The Role Of Seipin In Adipocyte Development And Lipid Droplet Formation
Funder
National Health and Medical Research Council
Funding Amount
$376,258.00
Summary
The prevalence of obesity and its related disorders has reached an alarming level in Australia and other developed countries. Obesity is characterized by the accumulation of fully-differentiated adipocytes loaded with lipid droplets (LDs). We aim to characterize seipin, which regulate both lipid droplet formation and adipocyte differentiation. Results from our proposed studies may offer novel therapeutic strategies against human obesity.
The Role Of Phosphatidic Acid In Lipid Storage And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$496,169.00
Summary
The prevalence of obesity and its related disorders has reached an alarming level in Australia and other developed countries. Obesity is characterized by the accumulation of fully-differentiated adipocytes loaded with lipid droplets (LDs). We aim to examine the role of phosphatidic acid in lipid droplet formation and adipocyte differentiation. Results from our proposed studies may offer novel therapeutic strategies against human obesity and type II diabetes.
Molecular Characterization Of SEIPIN Function: Implications For Lipogenesis And Adipogenesis
Funder
National Health and Medical Research Council
Funding Amount
$767,468.00
Summary
Obesity and type II diabetes have become a major health threat to Australians. This project aims to understand how fat is made and stored. Results from this research may lead to novel therapeutic strategies against obesity and diabetes.
Metabolic Wiring In Adipocytes - Unique Role In Maintaining Long-term Health
Funder
National Health and Medical Research Council
Funding Amount
$1,077,886.00
Summary
Fat cell metabolism is wired to optimize the cell’s ability to make and store lipid while programming the cell to fulfil its function in whole body metabolism. We will: 1) map fat cell metabolism under optimal and insulin resistant conditions; 2) explore the role of 3 nodes in his metabolic circuit predicted as control points; 3) use a novel genetically engineered mouse model to explore the functional significance of fat cell metabolism in whole body insulin sensitivity.
The Role Of Oxyterol-binding Protein-related Protein 5 (ORP5) In Cellular Lipid Storage And Whole Body Energy Homeostasis
Funder
National Health and Medical Research Council
Funding Amount
$758,472.00
Summary
Fat is stored in the form of lipid droplets in our cells and body. However, our knowledge on how lipid droplets grow and are broken down is very limited. We aim to investigate how lipids are delivered to the lipid droplets and how lipid droplets can store lipids efficiently. Results from the proposed work will provide fundamental new knowledge on how our cells store and utilize fat. Such knowledge may be translated into therapeutic strategies one day against obesity and diabetes.