Comprehensive characterisation of DNA demethylation pathways in vivo. This project aims to provide a better understanding of the roles that DNA methylation plays during embryonic development. DNA methylation is a major regulatory mark present in vertebrate genomes. It is well established that the genomic patterns of DNA methylation are being actively remodelled during vertebrate embryogenesis. Nevertheless, it remains unclear how these events impact gene regulation and embryonic development itse ....Comprehensive characterisation of DNA demethylation pathways in vivo. This project aims to provide a better understanding of the roles that DNA methylation plays during embryonic development. DNA methylation is a major regulatory mark present in vertebrate genomes. It is well established that the genomic patterns of DNA methylation are being actively remodelled during vertebrate embryogenesis. Nevertheless, it remains unclear how these events impact gene regulation and embryonic development itself. This project expects to unravel the functional contributions of DNA methylation to vertebrate embryogenesis by using latest cutting-edge genomics techniques. The project will be carried out on the highly tractable zebrafish model system which allows for easy genetic manipulation of the desired sequences. This project aims to provide a better understanding of embryonic development of vertebrates, including humans.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100056
Funder
Australian Research Council
Funding Amount
$621,198.00
Summary
High-frequency ultrasound and photoacoustic imaging for Western Australia. This project aims to obtain a small animal, high-frequency ultrasound and photoacoustic imaging instrument, to be placed in the University of Western Australia's Centre for Microscopy, Characterisation and Analysis. As a node of the National Imaging Facility, this infrastructure will result in enhanced capacity for fundamental, interdisciplinary, biological, and bionanotechnology research in Western Australia, and enable ....High-frequency ultrasound and photoacoustic imaging for Western Australia. This project aims to obtain a small animal, high-frequency ultrasound and photoacoustic imaging instrument, to be placed in the University of Western Australia's Centre for Microscopy, Characterisation and Analysis. As a node of the National Imaging Facility, this infrastructure will result in enhanced capacity for fundamental, interdisciplinary, biological, and bionanotechnology research in Western Australia, and enable pursuit of projects previously only possible either interstate or internationally. New capacity in small animal in-vivo imaging will generate knowledge in biology, feeding into such areas as species conservation and reproductive health, and intellectual property and commercial opportunity in areas such as medical imaging and theranostics.Read moreRead less
Fleshing out the fossil record: using organically preserved soft tissues and bone to explore the evolution of unique vertebrate characters. This study integrates developmental, molecular and morphological data in both fossil and living species to provide insights into the evolutionary mechanisms which formed the musculo/skeletal system. Uncovering these evolutionary pathways has the potential to describe mechanisms common to all vertebrate and informs us about our own evolution.
Discovery Early Career Researcher Award - Grant ID: DE140101962
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Functional epigenomics interrogation of DNA methylation dynamics during vertebrate development and evolution. DNA methylation (mC) is an epigenetic signal essential for the maintenance of correct gene expression patterns. To investigate the causal relationships between mC and transcription during vertebrate embryonic development and evolution, this project will perform high-resolution mC profiling at different stages of teleost, amphibian and mammalian development. Highly conserved and syntenic, ....Functional epigenomics interrogation of DNA methylation dynamics during vertebrate development and evolution. DNA methylation (mC) is an epigenetic signal essential for the maintenance of correct gene expression patterns. To investigate the causal relationships between mC and transcription during vertebrate embryonic development and evolution, this project will perform high-resolution mC profiling at different stages of teleost, amphibian and mammalian development. Highly conserved and syntenic, methylated sequences will then be used as baits in proteomics screens to identify novel 5mC 'readers'. The generation of genomic profiles of mC 'readers' and their integration with developmental mC maps will reveal transient epigenome dynamics during vertebrate embryogenesis and provide new insights into the conservation of these crucial developmental mechanisms.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100019
Funder
Australian Research Council
Funding Amount
$4,583,816.00
Summary
ARC Training Centre for Optimal Ageing. The ARC Training Centre for Optimal Ageing aims to address issues identified by older adults as essential for quality of life. With our industry partners, we aim to train the next generation of researchers to understand, detect and improve psychosocial factors that support mental activity, physical health and social connectedness, and embrace advances in artificial intelligence, digital-enriched environments and adaptive workplaces to deliver effective dig ....ARC Training Centre for Optimal Ageing. The ARC Training Centre for Optimal Ageing aims to address issues identified by older adults as essential for quality of life. With our industry partners, we aim to train the next generation of researchers to understand, detect and improve psychosocial factors that support mental activity, physical health and social connectedness, and embrace advances in artificial intelligence, digital-enriched environments and adaptive workplaces to deliver effective digital solutions. By developing new capacity and capability to drive the digital transformation of industries supporting our ageing population, our Centre seeks to deliver economic and social benefits that enable Australians to live enriched, healthy and independent lives as they age.Read moreRead less