Social Impact and Connection Outcomes Associated with Community Sport. Outcomes of social connection from community sport are widely touted and supported to exist. However, we know little about how social infrastructure actually delivers these benefits. It is difficult to understand and develop practices that organisations can use to maximise the outcomes of sport participation. This research aims to investigate how social infrastructure delivers social connection outcomes associated with commun ....Social Impact and Connection Outcomes Associated with Community Sport. Outcomes of social connection from community sport are widely touted and supported to exist. However, we know little about how social infrastructure actually delivers these benefits. It is difficult to understand and develop practices that organisations can use to maximise the outcomes of sport participation. This research aims to investigate how social infrastructure delivers social connection outcomes associated with community sport. Expected outcomes include novel practice based tools and guidance for community groups to enhance social connection outcomes and new understanding about the role of social infrastructure in enhancing community connection. Improved social connection is expected to improve resilience and community wellbeing.
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Novel therapies to limit renal fibrosis in diverse models of renal disease. Kidney failure is a devastating health, social and financial outcome for the individual, their employer, family and the broader society, This project will carefully dissect mechanisms underpinning the scarring in the kidney that predisposes to kidney failure and will investigate novel therapies to prevent kidney damage.
Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and aga ....Improving determinants of Australian sports talent identification and development: a multi-disciplinary approach. Sport is important to many Australians. Our sport successes enhance our national identity, generate community pride and attract mega sport events. Currently our sport talent identification and development (TID) systems have been surpassed by our international rivals who borrowed from and improved our knowledge. This project will help regain Australia's international advantage and again make Australian TID the international benchmark. Results will highlight the role of TID practices in improving recreational participation and maximising, attracting, developing and retaining sport talent. This will result in improved use of sports limited TID funding by providing greater understanding of factors that influence elite selection and sport development.Read moreRead less
Mental Toughness: What Makes a Champion? "Mental toughness" is claimed to be what makes champion athletes; separates winners from losers and those who buckle under pressure. Despite widespread use in sport (business, military, etc.) there exist no well-validated mental toughness measures. In collaboration with Australian Institute of Sport and Westfields Sports High School, we will develop a multidimensional, hierarchical measure of mental toughness, test it across gender, age, and different spo ....Mental Toughness: What Makes a Champion? "Mental toughness" is claimed to be what makes champion athletes; separates winners from losers and those who buckle under pressure. Despite widespread use in sport (business, military, etc.) there exist no well-validated mental toughness measures. In collaboration with Australian Institute of Sport and Westfields Sports High School, we will develop a multidimensional, hierarchical measure of mental toughness, test it across gender, age, and different sports, validate it in relation to relevant outcomes, and evaluate its growth/development in athletes varying in age and sporting development. Potential benefits include improved talent identification, counselling, self-concept, coping strategies, coaching, benchmarking, tracking, and athletic performance.Read moreRead less
New strategies for characterising and monitoring protein-surface interactions: application to a biosensor for diabetic’s blood glucose regime effectiveness. This project aims to develop an antibody based biosensor for the detection of glycosylated haemoglobin (HbA1c) which serves as a marker of the effectiveness of a diabetic’s blood glucose treatment regime. Monitoring HbA1c is important as many of the long term health effects of diabetes are a consequence of high blood glucose levels. The si ....New strategies for characterising and monitoring protein-surface interactions: application to a biosensor for diabetic’s blood glucose regime effectiveness. This project aims to develop an antibody based biosensor for the detection of glycosylated haemoglobin (HbA1c) which serves as a marker of the effectiveness of a diabetic’s blood glucose treatment regime. Monitoring HbA1c is important as many of the long term health effects of diabetes are a consequence of high blood glucose levels. The simple to use technology will be a general detection strategy for proteins and hence will be applicable for the detection of a wide range of diseases and biomarkers. The research will also benefit Australia by training the new generation of scientists for Australia's biomedical diagnostics industry.Read moreRead less
Establishing evidence for the functional properties of a whole grain in weight management. The successful development of functional foods relies on communicating proven effects. This project aims to prove that the food containing the satiety properties of a whole grain (OG) may help in weight management. We will conduct basic research investigating the link between consumption of OG-containing foods and the regulatory mechanisms of satiety, and test whether the satiety properties can be used to ....Establishing evidence for the functional properties of a whole grain in weight management. The successful development of functional foods relies on communicating proven effects. This project aims to prove that the food containing the satiety properties of a whole grain (OG) may help in weight management. We will conduct basic research investigating the link between consumption of OG-containing foods and the regulatory mechanisms of satiety, and test whether the satiety properties can be used to prevent, reduce and correct body weight gain in the early, middle and late stages of obesity. We will then apply this understanding in a human trial of mildly and long term overweight subjects, to aid the formulation of statements on the potential health benefits from consuming OG.Read moreRead less
Development of natural herbal medicines for managing metabolic syndrome in order to prevent type 2 diabetes. Type 2 diabetes affects almost 7% of Australia~{!/~}s population. Its incidence continues to grow, as indicated by high rates of metabolic syndrome, a pre-stage of type 2 diabetes. Using novel and bio-molecular techniques, we will evaluate the effects and mechanisms of three natural compounds from anti-diabetic Chinese herbs on cellular and rodent models with metabolic syndrome. This stud ....Development of natural herbal medicines for managing metabolic syndrome in order to prevent type 2 diabetes. Type 2 diabetes affects almost 7% of Australia~{!/~}s population. Its incidence continues to grow, as indicated by high rates of metabolic syndrome, a pre-stage of type 2 diabetes. Using novel and bio-molecular techniques, we will evaluate the effects and mechanisms of three natural compounds from anti-diabetic Chinese herbs on cellular and rodent models with metabolic syndrome. This study will provide scientific evidence as to how and why herbal compounds improve insulin resistance and abnormalities in glucose and lipids metabolism. The outcome of this project will support the development of natural products to manage metabolic syndrome and prevent type 2 diabetes.
