The National First Nations Research Network will mark a transformation in First Peoples livelihoods and Health Equity. Delivered and led by Indigenous Peoples for Indigenous Peoples, guided by self-determination, this Network will nurture culturally safe environments, connect expertise, catalyse research methods, training and development. The Network will create career pathways to achieve national capability and generational growth, for sustained health and wellbeing of our communities.
The impact of copper on protein turnover. This project aims to elaborate a novel discovery by the research team, that a conserved copper-binding site in a group of conserved conjugating enzymes promotes ubiquitination of a range of essential proteins leading to their rapid degradation, which might be a means of maintaining copper homeostasis. This project will employ a range of integrated physicochemical, biochemical and cell biology approaches to illuminate the molecular nature of this copper a ....The impact of copper on protein turnover. This project aims to elaborate a novel discovery by the research team, that a conserved copper-binding site in a group of conserved conjugating enzymes promotes ubiquitination of a range of essential proteins leading to their rapid degradation, which might be a means of maintaining copper homeostasis. This project will employ a range of integrated physicochemical, biochemical and cell biology approaches to illuminate the molecular nature of this copper action on the enzyme and its partners. Expected outcomes include an analytical understanding of the molecular mechanisms of this process, and enhanced interdisciplinary collaboration between experts. Potential benefits include new strategies to intervene in copper-related disorders of aging.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100130
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
New Biomolecular Capabilities for the Melbourne Magnetic Resonance Facility. The project aims to integrate new instrumentation, which does not currently exist in Australia, into the Melbourne Biomolecular Nuclear Magnetic Resonance (NMR) facility. This will introduce new capabilities to the Australian NMR community to characterise important biological molecular interactions at low concentrations. This project expects to support existing areas of research strength with new approaches across inter ....New Biomolecular Capabilities for the Melbourne Magnetic Resonance Facility. The project aims to integrate new instrumentation, which does not currently exist in Australia, into the Melbourne Biomolecular Nuclear Magnetic Resonance (NMR) facility. This will introduce new capabilities to the Australian NMR community to characterise important biological molecular interactions at low concentrations. This project expects to support existing areas of research strength with new approaches across interdisciplinary research programs in biochemistry, structural biology, medicinal and natural product chemistry. Expected outcomes from a range of research with a variety of partners will underpin new, potentially commercially valuable, applications across the chemical, pharmaceutical, agricultural or manufacturing industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100134
Funder
Australian Research Council
Funding Amount
$796,206.00
Summary
Super-resolution platform to accelerate biological and molecular research. This application aims to establish a new molecular analysis platform integrating a microfluid capillary electrophoresis interface directly to a mass spectrometer with advanced data scanning technology. This enables label-free detection, quantitation and characterisation of intact proteins, lipids and metabolites with unprecedented sensitivity, resolution and throughput. It will enhance ARC projects spanning natural produc ....Super-resolution platform to accelerate biological and molecular research. This application aims to establish a new molecular analysis platform integrating a microfluid capillary electrophoresis interface directly to a mass spectrometer with advanced data scanning technology. This enables label-free detection, quantitation and characterisation of intact proteins, lipids and metabolites with unprecedented sensitivity, resolution and throughput. It will enhance ARC projects spanning natural product discovery, biotechnology, agriculture, and animal, plant and marine biology, as well as single-cell proteomics, lipidomics and metabolomics. It will ensure Australia remains at the forefront of molecular and biological research and create new training and collaborative opportunities both nationally and internationally.Read moreRead less
A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent ....A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent enteric parasite identified globally in dogs. Infection rates can be as high as 75% in puppies. Current treatments are failing due to poor efficacy, resistance and poor adherence to treatment schedules. We have identified a novel, extremely rapid acting series of compounds capable of single shot eradication of Giardia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100170
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
Bioaffinity mass spectrometry infrastructure to identify small molecules binding to therapeutic targets. The development of anti-infective therapies is challenging because the underlying biology and biochemistry of pathogen virulence is not yet completely understood. This mass spectrometer facility will be used to identify small molecules suited for development into new therapies for malaria, tuberculosis and HIV.
Nicotinic receptor structure and function probed with conotoxins. Nicotinic receptors are intrinsic membrane proteins that play a role in communication in excitable cells, particularly in the nervous system. The primary goals of this project are to define the structural and functional determinants of nicotinic-conotoxin interactions at a molecular level, and develop new selective probes that advance neurophysiological research. The diversity and distribution of nicotinic receptor subtypes being ....Nicotinic receptor structure and function probed with conotoxins. Nicotinic receptors are intrinsic membrane proteins that play a role in communication in excitable cells, particularly in the nervous system. The primary goals of this project are to define the structural and functional determinants of nicotinic-conotoxin interactions at a molecular level, and develop new selective probes that advance neurophysiological research. The diversity and distribution of nicotinic receptor subtypes being uncovered through molecular biology and selective conotoxin probes presents an exciting opportunity for the discovery of new therapeutic agents.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100075
Funder
Australian Research Council
Funding Amount
$315,000.00
Summary
Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility wh ....Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility while reducing cost. The expected benefits will advance the elucidation of molecular mechanisms involved in complex biological phenomena. The benefits of this are substantial, including reduction in test compound and reagents, which in turn reduces laboratory costs, conserves cells and increases data quality.Read moreRead less
ARC Centre of Excellence for the Elimination of Violence Against Women. ARC Centre of Excellence for the Elimination of Violence Against Women. Eliminating violence against women is one of the major challenges of the 21st century. Awareness of the problem has grown exponentially, but solutions to it have not. This Centre aims to transform our understanding of the problem by examining the structural drivers that cause and compound violence against women, and pioneering new, evidence-based approac ....ARC Centre of Excellence for the Elimination of Violence Against Women. ARC Centre of Excellence for the Elimination of Violence Against Women. Eliminating violence against women is one of the major challenges of the 21st century. Awareness of the problem has grown exponentially, but solutions to it have not. This Centre aims to transform our understanding of the problem by examining the structural drivers that cause and compound violence against women, and pioneering new, evidence-based approaches to radically improve policy and practice across Australia and the Indo-Pacific. The Centre mobilises survivor-centric and Indigenous methodologies, interdisciplinary collaborations, and Indo-Pacific partnerships to deliver scalable approaches to eliminate violence against women across the legal, security, economic, health, and political systems of Australia and the region.Read moreRead less