A Novel Mechanism For Sustained Proliferation Of Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$565,881.00
Summary
We have found that some tumours use a previously unknown strategy for evading the normal limits on cellular proliferation. We will analyse the molecular details of this mechanism in order to (i) understand how it works, (ii) devise a diagnostic test, and (iii) lay the foundations for developing treatments that specifically target this type of cancer.
Sex Chromosome Instability In Disorders Of Development
Funder
National Health and Medical Research Council
Funding Amount
$627,633.00
Summary
Chromosomes must be copied and distributed faultlessly into the newly dividing cells for normal development to occur. Factors that affect this process are often associated with health problems such as birth disorders, cancer, premature aging and infertility. This project plans to identify genetic factors that compromise the faithful transmission of chromosomes from cell to cell. Results gained from this project will greatly assist in the diagnosis of chromosome-related disorders.