Milk protein profiling powered by multiplexed single molecule assay. This project aims to develop a novel device, comprising advanced single molecule imaging, microfluidics and immunoassay technologies, for quantification of milk protein variants. Milk quality is central to dairying and variants of proteins in milk affect its market value. No current milk protein detection technologies are readily applied in milk production quality control. This project aims to produce a device that can be used ....Milk protein profiling powered by multiplexed single molecule assay. This project aims to develop a novel device, comprising advanced single molecule imaging, microfluidics and immunoassay technologies, for quantification of milk protein variants. Milk quality is central to dairying and variants of proteins in milk affect its market value. No current milk protein detection technologies are readily applied in milk production quality control. This project aims to produce a device that can be used by milk producers and farms to profile protein variants with high sensitivity in a single test in an hour and screen unwanted protein contamination. The platform also has great potential for detecting other complex and low content analytes. It builds on innovations in nanoparticles and recent industry collaboration.Read moreRead less
Bioinks for the 3D printing of cells made from off-the-shelf components. This project aims to develop a simple method for creating complex, multiple-cell-type three-dimensional (3D) cell cultures for in-vitro cell based assays. Using 3D printing technology, this project will develop a versatile polymer system, made from entirely commercially available components, that gels upon printing and has functionality to assist cells in adhering, growing and migrating. The 3D printing of multiple cell typ ....Bioinks for the 3D printing of cells made from off-the-shelf components. This project aims to develop a simple method for creating complex, multiple-cell-type three-dimensional (3D) cell cultures for in-vitro cell based assays. Using 3D printing technology, this project will develop a versatile polymer system, made from entirely commercially available components, that gels upon printing and has functionality to assist cells in adhering, growing and migrating. The 3D printing of multiple cell types will provide biological scientists with more realistic in-vitro cell assays to those found in-vivo. Applications of the research are in cell biology, studying diseases and developing new drugs.Read moreRead less
Development of an ultrasensitive assay for human prion proteins. The aim of this work is to enable the detection of prion proteins in human blood and other tissues. The assay system to be developed will detect much lower levels of these disease-causing proteins than is possible at present; it will be more rapid and will measure prion protein levels more accurately than existing assays. The outcome of the work is expected to facilitate the production and certification of prion-free blood and bl ....Development of an ultrasensitive assay for human prion proteins. The aim of this work is to enable the detection of prion proteins in human blood and other tissues. The assay system to be developed will detect much lower levels of these disease-causing proteins than is possible at present; it will be more rapid and will measure prion protein levels more accurately than existing assays. The outcome of the work is expected to facilitate the production and certification of prion-free blood and blood products. Prions cause Bovine Spongiform Encaphalopathy and Creutzfeld Jacob Disease and attempts to control of these diseases would be greatly abetted by an optimal test for the disease-causing agent.Read moreRead less
The measurement and prediction of police interviewing performance and the dissemination of good practice through a distributive workplace learning system. This research aims to develop the first ever standardised measures of police interviewers' performance, focusing on interviews about sexual offences. Standardised measures are essential for quality control evaluation, identifying training needs, assigning workload, predicting case outcome and benchmarking organisation capabilities. By improvin ....The measurement and prediction of police interviewing performance and the dissemination of good practice through a distributive workplace learning system. This research aims to develop the first ever standardised measures of police interviewers' performance, focusing on interviews about sexual offences. Standardised measures are essential for quality control evaluation, identifying training needs, assigning workload, predicting case outcome and benchmarking organisation capabilities. By improving the quality of police interviews about sexual offences, this research will improve the reporting, prosecution and conviction rates of sexual offences, which will have a deterrent effect on potential offenders. Further, this research will reduce the stress of witnesses and suspects involved in the legal process and reduce burnout of police interviewers by increasing competency and job satisfaction.Read moreRead less
Solving the problem of detecting small molecules in complex samples: A Label-Free Electrochemical Immuno-biosensor for drugs and pesticides. Biosensors are portable analytical devices which can be used by the general public without specialist training. The proposed research will develop a biosensor for the detection of small molecules such as pesticides, poisons and drugs; a class of analytes where there is currently no viable biosensor technology. The simple to use device will benefit the Aus ....Solving the problem of detecting small molecules in complex samples: A Label-Free Electrochemical Immuno-biosensor for drugs and pesticides. Biosensors are portable analytical devices which can be used by the general public without specialist training. The proposed research will develop a biosensor for the detection of small molecules such as pesticides, poisons and drugs; a class of analytes where there is currently no viable biosensor technology. The simple to use device will benefit the Australian community by providing technology which will allow rapid and inexpensive monitoring of water as well as biomedical diagnosis. The research will also benefit Australia via providing the training of scientists to establish the new generation of Australia's bionanotechnology industry. Read moreRead less