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A smartphone rip-detection tool to improve rip current awareness. This project aims to develop a smartphone rip-detection tool and online education game to help reduce the number of Australians drowning in rips each year. The project expects to develop an optimised deep learning algorithm to detect rips from smartphone video taken at Australian beaches, which can then be used by Surf Life Saving Australia for training and education. Expected outcomes of this project are enhanced identification a ....A smartphone rip-detection tool to improve rip current awareness. This project aims to develop a smartphone rip-detection tool and online education game to help reduce the number of Australians drowning in rips each year. The project expects to develop an optimised deep learning algorithm to detect rips from smartphone video taken at Australian beaches, which can then be used by Surf Life Saving Australia for training and education. Expected outcomes of this project are enhanced identification and literacy of rip currents, particularly among priority high-risk demographics like young males, culturally and linguistic diverse communities and rural visitors. This should provide significant benefits in reducing rip-current drowning and rescue incidents in Australia, particularly at unpatrolled beaches.Read moreRead less
Lipidomics Associated with Metabolic Syndrome, Aging and Metabolic Variation between Species. The aim is to apply state-of?the-art mass spectrometry to identify and quantify alterations in membrane lipidomes (i.e. lipid classes, molecular species, structure alterations and by-products) related to two major health problems facing Australia i.e. the Metabolic Syndrome and an Ageing population plus insight into the variation in metabolic rate between organisms. This research offers the opportunity ....Lipidomics Associated with Metabolic Syndrome, Aging and Metabolic Variation between Species. The aim is to apply state-of?the-art mass spectrometry to identify and quantify alterations in membrane lipidomes (i.e. lipid classes, molecular species, structure alterations and by-products) related to two major health problems facing Australia i.e. the Metabolic Syndrome and an Ageing population plus insight into the variation in metabolic rate between organisms. This research offers the opportunity for the development of mass spectrometry based technologies for the early clinical diagnosis of metabolic disorders plus provides a template of information for our Linkage partner (AstraZeneca) to develop pharmaceutical therapies targeting key molecular lipid species identified as critical to particular membrane functions.Read moreRead less
The role of SGK-1 and SGK-2 in hypertension and nephropathy in diabetes mellitus. The key objective is to define the suitability of the serum glucocorticoid regulated kinases -1 and -2 (SGK-1, -2) as novel drug discovery targets. A specific inhibitor targeting SGK-1 and -2 will be tested to determine if it reverses the enhanced sodium reabsorption and extracellular matrix production characteristic of progressive renal failure in in vitro models models of renal disease. These inhibitors present a ....The role of SGK-1 and SGK-2 in hypertension and nephropathy in diabetes mellitus. The key objective is to define the suitability of the serum glucocorticoid regulated kinases -1 and -2 (SGK-1, -2) as novel drug discovery targets. A specific inhibitor targeting SGK-1 and -2 will be tested to determine if it reverses the enhanced sodium reabsorption and extracellular matrix production characteristic of progressive renal failure in in vitro models models of renal disease. These inhibitors present an opportunity to control hypertension whilst simultaneously limiting fibrosis in the kidney. Renal failure is steadily increasing and is now the single largest health care cost to the community. These studies will provide the proof of concept required to ultimately bring this novel preventative therapy to the community.Read moreRead less