Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and ....Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and molecular analytes. By performing research to further understand and develop this tuneable effect, this project aims to build and test a new platform technology to enable highly efficient capture and specific detection of low concentration pathogenic molecules and circulating tumour cells (CTCs).Read moreRead less
Children's Intergroup Prejudice: The Roles of Cognitive Representations and Self-presentation. Research indicates that intergroup prejudice remains a problem in most Australian schools. For example, children as young as 5-6 years assign negative attributes to indigenous Australians and Pacific Islander children, they prefer not to play with these children, and they do not even want them living nearby. The proposed research will examine the possible basis of age effects in these attitudes. It wi ....Children's Intergroup Prejudice: The Roles of Cognitive Representations and Self-presentation. Research indicates that intergroup prejudice remains a problem in most Australian schools. For example, children as young as 5-6 years assign negative attributes to indigenous Australians and Pacific Islander children, they prefer not to play with these children, and they do not even want them living nearby. The proposed research will examine the possible basis of age effects in these attitudes. It will have a substantial national benefit because it will increase our understanding of this insidious social phenomenon and provide a basis for developing an intervention that will minimise a problem that has the potential to devastate community relations.
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Determinants of Audio-Visual effects in degraded and non-degraded speech. Seeing a speaker's face can affect the perception of their speech in a number of ways. This project proposes a detailed comparison of factors that affect Audio-Visual (AV) facilitation of degraded speech detection and identification. Detection-based tasks should be more sensitive to signal based correlations whereas identification-based effects more sensitive to complementary information. The significance of the current pr ....Determinants of Audio-Visual effects in degraded and non-degraded speech. Seeing a speaker's face can affect the perception of their speech in a number of ways. This project proposes a detailed comparison of factors that affect Audio-Visual (AV) facilitation of degraded speech detection and identification. Detection-based tasks should be more sensitive to signal based correlations whereas identification-based effects more sensitive to complementary information. The significance of the current proposal is that it offers both a strategy and a connected series of experiments for determining key behavioural constraints on AV speech integration. Understanding AV interactions will build links between neurophysiological processes and coherent perception and have important implications for AV application.Read moreRead less
From autobiographical memory to collective memory: An interdisciplinary study of individual and group cognition. Remembering our past is crucial to our identity and well-being, both as individuals and in groups. Investigating the role of social groups in memory, this project offers 4 benefits: (1) it builds Australia's capacity for high-level, innovative memory research; (2) it pioneers an interdisciplinary approach, genuinely integrating philosophy and psychology, to strengthen Australia's inte ....From autobiographical memory to collective memory: An interdisciplinary study of individual and group cognition. Remembering our past is crucial to our identity and well-being, both as individuals and in groups. Investigating the role of social groups in memory, this project offers 4 benefits: (1) it builds Australia's capacity for high-level, innovative memory research; (2) it pioneers an interdisciplinary approach, genuinely integrating philosophy and psychology, to strengthen Australia's international reputation in these fields; (3) it identifies social supports for healthy remembering, thus 'Promoting and Maintaining Good Health' ('Ageing well, ageing productively'); (4) it offers fresh, sophisticated ways to address public debates about the role of memory in productive, fulfilling lives, 'Strengthening Australia's social and economic fabric'.Read moreRead less
Optimising recall in children's testimony: The challenge of repeated questions. One of the threats to a healthy start in life for Australian children, and one which imposes substantial financial and emotional cost on the Australian community, is child abuse and neglect. This project addresses a key stumbling block in obtaining evidence from child victims/witnesses- their tendency to inconsistent testimony under repeated questioning. It seeks to understand the conditions under which inconsiste ....Optimising recall in children's testimony: The challenge of repeated questions. One of the threats to a healthy start in life for Australian children, and one which imposes substantial financial and emotional cost on the Australian community, is child abuse and neglect. This project addresses a key stumbling block in obtaining evidence from child victims/witnesses- their tendency to inconsistent testimony under repeated questioning. It seeks to understand the conditions under which inconsistency is minimized, as a basis for developing empirically and theoretically based ways to optimise the accuracy and legal utility of children's testimony. As a signatory to the United National Convention on the Rights of the Child (1990), Australia has a legal as well as a moral responsibility in this regard.Read moreRead less
