MICROFABRICATED DEVICES: A SIGNIFICANT ADVANCE FOR THE DETECTION AND MOLECULAR ANALYSES OF CIRCULATING CANCER CELLS?
Funder
National Health and Medical Research Council
Funding Amount
$422,107.00
Summary
Using advanced microfabrication concepts, this project aims to develop a platform technology able to capture tumour cells circulating in the blood of cancer patients. Although present only in extremely small numbers, these cells provide invaluable insights into the pathophysiology of the disease and consequently provide vital diagnostic and prognostic information. Molecular analyses of these cancer cells could ultimately enable the design of improved and personalized cancer treatment.
Development of an implantable device to monitor lactate levels in blood: Monitoring the Performance of Australian athletes using Biosensor Technology. Sport is a critical area for social and economic investments. Novel medical monitoring systems using implantable biosensors will ensure optimal training programs for Australian athletes and maintain international competitiveness. Here we are developing a biosensor for real-time monitoring of lactate levels in athletes using frontier porous semicon ....Development of an implantable device to monitor lactate levels in blood: Monitoring the Performance of Australian athletes using Biosensor Technology. Sport is a critical area for social and economic investments. Novel medical monitoring systems using implantable biosensors will ensure optimal training programs for Australian athletes and maintain international competitiveness. Here we are developing a biosensor for real-time monitoring of lactate levels in athletes using frontier porous semiconductor technology and smart telemetry protocols to transfer the readings to a remote base unit. These highly innovative devices and the materials that they are made from have enormous commercial potential in biomedical engineering. There is a strong potential for Australia to have an important stake in this area by combining expertise in engineering, chemistry and nanostructured materials.Read moreRead less
Innovation in agricultural sector Green House Gas abatement in NSW. This project aims to develop a land sector greenhouse gas abatement, food production and environmental economics model for NSW. We expect to identify innovation in carbon payment policy and brokerage business models to achieve agricultural GHG abatement, while simultaneously improving sustainability. Expected outcomes include evaluation of the innovations of expert landholders, related businesses and governments to find ways to ....Innovation in agricultural sector Green House Gas abatement in NSW. This project aims to develop a land sector greenhouse gas abatement, food production and environmental economics model for NSW. We expect to identify innovation in carbon payment policy and brokerage business models to achieve agricultural GHG abatement, while simultaneously improving sustainability. Expected outcomes include evaluation of the innovations of expert landholders, related businesses and governments to find ways to influence land use decisions. This should provide significant benefits to landholders, governments involved in land management and the public through increased productivity, profitability, biodiversity and ecosystem health in the context of future climate, agricultural commodity and carbon market uncertainties.Read moreRead less
Moving beyond crisis management: Creating a future for people with disabilities living with ageing parents. The needs of thousands of people with disabilities being cared for by ageing parents are beyond the capacity of our existing formal mechanisms for providing care. In order to mitigate this national crisis in support, this research will establish effective, resource efficient support strategies where there are currently no plans in place for future care arrangements. By enhancing the capaci ....Moving beyond crisis management: Creating a future for people with disabilities living with ageing parents. The needs of thousands of people with disabilities being cared for by ageing parents are beyond the capacity of our existing formal mechanisms for providing care. In order to mitigate this national crisis in support, this research will establish effective, resource efficient support strategies where there are currently no plans in place for future care arrangements. By enhancing the capacity of the community to provide support the benefit of existing formal supports will be extended to address the needs of more families. This project will position Australian disability research and support at the forefront of international efforts to legitimize the claim of people with disabilities and their families on community resources.Read moreRead less
Support needs assessment: a developmental model for use in support, training and funding for individuals with single and multiple disabilities. This research project aims to construct and trial a new model for the assessment of the support needs of persons with disabilities. It addresses a number of critical deficiencies which recent research has shown to undermine the reliability, validity and usefulness of existing support needs instruments. Specifically, it is proposed to collect data that ....Support needs assessment: a developmental model for use in support, training and funding for individuals with single and multiple disabilities. This research project aims to construct and trial a new model for the assessment of the support needs of persons with disabilities. It addresses a number of critical deficiencies which recent research has shown to undermine the reliability, validity and usefulness of existing support needs instruments. Specifically, it is proposed to collect data that will inform the determination of the support needs of people with different kinds and combinations of disabilities. Variations in maintenance and intervention supports over time and context will be considered. The assessment system planned will have the flexibility to meet a number of potential user objectives.Read moreRead less
