Development Of Antimicrobial Peptides Targeting Oral Pathogenic Bacteria
Funder
National Health and Medical Research Council
Funding Amount
$663,350.00
Summary
The bacterial associated oral diseases; periodontitis and caries are major public health problems. The prevalence of these diseases and increasing bacterial antibiotic resistance has meant there is a need to develop new therapies. This project addresses this by modifying a novel class of antibiotics/antiseptics �antimicrobial peptides� to target oral bacteria and testing them using a newly developed screening method. This project will lead to new therapies for periodontitis and caries.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560705
Funder
Australian Research Council
Funding Amount
$825,000.00
Summary
Advanced Deformation Simulation Laboratory. For Australia to maintain its position as a world leader in the science of metals processing it must have the capability for state-of-the-art physical simulation. The present proposal is for the purchase and installation of two leading edge simulation tools: a high rate/short inter-pass hot deformation simulator and a hot equal channel angular extrusion press. Advanced hot deformation simulation is required for the development and optimisation of "fast ....Advanced Deformation Simulation Laboratory. For Australia to maintain its position as a world leader in the science of metals processing it must have the capability for state-of-the-art physical simulation. The present proposal is for the purchase and installation of two leading edge simulation tools: a high rate/short inter-pass hot deformation simulator and a hot equal channel angular extrusion press. Advanced hot deformation simulation is required for the development and optimisation of "fast" industrial processes and for understanding the complex microstructural reactions associated with them. High temperature extrusion is required for the development of ultra-fine and nano-grained light metals.Read moreRead less
Retrofit of Steel Connections subject to Fatigue Load by Utilizing carbon fibre reinforced polymeric (CFRP) and Modified Epoxy Structural Adhesives. The proposed research project will challenge conventional methods of repairing or strengthening steel structures by using an advanced material (CFRP) together with modified epoxy structural adhesives. It will not only provide reliable retrofitting of existing structures but will also build safe, more economic and smarter steel structures. It will co ....Retrofit of Steel Connections subject to Fatigue Load by Utilizing carbon fibre reinforced polymeric (CFRP) and Modified Epoxy Structural Adhesives. The proposed research project will challenge conventional methods of repairing or strengthening steel structures by using an advanced material (CFRP) together with modified epoxy structural adhesives. It will not only provide reliable retrofitting of existing structures but will also build safe, more economic and smarter steel structures. It will contribute to the socio-economic wellbeing of Australia, including road and railway infrastructure, offshore, mining and recreation industries, increasing the international competitiveness of the Australian steel industry and infrastructure maintenance capability. Australia will be better positioned in the region for potential technology transfer to Asian and surrounding countries.Read moreRead less
CFRP (Carbon Fibre Reinforced Polymer) Strengthening of Steel Structures. The research will produce a breakthrough in understanding the bond characteristics between CFRP and steel. It will develop strengthening techniques for steel structures. The project will contribute to improved cost effectiveness and safety of steel structures thereby contributing to the socio-economic well-being of Australia including the road, offshore, building and mining industries. It will increase the international co ....CFRP (Carbon Fibre Reinforced Polymer) Strengthening of Steel Structures. The research will produce a breakthrough in understanding the bond characteristics between CFRP and steel. It will develop strengthening techniques for steel structures. The project will contribute to improved cost effectiveness and safety of steel structures thereby contributing to the socio-economic well-being of Australia including the road, offshore, building and mining industries. It will increase the international competitiveness of the Australian steel industry and Australia's infrastructure maintenance capability. Furthermore, Australia will be better positioned for potential technology transfer to Asian countries in this technical area.Read moreRead less
Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical ev ....Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical evidence on the underlying mechanisms, alternative protocols, delivery systems enable to optimise the treatment. The scientific insights into arresting/repairing damage processes will provide critical data for developing minimal intervention protocols for pediatric and geriatric populations.Read moreRead less
Development of economical beam-column connections for robust composite steel-concrete structural frames. The proposed construction systems will offer a competitive and more robust alternative for developers, building owners and occupants. The successful development of the proposed construction systems will lead to an increased market for blind bolts, steel circular hollow sections, steel Universal Beams and metal decking. An added benefit of the proposed systems is an anticipated improvement in ....Development of economical beam-column connections for robust composite steel-concrete structural frames. The proposed construction systems will offer a competitive and more robust alternative for developers, building owners and occupants. The successful development of the proposed construction systems will lead to an increased market for blind bolts, steel circular hollow sections, steel Universal Beams and metal decking. An added benefit of the proposed systems is an anticipated improvement in performance, relative to existing systems, under low probability, high consequence events such as 2500-year return period level earthquakes (in the relevant region) or blast loading. These unique and innovative structural solutions should drive the competitive advantage of Australian engineers in international markets.Read moreRead less
Debonding Failure in CFRP Strengthened Steel Structures. The research will make a breakthrough in understanding the bond characteristics between CFRP and steel. It will enhance the capacity of Australian researchers to participate in a new cutting-edge research area, and help create a vibrant new industry for strengthening steel structures. The project will contribute to improved cost efficiency and safety of steel structures thereby contributing to the socio-economic well being of Australia inc ....Debonding Failure in CFRP Strengthened Steel Structures. The research will make a breakthrough in understanding the bond characteristics between CFRP and steel. It will enhance the capacity of Australian researchers to participate in a new cutting-edge research area, and help create a vibrant new industry for strengthening steel structures. The project will contribute to improved cost efficiency and safety of steel structures thereby contributing to the socio-economic well being of Australia including road, offshore, building and mining industries. It will increase the international competitiveness of Australian steel industry and infrastructure maintenance capability. Australia will be better positioned in this region for potential technology transfer to Asian countries.Read moreRead less
Reducing tool wear through novel surface treatments and improved lubrication. High strength steels can be used to make vehicles lighter and safer but forming them into parts requires large forces. This can lead to problems with tool wear and poor surface finish. This project will lead to improved understanding of what makes a lubricant effective and how to design a tool surface to reduce wear. This new knowledge will lead to improved tool designs and products. The competitiveness of the Australi ....Reducing tool wear through novel surface treatments and improved lubrication. High strength steels can be used to make vehicles lighter and safer but forming them into parts requires large forces. This can lead to problems with tool wear and poor surface finish. This project will lead to improved understanding of what makes a lubricant effective and how to design a tool surface to reduce wear. This new knowledge will lead to improved tool designs and products. The competitiveness of the Australian automotive manufacturing industry will be improved and there will be benefits for the local tooling industry, especially in the competition for overseas markets.Read moreRead less
Modelling of Nanostructuring of Bulk Metallic Materials by Severe Plastic Deformation. The use of ultrafine grained alloys is expected to lead to significant breakthroughs in relation to fuel-efficient cars, light weight/high strength designs in aerospace and structural applications, and bio-medical implants. It will provide a wider market for such metals and create niche applications in domestic and export manufacturing industry. The development of technologically viable processes of nanostruct ....Modelling of Nanostructuring of Bulk Metallic Materials by Severe Plastic Deformation. The use of ultrafine grained alloys is expected to lead to significant breakthroughs in relation to fuel-efficient cars, light weight/high strength designs in aerospace and structural applications, and bio-medical implants. It will provide a wider market for such metals and create niche applications in domestic and export manufacturing industry. The development of technologically viable processes of nanostructuring hinges on the fundamental understanding of the fundamental mechanisms of microstructure and texture development. The knowledge base to be developed through this project will bring Australia to the international forefront in the area of structural nanomaterials and prepare the ground for future frontier technologies. Read moreRead less