Improved methods for quantitation of acute phase proteins in biological samples. Using monoclonal antibodies and fluorescence polarisation, we aim to develop improved quantitative analytical methods that are superior to the current clinical assays. The initial targets will be C-reactive protein (CRP) and serum amyloid precursor protein (SAP), but the technology should be readily adaptable to other serum proteins. Better assays for CRP and SAP will greatly facilitate improved clinical management ....Improved methods for quantitation of acute phase proteins in biological samples. Using monoclonal antibodies and fluorescence polarisation, we aim to develop improved quantitative analytical methods that are superior to the current clinical assays. The initial targets will be C-reactive protein (CRP) and serum amyloid precursor protein (SAP), but the technology should be readily adaptable to other serum proteins. Better assays for CRP and SAP will greatly facilitate improved clinical management of those at risk of heart attack, the single biggest contributor to healthcare costs in Australia. We further aim to adapt this technology to enable "point-of-care" assays that would help medical practitioners, especially in rural areas, to make informed diagnoses immediately.Read moreRead less
Facilitating the Lifelong Learning Needs of the Mature Age Community through Learning Object Technology. By understanding learner preferences, needs and requirements, it could be possible to provide opportunities in an online learning environment that will improve the quality, variety and relevance of learning for all. There could be particular benefits for mature-age learners. Curtin has begun to explore the benefits of reusable learning objects with current online learning management systems. ....Facilitating the Lifelong Learning Needs of the Mature Age Community through Learning Object Technology. By understanding learner preferences, needs and requirements, it could be possible to provide opportunities in an online learning environment that will improve the quality, variety and relevance of learning for all. There could be particular benefits for mature-age learners. Curtin has begun to explore the benefits of reusable learning objects with current online learning management systems. This project aims to define the use and application of learning object technology and applies a meta-model of pedagogical design to online learning environments. Outcomes will allow the applications of new methodologies for the effective implementation of complex, intelligent learning environments.Read moreRead less
Improving the competency of police officers in conducting investigative interviews of children. The current research program aims to identify factors that promote and sustain competent police interviewing of children. Although 'best-practice' guidelines in investigative interviewing have been developed, these guidelines are under-utilised by police officers in practice. Research is therefore needed to identify barriers to the implementation of these 'best-practice' guidelines and to test interve ....Improving the competency of police officers in conducting investigative interviews of children. The current research program aims to identify factors that promote and sustain competent police interviewing of children. Although 'best-practice' guidelines in investigative interviewing have been developed, these guidelines are under-utilised by police officers in practice. Research is therefore needed to identify barriers to the implementation of these 'best-practice' guidelines and to test interventions designed to improve their uptake. The expected outcome of this project is the development of interventions that will improve the quality of police training in investigative interviewing. This will increase the quality of evidence obtained from children, especially those who are victims of child abuse.Read moreRead less
The impact of post-incident debriefing on psychological wellbeing and recall of events. First response emergency service personnel, such as fire fighters, police officers and paramedics provide an essential service, but as a result of their work are at increased risk of developing Post Traumatic Stress Disorder (PTSD). In an attempt to protect against PTSD many personnel are required to attend group debriefings following exposure to traumatic events. However, there is evidence that these group d ....The impact of post-incident debriefing on psychological wellbeing and recall of events. First response emergency service personnel, such as fire fighters, police officers and paramedics provide an essential service, but as a result of their work are at increased risk of developing Post Traumatic Stress Disorder (PTSD). In an attempt to protect against PTSD many personnel are required to attend group debriefings following exposure to traumatic events. However, there is evidence that these group debriefings may actually increase the risk of PTSD and also permanently distort the participants' memory for the events they witnessed. We will work with NSW Fire Brigade to develop an effective PTSD intervention for emergency service personnel which also preserves the integrity of the participants' memory for critical events.Read moreRead less
Supporting teachers and teaching in flexible and non-traditional schools . This project aims to address a critical gap in knowledge about the experiences and conditions of people who teach in flexible and non-traditional schools in Australia. These schools provide a second chance at education for young people with challenging behaviours and/or learning problems. This project expects to generate new knowledge about the experiences and needs of these teachers, using a combination of in-depth resea ....Supporting teachers and teaching in flexible and non-traditional schools . This project aims to address a critical gap in knowledge about the experiences and conditions of people who teach in flexible and non-traditional schools in Australia. These schools provide a second chance at education for young people with challenging behaviours and/or learning problems. This project expects to generate new knowledge about the experiences and needs of these teachers, using a combination of in-depth research methods. Expected outcomes include detailed understanding of support needs for this workforce. This will significantly benefit teachers, sponsors and principals through recommendations on best practice management of this important work, along with evidence-based training artefacts for staff recruitment and retention.
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