Hedgehog Signalling In Limb And Craniofacial Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$494,544.00
Summary
Anomalies of the face and limbs are amongst the most common features of human birth defects, and their frequent association suggests that the same genes are involved in governing the development of the limbs and face during embryogenesis. We have used a genomics-based approach to identify genes involved in limb development based on their alteration in a mouse model which develops extra fingers and toes. Defects in this mouse result from changes in Gli3, a gene which is known to be important in b ....Anomalies of the face and limbs are amongst the most common features of human birth defects, and their frequent association suggests that the same genes are involved in governing the development of the limbs and face during embryogenesis. We have used a genomics-based approach to identify genes involved in limb development based on their alteration in a mouse model which develops extra fingers and toes. Defects in this mouse result from changes in Gli3, a gene which is known to be important in both limb and face development. Based on the organs in which our genes of interest are active, we believe that they will also play key roles in embryonic development of the limbs, face and other organs. We now plan to investigate the regulation of a subset of these genes based on analysis in mouse models of limb and face development. In addition, we have chosen to further analyse the function of a completely novel gene we have identified which our preliminary studies suggest may play a role in the normal development of the lip and palate. These studies have the potential to shed light on the processes governing how organs develop, as well as on the molecular basis of common birth defects such as polydactyly (extra fingers and toes) and cleft palate.Read moreRead less
Functional Nano-cement Scaffolds For The Treatment Of Osteoporotic Bone Defects
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Osteoporosis affects 1.2 million Australians and will cost $33.6 billion by 2022. This study aims to develop a novel nano-cement platform for custom-designed bone repair in osteoporosis, by using purpose-designed nanomaterials and advanced 3D printing technique. The research findings will lead to the development of a new bone repair strategy, expand knowledge on both biomaterials engineering and osteoporosis treatment, and improve the quality of life of Australians.
Neurobiology Of Childhood Speech Disorders: Improving Detection, Diagnosis And Clinical Care
Funder
National Health and Medical Research Council
Funding Amount
$994,575.00
Summary
One in 20 children have a speech disorder at school entry, with lifelong deficits in psychosocial, academic and employment outcomes. Little is known about the aetiology of speech disorders, preventing targeted care. We combine expertise in speech pathology, gene discovery and brain imaging, to advance knowledge on gene and brain contributions to speech disorder. We will have direct impacts on clinical care including detection, diagnosis and counselling, optimising outcomes for affected children.
Attentional mechanisms in the relationship between sleep disruption and academic outcomes in Australian school children. This project will assess the impact of sleep problems on attention and academic performance in primary school children. The project will investigate typically developing children and children with developmental disorders over 18 months. The research will advance knowledge of the interplay between sleep, attention and learning across development.
Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.
Morphological development of the kidney – a paradigm for organogenesis. This project aims to shed new light on how the kidney develops, how normal adult function is established and how congenital kidney malformations occur. It aims to investigate a mathematical pattern that has been discovered in the program of branching morphogenesis which dictates kidney development. By combining cutting-edge genetic approaches, morphological analysis and mathematical modelling, this project plans to explore h ....Morphological development of the kidney – a paradigm for organogenesis. This project aims to shed new light on how the kidney develops, how normal adult function is established and how congenital kidney malformations occur. It aims to investigate a mathematical pattern that has been discovered in the program of branching morphogenesis which dictates kidney development. By combining cutting-edge genetic approaches, morphological analysis and mathematical modelling, this project plans to explore how this pattern is established, how it dictates kidney development and whether it constitutes an ancient mechanism central to organ formation. Project outcomes may improve understanding of fundamental developmental processes and developmental disease and variation. Project findings may also be important for understanding the development of other organ systems.Read moreRead less
The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations ....The initiation, development, and maintenance of alcohol/tobacco use in adolescents: The role of associative memory. Alcohol abuse and tobacco misuse are common in Australian adolescents and its long-term health consequences are well established. Models of drug-related memory association predict drug use in adults. However, memory association models have not been applied to smoking behaviour, or to understanding adolescent alcohol/tobacco use over time. It is expected that memory associations will predict the development of alcohol/tobacco use and misuse, after accounting for viable alternative explanations of the association. Understanding the role that memory associations have in the development of alcohol/tobacco use should inform prevention programs for at-risk adolescents.Read moreRead less
The developmental origins of tool innovation. Solving new problems by making new tools, or using old tools in new ways, is a hallmark of our species. Theoretical and experimental enquiry into children’s developing socio-cognitive abilities conflicts with recent research suggesting young children are poor tool innovators. This project will be the first to confidently disambiguate our knowledge about whether children are capable of tool innovation by systematically investigating their abilities us ....The developmental origins of tool innovation. Solving new problems by making new tools, or using old tools in new ways, is a hallmark of our species. Theoretical and experimental enquiry into children’s developing socio-cognitive abilities conflicts with recent research suggesting young children are poor tool innovators. This project will be the first to confidently disambiguate our knowledge about whether children are capable of tool innovation by systematically investigating their abilities using a new comprehensive battery of tasks, novel test conditions and the integration of data from industrialised and indigenous communities in Australia and Southern Africa. This research will provide the broadest insights yet into the development of a key feature of the human condition.Read moreRead less
Over-imitation, trial-and-error learning and the inter-generational transmission of information. This project will investigate how cultural knowledge is developed and transmitted from one generation to the next through imitation and trial-and-error learning. Testing children from industrialised and indigenous communities will provide unique data, generate new knowledge and provide a foundation for developing new educational approaches.
Do theory of mind delays explain children's social problems? Theory of mind—our capacity to understand what other people think and feel—grows significantly in the preschool and early school years. This is recognised as a crucial period for social development yet 30 years of research has not yet answered these basic questions: Do children with relatively advanced theories of mind also excel at navigating the everyday world of friendship and peer group dynamics at school? And conversely, do develo ....Do theory of mind delays explain children's social problems? Theory of mind—our capacity to understand what other people think and feel—grows significantly in the preschool and early school years. This is recognised as a crucial period for social development yet 30 years of research has not yet answered these basic questions: Do children with relatively advanced theories of mind also excel at navigating the everyday world of friendship and peer group dynamics at school? And conversely, do developmental delays in acquiring a theory of mind explain some of the peer problems that children with autism or deafness face? The proposed longitudinal project aims to be the first to supply a comprehensive and causally convincing answer to these core questions.Read moreRead less