Brain development during adolescence and the emergence of depression: A longitudinal MRI study. Traditionally mental health services have focused on established disorders. Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the inability to predict who is likely to go on to develop serious mental disorder. This study will provide critical information for und ....Brain development during adolescence and the emergence of depression: A longitudinal MRI study. Traditionally mental health services have focused on established disorders. Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the inability to predict who is likely to go on to develop serious mental disorder. This study will provide critical information for understanding the risk processes that are operating during the critical phase of early adolescence, and will therefore make a fundamental contribution to our understanding of who, and what, to target in early intervention and prevention strategies.Read moreRead less
Charting the prevalence, time course and social-cognitive correlates of neonatal imitation. Imitation is something that we do naturally and often. However, because the necessary research has not been done, it remains controversial whether or not humans can imitate from birth and what role this may play for later developments. The proposed research aims to settle these issues through a comprehensive, longitudinal study of infant imitation and its relation to later-developing social skills. A trai ....Charting the prevalence, time course and social-cognitive correlates of neonatal imitation. Imitation is something that we do naturally and often. However, because the necessary research has not been done, it remains controversial whether or not humans can imitate from birth and what role this may play for later developments. The proposed research aims to settle these issues through a comprehensive, longitudinal study of infant imitation and its relation to later-developing social skills. A training condition will examine the viability of potential early interventions aimed at promoting social responding in infants and toddlers. This project will generate new knowledge about the development of early social skills and provide the foundation for new programs to enhance social development in typical and at-risk infants. Read moreRead less
Linking arterial, brain and cognitive integrity in healthy older adults. This project aims to demonstrate that engaging the brain’s prefrontal cortex, an area that is highly sensitive to ageing, can improve the function of arteries that supply blood to this brain region. Using an innovative optical imaging methodology that maps the brain’s regional arterial health, it aims to generate new knowledge about the link between this arterial system and the progressive decline in cognitive control abili ....Linking arterial, brain and cognitive integrity in healthy older adults. This project aims to demonstrate that engaging the brain’s prefrontal cortex, an area that is highly sensitive to ageing, can improve the function of arteries that supply blood to this brain region. Using an innovative optical imaging methodology that maps the brain’s regional arterial health, it aims to generate new knowledge about the link between this arterial system and the progressive decline in cognitive control ability and in prefrontal cortex structure and function in healthy older adults. This interdisciplinary, international collaboration aims to put Australia at the forefront of brain optical imaging methods that may have significant benefits by informing approaches to promote and maintain healthy brain and cognition in old age.Read moreRead less
The elusive engram: What can infantile amnesia tell us about memory? Revealing the 'engram' is one of the greatest challenges neuroscience has faced. Substantial advances have been made in elucidating the mechanisms underlying memories that last for a few hours or days but much less is known about the cellular and molecular processes that mediate memories across remote periods of time. An underutilised approach to this problem is to study forgetting. The infant rat is an ideal model as they typi ....The elusive engram: What can infantile amnesia tell us about memory? Revealing the 'engram' is one of the greatest challenges neuroscience has faced. Substantial advances have been made in elucidating the mechanisms underlying memories that last for a few hours or days but much less is known about the cellular and molecular processes that mediate memories across remote periods of time. An underutilised approach to this problem is to study forgetting. The infant rat is an ideal model as they typically display good memory for a day or two but forget after a week or more. That is, they exhibit a specific impairment in the maintenance of remote memories. This project aims to determine the molecular/cellular processes underlying infantile amnesia and is expected to provide unique insights into memory processes in general.Read moreRead less
Effects of early life trauma on fear memory and fear extinction in rats. This project aims to increase our understanding of how early life stress affects fear regulation across development. The results will provide unique insights into normal developmental changes in fear regulation as well as abnormal developmental changes in these processes in those exposed to early life stress.
