Deep time in the deep Earth: using trace element diffusivities to constrain durations of deep Earth processes. Evaluation of deep Earth resources requires knowing how long geological processes took, some record of which is often preserved by gradients in the chemical compositions of minerals. Experiments at very high temperatures and pressures will determine how this evidence can be used to constrain the durations of a rich variety of geological processes.
Voltage-dependent structural changes in voltage-gated sodium channels. This project aims to provide insights into the structural rearrangements experienced by Nav channels, which are key components of animal nervous systems. Voltage-gated sodium (Nav) channels initiate action potentials in excitable cells. They open in response to membrane depolarisation then rapidly inactivate. Eukaryotic Nav channels contain four unique voltage-sensor domains (VSDs) that control how the channel responds to mem ....Voltage-dependent structural changes in voltage-gated sodium channels. This project aims to provide insights into the structural rearrangements experienced by Nav channels, which are key components of animal nervous systems. Voltage-gated sodium (Nav) channels initiate action potentials in excitable cells. They open in response to membrane depolarisation then rapidly inactivate. Eukaryotic Nav channels contain four unique voltage-sensor domains (VSDs) that control how the channel responds to membrane potential changes. Recently reported crystal structures of bacterial Nav channels have greatly advanced the field, but these channels contain four identical VSDs and have different inactivation properties. Thus, much remains to be learnt about the conformational plasticity of eukaryotic Nav channel VSDs. The project plans to use animal toxins to capture eukaryotic VSDs in defined states of the gating cycle for detailed structural analysis using nuclear magnetic resonance and X-ray crystallography.Read moreRead less
The geochemistry of rare earth elements in carbonate melts. This project aims to determine why deposits of rare earth elements, which are critical for modern devices and technologies such as phones, tablets and plasma screens, are associated with carbonate magmas. The global supply of these critical metals is geopolitically unstable and, although Australia has significant reserves, there is very limited production. By improving our understanding of the geochemical behaviour of the rare earths th ....The geochemistry of rare earth elements in carbonate melts. This project aims to determine why deposits of rare earth elements, which are critical for modern devices and technologies such as phones, tablets and plasma screens, are associated with carbonate magmas. The global supply of these critical metals is geopolitically unstable and, although Australia has significant reserves, there is very limited production. By improving our understanding of the geochemical behaviour of the rare earths this project aims to develop new reverse-engineering methods for their extraction, which will improve the security of supply of these elements and enhance Australia's role in high-tech industries. The project will enhance the profitability of the Australian resources sector through improved extraction economics and will secure the supply of these critical metals for Australian high-tech industries and export. The outcomes will be targeted initially at junior resource companies that are not yet profitable.Read moreRead less