Classification of Microarray Gene-Expression Data. The broad aim is to provide statistical methodology for the classification of microarray gene-expression data. Microarrays are part of a new biotechnology that allows the monitoring of expression levels for thousands of genes simultaneously. The explosion in microarrays has produced massive quantities of data that require new statistical techniques for analysis in order to exploit their enormous scientific potential. One of the main uses of ....Classification of Microarray Gene-Expression Data. The broad aim is to provide statistical methodology for the classification of microarray gene-expression data. Microarrays are part of a new biotechnology that allows the monitoring of expression levels for thousands of genes simultaneously. The explosion in microarrays has produced massive quantities of data that require new statistical techniques for analysis in order to exploit their enormous scientific potential. One of the main uses of the methodology to be developed is to expedite the discovery of new subclasses of diseases. Another is to provide prediction rules for the diagnosis and treatment of diseases.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101565
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Flexible data modelling via skew mixture models:challenges and applications. This project seeks to explore new models for handling data with non-normal features. Parametric distributions are fundamental to statistical modelling and inference. For centuries, the ‘normal’ distribution has been the dominant model for continuous data. However, real data rarely satisfy the assumption of normality. There is thus a strong demand for more flexible distributions. This project aims to develop new methodol ....Flexible data modelling via skew mixture models:challenges and applications. This project seeks to explore new models for handling data with non-normal features. Parametric distributions are fundamental to statistical modelling and inference. For centuries, the ‘normal’ distribution has been the dominant model for continuous data. However, real data rarely satisfy the assumption of normality. There is thus a strong demand for more flexible distributions. This project aims to develop new methodologies in finite mixture modelling using skew component distributions to provide better models for handling data with non-normal features (such as skewness, heavy/light tails, and multimodality). Applications may include security intrusion detection, clinical diagnosis and prognosis, and flow and mass cytometry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453501
Funder
Australian Research Council
Funding Amount
$406,097.00
Summary
A Computational Research Grid Serving Regional and Metropolitan Queensland. This project will advance scientific discovery through the development of an integrated, user-friendly computational grid. It significantly enhances Queensland's research capability and infrastructure by delivering state-of-the-art computational resources to researchers at the collaborating institutions and other Queensland and Australia researchers. New supercomputer systems will be integrated into a Queensland wide com ....A Computational Research Grid Serving Regional and Metropolitan Queensland. This project will advance scientific discovery through the development of an integrated, user-friendly computational grid. It significantly enhances Queensland's research capability and infrastructure by delivering state-of-the-art computational resources to researchers at the collaborating institutions and other Queensland and Australia researchers. New supercomputer systems will be integrated into a Queensland wide computational grid being developed by the Queensland Parallel Supercomputing Foundation - an initiative supported by the Queensland State Government. New grid technologies will be employed so that the highest level of support is provided to researchers. This ensures that the facility is used effectively, allowing high-quality research to be efficiently conducted.Read moreRead less
On-line and Incremental EM-based Neural Networks: Application to Hospital Utlilization and Gene Expression Data. Artificial neural networks have been widely applied as universal classifiers in many fields, such as biomedicine. However, misunderstanding of fundamental statistical principles, which can cause misleading findings, has been frequently observed in the literature. This project aims to integrate statistical methodologies in neural networks to provide a unified approach to improve its ....On-line and Incremental EM-based Neural Networks: Application to Hospital Utlilization and Gene Expression Data. Artificial neural networks have been widely applied as universal classifiers in many fields, such as biomedicine. However, misunderstanding of fundamental statistical principles, which can cause misleading findings, has been frequently observed in the literature. This project aims to integrate statistical methodologies in neural networks to provide a unified approach to improve its applicability and efficiency in implementation. The system developed from this proposed cross-disciplinary research will be applied to hospital utilization data (hospital morbidity database, Western Australia) and gene expression data (DNA microarrays databases, Harvard University). This collaborative research will advance the international standard of Australian research communities.
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Unsupervised learning of finite mixture models in data mining applications. The extraction of useful information from massively large databases is known as data mining. Its broad but vague goal is to find "interesting structure" in the data, which typically leads to breaking the data into clusters. To this end, we consider the fast, efficient, and automatic learning of finite mixture models in hugh data sets without any prior knowledge of the structure. This probabilistic approach to the discove ....Unsupervised learning of finite mixture models in data mining applications. The extraction of useful information from massively large databases is known as data mining. Its broad but vague goal is to find "interesting structure" in the data, which typically leads to breaking the data into clusters. To this end, we consider the fast, efficient, and automatic learning of finite mixture models in hugh data sets without any prior knowledge of the structure. This probabilistic approach to the discovery and validation of group structure in data mining applications will considerably enhance knowledge management and decision support in science, industry, and government.
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