Understanding The Role Of Sugar Metabolism In Liver Tumour Growth
Funder
National Health and Medical Research Council
Funding Amount
$631,979.00
Summary
Primary liver cancer is a deadly disease with limited chemotherapeutic options. The investigators of this proposal have recently determined that sugar intake (but not fat or complex carbohydrate) is a dominant driver of liver tumour growth in mice. The current proposal will investigate the specific contributions of glucose versus fructose in tumour burden, and determine whether blocking the conversion of sugars to fat in the liver represents a therapeutic strategy to block tumour growth in mice.
Mechanisms Of Weight And Adipose Loss Following Inhibition Of The Renin-angiotensin System
Funder
National Health and Medical Research Council
Funding Amount
$330,722.00
Summary
As an energy homeostasis researcher, with a particular interest in ingestive behaviour, I plan to examine the role the renin-angiotensin system in energy balance and obesity. I will achieve this by spending two years learning new techniques and conducting research in one of the top energy balance labs in the world, headed by Professor Stephen Woods (University of Cincinnati). I will then return to Australia to implement the techniques I have learned and extend this research.
Defining Factors That Contribute To Individual Diversity In The Diet-health Axis
Funder
National Health and Medical Research Council
Funding Amount
$1,668,059.00
Summary
There is a complex interplay between nutrition and genetics such that one diet maybe good for some but not for others depending on genetic makeup. Preliminary experiments in flies and mice support this. We found that for some flies, diets high in fat are harmful resulting in short life but certain flies resist the harmful effects of fat and live a longer lives. We propose to unravel the gene-environment interaction and determine which genes might lead to optimal health outcomes on certain diets.