Neurobiology Of Childhood Speech Disorders: Improving Detection, Diagnosis And Clinical Care
Funder
National Health and Medical Research Council
Funding Amount
$994,575.00
Summary
One in 20 children have a speech disorder at school entry, with lifelong deficits in psychosocial, academic and employment outcomes. Little is known about the aetiology of speech disorders, preventing targeted care. We combine expertise in speech pathology, gene discovery and brain imaging, to advance knowledge on gene and brain contributions to speech disorder. We will have direct impacts on clinical care including detection, diagnosis and counselling, optimising outcomes for affected children.
Attentional mechanisms in the relationship between sleep disruption and academic outcomes in Australian school children. This project will assess the impact of sleep problems on attention and academic performance in primary school children. The project will investigate typically developing children and children with developmental disorders over 18 months. The research will advance knowledge of the interplay between sleep, attention and learning across development.
Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.
Morphological development of the kidney – a paradigm for organogenesis. This project aims to shed new light on how the kidney develops, how normal adult function is established and how congenital kidney malformations occur. It aims to investigate a mathematical pattern that has been discovered in the program of branching morphogenesis which dictates kidney development. By combining cutting-edge genetic approaches, morphological analysis and mathematical modelling, this project plans to explore h ....Morphological development of the kidney – a paradigm for organogenesis. This project aims to shed new light on how the kidney develops, how normal adult function is established and how congenital kidney malformations occur. It aims to investigate a mathematical pattern that has been discovered in the program of branching morphogenesis which dictates kidney development. By combining cutting-edge genetic approaches, morphological analysis and mathematical modelling, this project plans to explore how this pattern is established, how it dictates kidney development and whether it constitutes an ancient mechanism central to organ formation. Project outcomes may improve understanding of fundamental developmental processes and developmental disease and variation. Project findings may also be important for understanding the development of other organ systems.Read moreRead less
The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations ....The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations will predict the development of alcohol/tobacco use and misuse, after accounting for viable alternative explanations of the association. Understanding the role that memory associations have in the development of alcohol/tobacco use should inform prevention programs for at-risk adolescents.Read moreRead less
The developmental origins of tool innovation. Solving new problems by making new tools, or using old tools in new ways, is a hallmark of our species. Theoretical and experimental enquiry into children’s developing socio-cognitive abilities conflicts with recent research suggesting young children are poor tool innovators. This project will be the first to confidently disambiguate our knowledge about whether children are capable of tool innovation by systematically investigating their abilities us ....The developmental origins of tool innovation. Solving new problems by making new tools, or using old tools in new ways, is a hallmark of our species. Theoretical and experimental enquiry into children’s developing socio-cognitive abilities conflicts with recent research suggesting young children are poor tool innovators. This project will be the first to confidently disambiguate our knowledge about whether children are capable of tool innovation by systematically investigating their abilities using a new comprehensive battery of tasks, novel test conditions and the integration of data from industrialised and indigenous communities in Australia and Southern Africa. This research will provide the broadest insights yet into the development of a key feature of the human condition.Read moreRead less
Over-imitation, trial-and-error learning and the inter-generational transmission of information. This project will investigate how cultural knowledge is developed and transmitted from one generation to the next through imitation and trial-and-error learning. Testing children from industrialised and indigenous communities will provide unique data, generate new knowledge and provide a foundation for developing new educational approaches.
Do theory of mind delays explain children's social problems? Theory of mind—our capacity to understand what other people think and feel—grows significantly in the preschool and early school years. This is recognised as a crucial period for social development yet 30 years of research has not yet answered these basic questions: Do children with relatively advanced theories of mind also excel at navigating the everyday world of friendship and peer group dynamics at school? And conversely, do develo ....Do theory of mind delays explain children's social problems? Theory of mind—our capacity to understand what other people think and feel—grows significantly in the preschool and early school years. This is recognised as a crucial period for social development yet 30 years of research has not yet answered these basic questions: Do children with relatively advanced theories of mind also excel at navigating the everyday world of friendship and peer group dynamics at school? And conversely, do developmental delays in acquiring a theory of mind explain some of the peer problems that children with autism or deafness face? The proposed longitudinal project aims to be the first to supply a comprehensive and causally convincing answer to these core questions.Read moreRead less
Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to de ....Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to develop services and interventions aimed at preventing young people from becoming enmeshed in the criminal justice system.Read moreRead less
A RCT of an education reengagement program for at-risk youth. A RCT of an education reengagement program for at-risk youth. This project aims to determine the best and most cost-effective way to help 12–15 year olds re-engage with school when they become at-risk for dropping out, by conducting a gold-standard randomized-control trial. 20% of Australians fail to attain a Year 12 or equivalent certificate, often for preventable reasons. Dropouts are more likely to be unemployed, have psychological ....A RCT of an education reengagement program for at-risk youth. A RCT of an education reengagement program for at-risk youth. This project aims to determine the best and most cost-effective way to help 12–15 year olds re-engage with school when they become at-risk for dropping out, by conducting a gold-standard randomized-control trial. 20% of Australians fail to attain a Year 12 or equivalent certificate, often for preventable reasons. Dropouts are more likely to be unemployed, have psychological, social, and health problems, and end up in prison. This project could influence implementation of programmes and policy related to youth dropout, promote youth economic, social and physical wellbeing, and decrease their chance of committing crimes and becoming a social burden.Read moreRead less