The future of childhood anxiety treatment: translating cognitive-neuroscience insights into clinical practice. The newest adult anxiety treatments use computer-based tasks that provide practice in overcoming maladaptive thinking patterns. This project is among the first to test this approach with children by developing a simple intervention that can be done at home. This new treatment will significantly reduce the burden of disease in Australia.
The role of early testosterone and brain laterality in language development. The aim of the project is to provide key insights into how foetal hormone exposure and early brain growth support child language. The specialisation of the left cerebral hemisphere for language function is considered critical to supporting the complexity of human language. There is evidence of sex differences in patterns of brain specialisation, which has led to popular but unsubstantiated hypotheses linking prenatal te ....The role of early testosterone and brain laterality in language development. The aim of the project is to provide key insights into how foetal hormone exposure and early brain growth support child language. The specialisation of the left cerebral hemisphere for language function is considered critical to supporting the complexity of human language. There is evidence of sex differences in patterns of brain specialisation, which has led to popular but unsubstantiated hypotheses linking prenatal testosterone and language development. The project aims to explore this by using innovative neuroimaging, endocrine and genetic techniques to track neurodevelopment longitudinally from prenatal life to three years of age. An important aspect of the project is the anticipated refinement of innovative methods for measuring early human development.Read moreRead less
Uncovering the mechanisms of early memory development: A new approach using eye tracking. This research represents a theoretical and methodological advance in developmental science. In combining behavioural measures of infant memory with novel eye-tracking methods and electrophysiology, this research will significantly advance our knowledge about the nature of infant memory representation and our understanding of the mechanisms of early memory development. The research will further solidify Aust ....Uncovering the mechanisms of early memory development: A new approach using eye tracking. This research represents a theoretical and methodological advance in developmental science. In combining behavioural measures of infant memory with novel eye-tracking methods and electrophysiology, this research will significantly advance our knowledge about the nature of infant memory representation and our understanding of the mechanisms of early memory development. The research will further solidify Australia's reputation as an innovative leader in the rapidly growing field of developmental cognitive neuroscience. Third, the interdisciplinary nature of this project will provide internationally-competitive research training opportunities for Australian students.Read moreRead less
Glucose facilitation of cognitive function: Effects of effort, age and glucose control. Age-related decline in mental capacity contributes to the economic (estimated at over 2 trillion AUD by 2050), social and human costs of an increasingly older Australian population. The studies in this program aim to understand the role of poor control of blood glucose in age-related cognitive deficits. The role of individual differences in biological (hormonal responses) and psychological (stress and appetit ....Glucose facilitation of cognitive function: Effects of effort, age and glucose control. Age-related decline in mental capacity contributes to the economic (estimated at over 2 trillion AUD by 2050), social and human costs of an increasingly older Australian population. The studies in this program aim to understand the role of poor control of blood glucose in age-related cognitive deficits. The role of individual differences in biological (hormonal responses) and psychological (stress and appetite) factors will also be assessed. A better understanding of the nature of age-related cognitive decline as it relates to biological processes such as blood glucose control will help to develop tangible strategies to combat age-related cognitive decline and dementia (which has been described as Type 3 diabetes).Read moreRead less
Modelling trajectories of cognitive control in adolescents and young adults. This project aims to develop an innovative framework that models behaviour, brain function and brain structure to characterise developmental trajectories of cognitive control in typically-developing young people, and to test the model’s ability to predict psychosocial outcomes. Cognitive control processes are supported by complex frontal brain networks that develop well into adulthood. Poor cognitive control is linked t ....Modelling trajectories of cognitive control in adolescents and young adults. This project aims to develop an innovative framework that models behaviour, brain function and brain structure to characterise developmental trajectories of cognitive control in typically-developing young people, and to test the model’s ability to predict psychosocial outcomes. Cognitive control processes are supported by complex frontal brain networks that develop well into adulthood. Poor cognitive control is linked to negative psychosocial outcomes (e.g. substance use, high-risk behaviours). This work is expected to inform evidence-based programmes that identify young people at risk and develop targeted training strategies to improve psychosocial outcomes.Read moreRead less