Cognitive, behavioural and educational outcomes of fetal antiepileptic drug exposure. The study falls within the National Research Priority of Promoting and Maintaining Good Health, in particular the Priority Goal - A Healthy Start to Life. The research will yield information crucial to our understanding of the effects of fetal AED exposure on cognitive and behavioural development in the significant number of affected Australian children born each year. It will enhance the nation's ability to de ....Cognitive, behavioural and educational outcomes of fetal antiepileptic drug exposure. The study falls within the National Research Priority of Promoting and Maintaining Good Health, in particular the Priority Goal - A Healthy Start to Life. The research will yield information crucial to our understanding of the effects of fetal AED exposure on cognitive and behavioural development in the significant number of affected Australian children born each year. It will enhance the nation's ability to develop strategies for prevention, surveillance and remediation of adverse outcomes in early childhood, thus supporting the Government's National Agenda for Early Childhood initiative. As a consequence educational assistance can be targeted for those children likely to experience difficulties. Read moreRead less
The role of preferred brain states in perceptual and cognitive processing: New insights into brain dynamics. New insights into brain dynamics will improve our understanding of both normal and atypical functioning. Extending previous work on normals will confirm how innovative Australian approaches can lead the research agenda in basic neuroscience, at the psychology-physiology interface. Testing in AD/HD and elderly populations will clarify dysfunctional brain mechanisms underlying AD/HD, and th ....The role of preferred brain states in perceptual and cognitive processing: New insights into brain dynamics. New insights into brain dynamics will improve our understanding of both normal and atypical functioning. Extending previous work on normals will confirm how innovative Australian approaches can lead the research agenda in basic neuroscience, at the psychology-physiology interface. Testing in AD/HD and elderly populations will clarify dysfunctional brain mechanisms underlying AD/HD, and the cognitive losses in elderly populations (exacerbated by dementia). These results may lead to better diagnosis, treatment, and community understanding of these groups. Also, publications on these target groups will demonstrate internationally the widespread utility of this approach, encouraging further novel applications of basic neuroscience in health.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239381
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
Sleep-wake problems in people without primary sleep disorders. Portable sleep recording equipment will enable research to be conducted on sleep wake issues in people under a variety of conditions; such as those arising from substance intake (alcohol, nicotine, caffeine), life stage (menopause, elderly), developmental disorders (intellectual disability, autism, fragile X, ADHD) and other syndromes (chronic pain, depression). This is of particular significance given that sleep problems can cause ....Sleep-wake problems in people without primary sleep disorders. Portable sleep recording equipment will enable research to be conducted on sleep wake issues in people under a variety of conditions; such as those arising from substance intake (alcohol, nicotine, caffeine), life stage (menopause, elderly), developmental disorders (intellectual disability, autism, fragile X, ADHD) and other syndromes (chronic pain, depression). This is of particular significance given that sleep problems can cause daytime sleepiness, fatigue, poor vigilance, lack of attention, negative mood and poor memory. The establishment of this cross-institutional collaborative facility will permit ongoing scientific investigation of such sleep-wake issues with beneficial health and safety implications for community.Read moreRead less
The cognitive neuroscience of executive control: behavioural, physiological and genetic mechanisms. How genes influence our human abilities to think, reason and control behaviour has puzzled scientists for decades. The human genome project has allowed us to ask how individual genes influence these capacities. Understanding the genetics of these abilities provides a solid platform from which to launch gene discovery projects in clinical disorders where these abilities are compromised. The curr ....The cognitive neuroscience of executive control: behavioural, physiological and genetic mechanisms. How genes influence our human abilities to think, reason and control behaviour has puzzled scientists for decades. The human genome project has allowed us to ask how individual genes influence these capacities. Understanding the genetics of these abilities provides a solid platform from which to launch gene discovery projects in clinical disorders where these abilities are compromised. The current project is directly relevant to the genetics of mental disorders, such as attention deficit hyperactivity (ADHD), that place a large burden, both financially and emotionally, on our society. Understanding the genes and biological pathways that increase risk for mental disorders will ultimately lead to improved treatments for these conditions.Read moreRead less
Continuity and change in the development of young children with autism. Autism is a severe condition affecting social interaction, communication, behaviour and interests. Parents of children with autism experience high levels of stress associated with the burden of caring. There is a high societal cost associated with the care of people with autism. Research shows outcome in autism is poor, but that early intervention may improve outcome. This project will identify specific early precursors of a ....Continuity and change in the development of young children with autism. Autism is a severe condition affecting social interaction, communication, behaviour and interests. Parents of children with autism experience high levels of stress associated with the burden of caring. There is a high societal cost associated with the care of people with autism. Research shows outcome in autism is poor, but that early intervention may improve outcome. This project will identify specific early precursors of autism which predict outcome. This will allow the development of targeted intervention to give children the best possible start in life and improve longterm outcome. Improvement to the outcome of people with autism will considerably reduce parental and family burden and cost to the community.Read moreRead less
