions of refugees and reconciliation. Based on an em ....The limited promise of 'equality biographies': Young Australians negotiate modern gendered identities, family and citizenship engagements in a divided society. Apart from its contribution to the international sociological debate concerning the individualization thesis, the project will contribute to pressing policy issues, ie. declining fertility, accessibility of abortion, appropriate childcare, humane immigration policies in a world with millions of refugees and reconciliation. Based on an empirically grounded analysis in a rich qualitative data set revealing how young Australians see themselves negotiating family, work and citizenship, the project will construct the vocabularies by which young people locate themselves in the community. The results will make contributions to policy debates by suggesting changes that are responsive to the needs and aspirations of the citizens of the future.Read moreRead less