Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Spinal Cord Injury Pain: Understanding Mechanisms To Develop Treatments
Funder
National Health and Medical Research Council
Funding Amount
$597,675.00
Summary
Spinal cord injury has devastating effects on health and quality of life. Many of the major consequences of injury, such as chronic pain and loss of voluntary voiding, are "invisible" – i.e., they are not as visible as limitations of mobility. Our study aims to define the neurobiological changes that cause development of persistent pain after spinal cord injury and use pharmacological tools to attenuate the development of pain.
Accelerated Finite-time Learning and Control in Cyber-Physical Systems. Efficient learning and control in cyber-physical systems such as smart grids and robotic systems are very important for achieving economic and social benefits. This project aims to establish a breakthrough accelerated finite-time dynamics theory and technology to assist in delivering efficient learning and control. Expected outcomes include new distributed accelerated finite-time dynamics based learning and control algorithm ....Accelerated Finite-time Learning and Control in Cyber-Physical Systems. Efficient learning and control in cyber-physical systems such as smart grids and robotic systems are very important for achieving economic and social benefits. This project aims to establish a breakthrough accelerated finite-time dynamics theory and technology to assist in delivering efficient learning and control. Expected outcomes include new distributed accelerated finite-time dynamics based learning and control algorithms and tools for optimal operations in cyber-physical systems. This should provide significant benefits including a practical technology for industry applications in smart grids and robotic systems, and training of the next generation engineers in this technology for Australia.Read moreRead less
Exploiting Geometries of Learning for Fast, Adaptive and Robust AI. This project aims to uniquely exploit geometric manifolds in deep learning to advance the frontier of Artificial Intelligence (AI) research and applications in cybersecurity and general cognitive tasks. It expects to develop new theories, algorithms, tools, and technologies for machine learning systems that are fast, adaptive, lifelong and robust, even with limited supervision. Expected outcomes will enhance Australia's capabili ....Exploiting Geometries of Learning for Fast, Adaptive and Robust AI. This project aims to uniquely exploit geometric manifolds in deep learning to advance the frontier of Artificial Intelligence (AI) research and applications in cybersecurity and general cognitive tasks. It expects to develop new theories, algorithms, tools, and technologies for machine learning systems that are fast, adaptive, lifelong and robust, even with limited supervision. Expected outcomes will enhance Australia's capability and competitiveness in AI, and deliver robust and trustworthy learning technology. The project should provide significant benefits not only in advancing scientific and translational knowledge but also in accelerating AI innovations, safeguarding cyberspace, and reducing the burden on defence expenses in Australia.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.