The RGG/RG motif as an RNA chaperone: advancing CRISPR-Cas RNA technology. This project investigates the way in which protein molecules interact effectively with RNA molecules and also aims to enhance the CRISPR-Cas13a system for RNA detection. Innovative approaches will be used to test the role of a particular protein motif, called the RGG/RG motif, in remodelling RNA structure and enhancing the Cas13a protein. This knowledge is expected to shift our understanding of protein-RNA interactions th ....The RGG/RG motif as an RNA chaperone: advancing CRISPR-Cas RNA technology. This project investigates the way in which protein molecules interact effectively with RNA molecules and also aims to enhance the CRISPR-Cas13a system for RNA detection. Innovative approaches will be used to test the role of a particular protein motif, called the RGG/RG motif, in remodelling RNA structure and enhancing the Cas13a protein. This knowledge is expected to shift our understanding of protein-RNA interactions that are fundamental to almost every aspect of cell biology. The project is intended to benefit Australia through contributing to fundamental knowledge in the field, facilitating the development of new CRISPR-Cas biotechnologies for RNA detection and through the training of young researchers in frontier technologies. Read moreRead less
Children's difficulties in learning to read: Causes and consequences of poor letter-sound knowledge. This research will identify the causes and treatments of reading impairment in children. This will help the Government counter the effects of poor reading instruction in Australian schools (see the National Inquiry into the Teaching of Literacy). The outcomes will reveal how struggling readers should be taught in classrooms, and which treatments should be covered by the Reading Assistance Voucher ....Children's difficulties in learning to read: Causes and consequences of poor letter-sound knowledge. This research will identify the causes and treatments of reading impairment in children. This will help the Government counter the effects of poor reading instruction in Australian schools (see the National Inquiry into the Teaching of Literacy). The outcomes will reveal how struggling readers should be taught in classrooms, and which treatments should be covered by the Reading Assistance Voucher programme. Treating reading impairment in children will reduce the number of teenagers who attempt suicide, drop out of school, or abuse drugs to try and escape the failure that accompanies poor reading ability.Read moreRead less
A longitudinal study of the interaction of home and school language in three Aboriginal communities. The importance of language skills cannot be underestimated, and contribute to 'a healthy start to life'. In multilingual Indigenous communities, children must negotiate the complexities of different languages used for different purposes. This project will provide detailed insights into how children manage differences between home and school language, the kinds of problems they encounter when the ....A longitudinal study of the interaction of home and school language in three Aboriginal communities. The importance of language skills cannot be underestimated, and contribute to 'a healthy start to life'. In multilingual Indigenous communities, children must negotiate the complexities of different languages used for different purposes. This project will provide detailed insights into how children manage differences between home and school language, the kinds of problems they encounter when they enter the school system, and how their languages develop over the first four crucial years of school which provide the foundation for the children's future education. Their ability to manage the language of school underpins their ability to lead successful and engaged lives as adults. Read moreRead less
Tracking reading comprehension: What experts reveal about the mind. This project plans to use expert readers to provide a window on what defines optimal reading. Reading is a complex skill that requires precise coordination of cognition, perception and attention. By measuring skilled readers’ eye movements while they read sentences and short passages, the experiments are designed to investigate how individual differences in reading, spelling and vocabulary influence the timing and coordination o ....Tracking reading comprehension: What experts reveal about the mind. This project plans to use expert readers to provide a window on what defines optimal reading. Reading is a complex skill that requires precise coordination of cognition, perception and attention. By measuring skilled readers’ eye movements while they read sentences and short passages, the experiments are designed to investigate how individual differences in reading, spelling and vocabulary influence the timing and coordination of word identification and comprehension processes during normal reading and how this changes with a readers' goals. The results would distinguish between competing theories of how skilled readers balance word identification and comprehension processes, an issue that is critical to current debates about how reading should be taught.Read moreRead less
Self-assembled phases as effective and selective materials for analysis. This project aims to develop a suite of self-assembled amphiphilic molecules to form distinctive materials for analytical chemistry. The cost-effective, easy to prepare, selective and environmentally benign materials will be for non-volatile bioactive and chiral molecular targets that are commonly encountered every day or are difficult to study. The project will open a new research area and will further uplift the internati ....Self-assembled phases as effective and selective materials for analysis. This project aims to develop a suite of self-assembled amphiphilic molecules to form distinctive materials for analytical chemistry. The cost-effective, easy to prepare, selective and environmentally benign materials will be for non-volatile bioactive and chiral molecular targets that are commonly encountered every day or are difficult to study. The project will open a new research area and will further uplift the international standing of Australia in the field. The project will provide a high level of training and expertise for Australia-based chemists.Read moreRead less