The long-term side effects of renal denervation are unknown. This project is designed to (1) investigate the potential atherosclerosis-promoting effect of renal denervation, and (2) to study the effectiveness of anti-inflammatory drugs to minimize this potential side effect. Ultimately, this project may improve the beneficial effects and minimize the potential side effects of renal denervation by routinely treating renal denervated patients with anti-inflammatory drugs.
Renal Denervation To Improve Outcomes In Patients With End-stage Renal Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,028,558.00
Summary
End stage renal disease is associated with excess cardiovascular morbidity and mortality. Activation of sympathetic nerves plays an important role in this scenario. We have pioneered a novel catheter-based approach using radiofrequency-energy to disrupt these nerves and we now aim to assess the mechanisms and consequences of applying this novel technology in patients with end-stage renal disease.
Inadequately controlled blood pressure remains the leading cause of death world wide despite the availability of numerous effective drugs. We have successfully pioneered a catheter-based approach using radiofrequency-energy to disrupt renal nerves and lower blood pressure in patients with resistance to conventional drug treatment. We now aim to test the role of this ground-breaking technology as a potential cure (blood pressure control without antihypertensive medication) for hypertension.