Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Miniaturised biosensors with high selectivity . This project aims to develop a technological platform for the fabrication of miniaturised and flexible sensors that enable the quantitative detection of important bioactive compounds such as fatty acids and biogenic amines. By utilising multi-enzymatic reactions in solid phase and engineering task-specific inks, chemiresistive sensors will be printed seamlessly as a whole. The sensors will respond to complex target biomolecules via a series of enzy ....Miniaturised biosensors with high selectivity . This project aims to develop a technological platform for the fabrication of miniaturised and flexible sensors that enable the quantitative detection of important bioactive compounds such as fatty acids and biogenic amines. By utilising multi-enzymatic reactions in solid phase and engineering task-specific inks, chemiresistive sensors will be printed seamlessly as a whole. The sensors will respond to complex target biomolecules via a series of enzymatic reactions through which the analyte will convert to much simpler, reactive and hence measurable molecules. This project will enable to design miniaturised sensors for point-of-care detection of biomolecules that cannot be yet evaluated by the end users.Read moreRead less
How electric fields can facilitate reversible protein binding to surfaces. The aim of this project is to develop the first biosensors that prevent nonspecific protein adsorption and allow reversible protein binding. The project expects to achieve this using a combination of novel surface chemistry and pulsed electric fields that dynamically change a sensing interface. The impact of electric fields on the binding of proteins to this interface will be followed using a novel single molecule fluores ....How electric fields can facilitate reversible protein binding to surfaces. The aim of this project is to develop the first biosensors that prevent nonspecific protein adsorption and allow reversible protein binding. The project expects to achieve this using a combination of novel surface chemistry and pulsed electric fields that dynamically change a sensing interface. The impact of electric fields on the binding of proteins to this interface will be followed using a novel single molecule fluorescence microscope previously developed that can locate the position of proteins with 2 nanometer resolution. The expected outcomes of this project is a class of biosensor that can continuously monitor protein biomarkers for wearable sensors that provide information on a user’s wellness and nutrition.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100846
Funder
Australian Research Council
Funding Amount
$418,388.00
Summary
Ordering photon energy carriers for efficient upconversion. This project aims to tackle the major challenge of upconversion nanosystems – their brightness. It will centre on building a donor/acceptor-ordered nanosystem to improve the energy transfer efficiency in hybrid nanomaterials. This ordered system will significantly improve the brightness of hybrid nanoparticles at low irradiance. Expected outcomes include a fundamental understanding of energy transfer mechanisms at sub-nm scales and a ne ....Ordering photon energy carriers for efficient upconversion. This project aims to tackle the major challenge of upconversion nanosystems – their brightness. It will centre on building a donor/acceptor-ordered nanosystem to improve the energy transfer efficiency in hybrid nanomaterials. This ordered system will significantly improve the brightness of hybrid nanoparticles at low irradiance. Expected outcomes include a fundamental understanding of energy transfer mechanisms at sub-nm scales and a new strategy to brighten the upconversion nanomaterials. This project should push upconversion nanoscience to a new generation and provide significant benefits in ultra-sensitive biomolecular assays and in vivo bioimaging.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101137
Funder
Australian Research Council
Funding Amount
$458,665.00
Summary
Exploiting biological noise for next generation electrochemical biosensors. This project aims to harness the intrinsic noise in a biological system to develop a new platform for biosensors. This will lead to advancement of a new versatile electrochemical platform for real-time screening with vast applications that span from sensing at sub-cellular level to point-of-care and implantable biosensors. The new sensory technique will improve the specificity, sensitivity and resolution in biosensors an ....Exploiting biological noise for next generation electrochemical biosensors. This project aims to harness the intrinsic noise in a biological system to develop a new platform for biosensors. This will lead to advancement of a new versatile electrochemical platform for real-time screening with vast applications that span from sensing at sub-cellular level to point-of-care and implantable biosensors. The new sensory technique will improve the specificity, sensitivity and resolution in biosensors and enables measurement of multiple biomarkers simultaneously in real-time. The outcomes will contribute to a better understanding of fundamental physiological processes and chemical interactions at subcellular level which will inform future advancements in biomedical engineering.
Read moreRead less
Integrative brain imaging technologies. This project aims to develop quantitative metabolic imaging using simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET). The current generation of MR-PET scanners are capable of simultaneously acquiring MRI and PET data to enable quantitative anatomical, physiological and metabolic imaging. The project aims to develop new MRI methods for quantitative anatomical mapping, MR-based motion correction of dynamic PET scan data, and ....Integrative brain imaging technologies. This project aims to develop quantitative metabolic imaging using simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET). The current generation of MR-PET scanners are capable of simultaneously acquiring MRI and PET data to enable quantitative anatomical, physiological and metabolic imaging. The project aims to develop new MRI methods for quantitative anatomical mapping, MR-based motion correction of dynamic PET scan data, and joint estimation of physiological and metabolic organ activity. These advances will create innovative imaging technologies for advanced biomedical imaging research with a particular emphasis in healthy ageing.
Read moreRead less