Validation of a New Conceptual Model of ADHD based on Underlying Central Nervous System Dysfunction. ADHD is a debilitating problem that affects 5% of children and approximately half as many adults. ADHD causes substantial problems at school and if untreated, predisposes the individual to increased drug and alcohol use, marital breakdown, criminal prosecution and psychiatric problems in later life. One problem is that we do not fully understand what are the causes of the disorder. This project w ....Validation of a New Conceptual Model of ADHD based on Underlying Central Nervous System Dysfunction. ADHD is a debilitating problem that affects 5% of children and approximately half as many adults. ADHD causes substantial problems at school and if untreated, predisposes the individual to increased drug and alcohol use, marital breakdown, criminal prosecution and psychiatric problems in later life. One problem is that we do not fully understand what are the causes of the disorder. This project will test the validity of several models of brain dysfunction in ADHD which have been influential in the literature, but poorly tested. Through better understanding of the basic underlying problems, more effective intervention can be developed.Read moreRead less
Improving the quality of life of children born very premature. This research program is in line with the national research priority to promote good health and well being, and more specifically to provide a healthy start to life for high-risk infants. This research program is attempting to improve the quality of life of infants born very preterm by improving our understanding of the nature of the problems faced by these high-risk children. This knowledge will inform future preventative care and ....Improving the quality of life of children born very premature. This research program is in line with the national research priority to promote good health and well being, and more specifically to provide a healthy start to life for high-risk infants. This research program is attempting to improve the quality of life of infants born very preterm by improving our understanding of the nature of the problems faced by these high-risk children. This knowledge will inform future preventative care and early intervention strategies. More directly, this research program incorporates a series of randomised controlled trials which are all attempting to improve the health and well being of these vulnerable infants.Read moreRead less
Development of Central Nervous System Functioning in AD/HD: a Longitudinal Study. Attention-Deficit/Hyperactivity Disorder (AD/HD) is a debilitating problem affecting 5% of children. AD/HD causes substantial school problems and predisposes the child to drug and alcohol abuse, marital breakdown, criminal prosecution and psychiatric problems in later life. At present we know very little about the underlying causes of the behavioural changes seen in this disorder. This project will clarify the matu ....Development of Central Nervous System Functioning in AD/HD: a Longitudinal Study. Attention-Deficit/Hyperactivity Disorder (AD/HD) is a debilitating problem affecting 5% of children. AD/HD causes substantial school problems and predisposes the child to drug and alcohol abuse, marital breakdown, criminal prosecution and psychiatric problems in later life. At present we know very little about the underlying causes of the behavioural changes seen in this disorder. This project will clarify the maturational abnormalities in brain function that occur from childhood through to adulthood in this disorder. Better understanding of the normal developmental paths of this disorder will have major clinical benefits as it will allow the development of more optimal treatment plans for these children.Read moreRead less
Behaviour and emotional problems in young children with developmental delay. This research will provide health professionals, researchers and service providers with a reliable and valid measure to assess behaviour in young children with developmental delay. This will be the first instrument of its kind worldwide. The study will provide the largest and most comprehensive survey of behaviour and emotional problems in young children with developmental delay internationally to date. It will provide ....Behaviour and emotional problems in young children with developmental delay. This research will provide health professionals, researchers and service providers with a reliable and valid measure to assess behaviour in young children with developmental delay. This will be the first instrument of its kind worldwide. The study will provide the largest and most comprehensive survey of behaviour and emotional problems in young children with developmental delay internationally to date. It will provide information on the types of treatment that are needed for these children and what support is needed for their families. The outcomes of this study have the potential to promote the best possible start in life and long term mental health of this group of at risk and disadvantaged young Australians.Read moreRead less
Resilience and vulnerability in children with seriously ill siblings. Families of seriously ill children face heavy emotional and practical stresses. Behavioural, emotional and social problems are potential outcomes for the well children in the family, with a range of personal and familial factors likely mediators. The aim of this research is to assess factors associated with resilience and vulnerability among siblings of seriously ill children with a view to informing the work of the Carenet or ....Resilience and vulnerability in children with seriously ill siblings. Families of seriously ill children face heavy emotional and practical stresses. Behavioural, emotional and social problems are potential outcomes for the well children in the family, with a range of personal and familial factors likely mediators. The aim of this research is to assess factors associated with resilience and vulnerability among siblings of seriously ill children with a view to informing the work of the Carenet organization. A survey of parents and well siblings of ill children, plus interviews with target families, will be conducted. Proposed outcomes include a scholarly thesis and a practical booklet of coping resources for families.Read moreRead less