A Mathematical Model of the Roles of Contraction and Oxygen in Human Wound Healing. Slow or impaired wound healing and excessive scarring associated with burns are both painful and costly. Moreover, the debilitating effect of chronic wounds can be expected to increase with the continuing aging of the population and the current rise in incidence of Type 2 diabetes. This project brings together a multidisciplinary team to develop a mathematical model of human wound healing and to drive the modelli ....A Mathematical Model of the Roles of Contraction and Oxygen in Human Wound Healing. Slow or impaired wound healing and excessive scarring associated with burns are both painful and costly. Moreover, the debilitating effect of chronic wounds can be expected to increase with the continuing aging of the population and the current rise in incidence of Type 2 diabetes. This project brings together a multidisciplinary team to develop a mathematical model of human wound healing and to drive the modelling to generate important breakthroughs at the level of basic science with implications for both experimentalists and clinicians.Read moreRead less
Innovation in police gender equity management: Looking back, moving forward. This project aims to investigate gender equity recruitment and career support policies in all nine Australian and New Zealand policing agencies. A wide range of equity initiatives that have been implemented across police agencies will be examined, along with affirmative action measures including recent 50/50 male/female recruitment targets. The project expects to generate an advanced best practice model that can be used ....Innovation in police gender equity management: Looking back, moving forward. This project aims to investigate gender equity recruitment and career support policies in all nine Australian and New Zealand policing agencies. A wide range of equity initiatives that have been implemented across police agencies will be examined, along with affirmative action measures including recent 50/50 male/female recruitment targets. The project expects to generate an advanced best practice model that can be used by domestic and international police agencies. This will allow police organisations to better manage equity issues and support a more inclusive and representative workforce. The benefits of this project are significant, they range from stronger police-community relations through to better service delivery by police.Read moreRead less
Targeted crime: policing and social inclusion. This project will undertake a criminological study of the policing of targeted incidents and crime, that is, incidents and crimes motivated by bias, prejudice or hatred towards members of particular groups, communities and individuals. It will develop a best practice policing framework for targeted crimes and incidents.
Development of a Prothrombogenic Bone Graft Substitute. The clinical demand for bone is massive and to counter this bone can be either harvested from the patient or bone substitutes are used. The success or failure of a bone substitute is determined the instant it come into contact with blood. The surfaces of traditional biomaterials induce a foreign body reaction. The aim of this project is to test the bone forming capacity of a biomaterial that is optimised to produce a natural response from ....Development of a Prothrombogenic Bone Graft Substitute. The clinical demand for bone is massive and to counter this bone can be either harvested from the patient or bone substitutes are used. The success or failure of a bone substitute is determined the instant it come into contact with blood. The surfaces of traditional biomaterials induce a foreign body reaction. The aim of this project is to test the bone forming capacity of a biomaterial that is optimised to produce a natural response from the blood. This response will lead to the formation new viable tissue and eventually bone. Such a material will cause faster bone healing, less pain from graft sites, shorter hospital stays and shorter waiting lists. Read moreRead less
An early warning system for police workplace health and performance. This project aims to build a comprehensive organisational model of police workplace health and performance. This project answers the call for immediate organisational reform of police workplaces resulting from an Australian national study (2018) and Australian Senate Inquiry (2019). Police experience harm that must be addressed through organisational improvements, leading to more efficient policing. In the first study of its ki ....An early warning system for police workplace health and performance. This project aims to build a comprehensive organisational model of police workplace health and performance. This project answers the call for immediate organisational reform of police workplaces resulting from an Australian national study (2018) and Australian Senate Inquiry (2019). Police experience harm that must be addressed through organisational improvements, leading to more efficient policing. In the first study of its kind, this project will develop a practical early warning system that promotes strategic and front-line leadership capability of Australian police agencies in workplace health and performance. It will allow better identification of risk, resource allocation and tracking of these critical issues in policing.Read moreRead less
