Integrative brain imaging technologies. This project aims to develop quantitative metabolic imaging using simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET). The current generation of MR-PET scanners are capable of simultaneously acquiring MRI and PET data to enable quantitative anatomical, physiological and metabolic imaging. The project aims to develop new MRI methods for quantitative anatomical mapping, MR-based motion correction of dynamic PET scan data, and ....Integrative brain imaging technologies. This project aims to develop quantitative metabolic imaging using simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET). The current generation of MR-PET scanners are capable of simultaneously acquiring MRI and PET data to enable quantitative anatomical, physiological and metabolic imaging. The project aims to develop new MRI methods for quantitative anatomical mapping, MR-based motion correction of dynamic PET scan data, and joint estimation of physiological and metabolic organ activity. These advances will create innovative imaging technologies for advanced biomedical imaging research with a particular emphasis in healthy ageing.
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What shapes our brain? This project aims to improve our fundamental understanding of the biological mechanisms that drive folding of the cerebral cortex, which occurs during development of the brain. Cortical folding is unique to humans and higher mammals, and is thought to underpin the emergence of intelligence and contribute to higher-order brain functions. This project will enhance knowledge of how the cerebral cortex folds and develop novel tools for analysing brain development. The project ....What shapes our brain? This project aims to improve our fundamental understanding of the biological mechanisms that drive folding of the cerebral cortex, which occurs during development of the brain. Cortical folding is unique to humans and higher mammals, and is thought to underpin the emergence of intelligence and contribute to higher-order brain functions. This project will enhance knowledge of how the cerebral cortex folds and develop novel tools for analysing brain development. The project will provide significant benefits including the generation of fundamental knowledge with implications for future understanding of cortical folding abnormalities in babies born preterm, following fetal growth retardation in utero, or when exposed to maternal alcohol. In the longer term, the project will contribute to improvements to human neurodevelopment and brain health.Read moreRead less
Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration ....Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration into complex neural networks as well as, (iv) the organisation of neurons into larger 3-dimensional brain structures, namely folding of the human cortex. Further, biomaterials developed here have commercialisation potential, targeted at standardizing the culturing of human stem cells to defined neural populations.
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