C-Jun N-terminal Kinase Regulation Of Microtubule Destabilizer, Stathmin - A Novel Cytoprotective Pathway
Funder
National Health and Medical Research Council
Funding Amount
$550,230.00
Summary
The loss of heart muscle cells during heart attack and heart failure worsens the severity of heart disease. We will study how to protect heart muscle cells by identifying the molecules involved in controlling survival responses. We will use this knowledge to prevent heart muscle cells from dying when exposed to a range of normally harmful conditions. Our study has the potential to prevent heart muscle cell loss, improve heart function and prevent muscle damage in heart disease.
The Regulation Of Pleiotropic Responses By Bidentate Motifs Embedded In The Fibroblast Growth Factor Receptors
Funder
National Health and Medical Research Council
Funding Amount
$489,336.00
Summary
Cells in our bodies are able to accomplish an impressive array of functions. Diffusible factors (called growth factors) are important in regulating diverse cellular functions. We have identified a new molecular switch inside cells that acts as a master controller of cellular functions. This molecular switch relays information to instruct specific cellular functions. We have shown that these molecular switches are short-circuited in breast cancer promoting cell growth and survival.
Analysis Of The Functions Of A Novel Class Of Ubiquitin E3 Ligases In TNF Signalling In Vivo
Funder
National Health and Medical Research Council
Funding Amount
$568,861.00
Summary
The aim of this project to discover the role of a novel ubiquitin ligase complex that regulates TNF superfamily signalling. It will increase understanding of the TNF pathway and improve our ability to manipulate it pharmacologically, or otherwise, in the large number of debilitating human diseases including Rheumatoid Arthritis and Crohn's disease that result from aberrant TNF signalling. Because of the role of TNF in tumorigenesis it may also contribute to novel anti-cancer treatments.