Detection and Quantification of General Fetal Movements from Accelerometer Measurements using Nonstationary Signal Processing Techniques. There are approximately 1,750 fetal deaths per year in Australian with about one-third occurring late in gestation and without an apparent cause. The development of an automated system capable of long-term monitoring of fetal health will result in accurate diagnoses and prediction of future outcome. This will, in turn, allow early intervention by the clinicia ....Detection and Quantification of General Fetal Movements from Accelerometer Measurements using Nonstationary Signal Processing Techniques. There are approximately 1,750 fetal deaths per year in Australian with about one-third occurring late in gestation and without an apparent cause. The development of an automated system capable of long-term monitoring of fetal health will result in accurate diagnoses and prediction of future outcome. This will, in turn, allow early intervention by the clinician to reduce fetal deaths and enhance the chances of good outcomes with resultant savings in social and financial costs to the community. The development of such equipment would spawn future research into intervention treatments and contribute to Australia's position as a world leader in computerised health monitoring systems.Read moreRead less
Multi-Channel Time-Frequency Analysis for EEG Neonatal Seizure Characterization. This project researches new signal processing methodologies for a multi-channel characterization of seizures for use in diagnosing newborn brain dysfunctions. The outcomes will result in important immediate clinical benefits for sick newborn babies and will fundamentally facilitate research progress in the development of neuroprotectants and anticonvulsants. The success of this project will contribute in minimizing ....Multi-Channel Time-Frequency Analysis for EEG Neonatal Seizure Characterization. This project researches new signal processing methodologies for a multi-channel characterization of seizures for use in diagnosing newborn brain dysfunctions. The outcomes will result in important immediate clinical benefits for sick newborn babies and will fundamentally facilitate research progress in the development of neuroprotectants and anticonvulsants. The success of this project will contribute in minimizing the social financial costs by diagnosing brain disorders in the initial stage of life and preventing further damage. This has the potential to result in a standard diagnostic equipment in neonatal intensive care units and medical research centres.Read moreRead less
Design of Neonatal Seizure Diagnosis Methods Using Time-Frequency Signal Processing Techniques. Seizures occur in approximately 0.5% of all newborns. They are often the only indicator of an early dysfunction in central nervous system (CNS). Their occurrence raises concerns about the underlying cause, its effect on the brain, and the appropriate treatment. Newborn seizures are mostly sub-clinical and only detected through the Electroencephalogram. For an efficient diagnosis, seizure classificatio ....Design of Neonatal Seizure Diagnosis Methods Using Time-Frequency Signal Processing Techniques. Seizures occur in approximately 0.5% of all newborns. They are often the only indicator of an early dysfunction in central nervous system (CNS). Their occurrence raises concerns about the underlying cause, its effect on the brain, and the appropriate treatment. Newborn seizures are mostly sub-clinical and only detected through the Electroencephalogram. For an efficient diagnosis, seizure classification systems were proposed based on visual observations. This project proposes developing a novel approach to automate the classification process using time-frequency (TF) signal processing techniques based on the multi-channel characteristics of the seizure; namely: A) TF signature B) origin, and C) propagation behaviour.Read moreRead less
Non-invasive diagnosis using micropatches that sample biomarkers from skin. We are developing a technology called the micropatch that is laid onto the surface of the skin. When the patch is pulled away, it retains proteins found in the subsurface skin layers. We believe that by analysing these proteins we will be able to diagnose diseases like cancer earlier and therefore have a better chance of treating them successfully. The process is painless, and doctors already use it to give drugs and vac ....Non-invasive diagnosis using micropatches that sample biomarkers from skin. We are developing a technology called the micropatch that is laid onto the surface of the skin. When the patch is pulled away, it retains proteins found in the subsurface skin layers. We believe that by analysing these proteins we will be able to diagnose diseases like cancer earlier and therefore have a better chance of treating them successfully. The process is painless, and doctors already use it to give drugs and vaccines. In the future we hope that our technology will be simple enough for routine diagnosis, even in the Outback where doctors are hundreds of kilometres awayRead moreRead less
Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics ....Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics for use in real world applications. The project has two aspects. First, relatively small directed cDNA-bead libraries will be compared to known low-density cDNA microarrays to validate the technique for utility in gene expression profiling. Secondly, large libraries containing short oligonucleotide sequences will be used for de novo sequencing of a complete transcriptome. Proof-of-concept in either case will pave the way for many genomic applications and catapult the technology to 'blockbuster' status.Read moreRead less