Porous silicon biosensor for rapid detection of water-borne contaminants. We have recently demonstrated the rapid degradation of porous silicon by certain transition metal complexes known as biomimetic catalysts. The catalysed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. Using this mechanism, we will develop a biosensor for the rapid detection of contaminants (toxins etc.) in water resources. Reservoir w ....Porous silicon biosensor for rapid detection of water-borne contaminants. We have recently demonstrated the rapid degradation of porous silicon by certain transition metal complexes known as biomimetic catalysts. The catalysed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. Using this mechanism, we will develop a biosensor for the rapid detection of contaminants (toxins etc.) in water resources. Reservoir water treatment today is reactive rather than preventive because current analysis is slow. Our biosensor can be turned into a field kit to improve water quality management and prevent acts of deliberate sabotage to the water supply.Read moreRead less
Development of an interferometric nanoscale silicon biosensor. Voelcker et al. have recently demonstrated the rapid degradation of porous silicon by certain supramolecular transition metal complexes known as functional mimics of metalloproteins. The catalyzed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. This project uses porous silicon degradation to develop a biosensor platform capable of detecting a ra ....Development of an interferometric nanoscale silicon biosensor. Voelcker et al. have recently demonstrated the rapid degradation of porous silicon by certain supramolecular transition metal complexes known as functional mimics of metalloproteins. The catalyzed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. This project uses porous silicon degradation to develop a biosensor platform capable of detecting a range of analytes with high sensitivity. The project includes detection of an water-borne toxin, a plant virus and a cancer antigen as demonstrators of its wide applicability. Multiplexing of the biosensor to demonstrate its potential as high-throughput chip sensors is also included.Read moreRead less
Personalised Medicine Markers Of Anti-EGFR Antibody Therapy In Metastatic Colorectal Cancer: Accelerating Clinical Translation With Collaborative Meta-analyses Based On Individual-participant Data
Funder
National Health and Medical Research Council
Funding Amount
$300,953.00
Summary
When selecting cancer therapy we take into account ‘biomarkers’, biological cancer characteristics that predict treatment success. We will work with an international group, the Advanced Colorectal Cancer Database, to analyse individual patient clinical trial data. We intend to validate biomarkers used to select treatment with cetuximab or panitumumab. Cancer genes called KRAS, NRAS, PTEN, PIK3CA, EREG and BRAF will be examined. Our study will provide best evidence for personalised treatment.
Advanced Nanostructured Biointerfaces for Cell Capture. The expected outcomes of this interdisciplinary project, which apply the most recent advances in nanotechnology and biophysics to cancer research, will enhance Australia's capacity in Frontier Technology and build strength in Nanobiotechnology. They will bring competitive advantages to the Australian biotechnology and biomedical community for further developments and applications in the multi-billion dollar field of biodiagnostics. These in ....Advanced Nanostructured Biointerfaces for Cell Capture. The expected outcomes of this interdisciplinary project, which apply the most recent advances in nanotechnology and biophysics to cancer research, will enhance Australia's capacity in Frontier Technology and build strength in Nanobiotechnology. They will bring competitive advantages to the Australian biotechnology and biomedical community for further developments and applications in the multi-billion dollar field of biodiagnostics. These innovative biodiagnostic strategies will potentially achieve a significant step in the direction of the once elusive goal of early detection and improved understanding of cancer.Read moreRead less
Special Research Initiatives - Grant ID: SR0354583
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Biodevice fabrication through intelligent surface modification. Achieving the reliable control of the attachment of proteins and other macromolecules to surfaces needed for sophisticated biosensors and medical diagnostics requires expertise and infrastructure from a diverse range of disciplines from the physical, chemical and biological sciences and engineering. This network will bring together researchers from a multidisciplinary pool working on problems relevant to the creation of functional s ....Biodevice fabrication through intelligent surface modification. Achieving the reliable control of the attachment of proteins and other macromolecules to surfaces needed for sophisticated biosensors and medical diagnostics requires expertise and infrastructure from a diverse range of disciplines from the physical, chemical and biological sciences and engineering. This network will bring together researchers from a multidisciplinary pool working on problems relevant to the creation of functional surfaces for applications in biodevices. The program we envisage will break down the barriers imposed by disciplinary boundaries and technical terminology to bring together the skills and infrastructure required to make rapid advances in this field.Read moreRead less