Improving Weight Loss By Intermittent Use Of Very Low Energy Diet: The TANGO Diet Trial (Temporary Phases Of Accelerated Weight Loss For Noticeably Greater Outcomes)
Funder
National Health and Medical Research Council
Funding Amount
$660,736.00
Summary
Very low energy diet (VLED) is being increasingly used for the treatment of obesity, but the resultant weight loss is usually transient, partly because it induces powerful adaptive responses that inhibit weight loss and promote regain. We have shown that 'taking a break from dieting' for 2 weeks reduces these adaptive responses. In this project we will thus test whether weight loss outcomes with VLED can be improved via intermittent use, where periods on the VLED are alternated with 'breaks'.
Effects Of Fast Versus Slow Weight Loss On Fat, Muscle And Bone In Postmenopausal Women
Funder
National Health and Medical Research Council
Funding Amount
$316,450.00
Summary
Very low energy diets (VLED) are increasingly used to treat obesity. Of concern is the fact that VLED induce adaptive responses that can inhibit loss of, and promote regain of, abdominal fat while decreasing lean body mass, muscle strength and bone density. This project will therefore determine whether VLEDs could have negative effects on body composition that increase the risk of metabolic disease, sarcopenia or osteoporosis, and if so, what mechanisms are involved.
This proposal is designed to test the protein leverage hypothesis (PLH) in humans: the idea that the level of food consumption in humans, like other animals, is adjusted to maintain a target protein intake. As the prevalence of overweight and obesity increases, with its attendant health problems, the need to identify which dietary components limit rather than exacerbate energy intake is imperative. According to the PLH, the consumption of a diet low in % protein and high in % fat and carbohydrat ....This proposal is designed to test the protein leverage hypothesis (PLH) in humans: the idea that the level of food consumption in humans, like other animals, is adjusted to maintain a target protein intake. As the prevalence of overweight and obesity increases, with its attendant health problems, the need to identify which dietary components limit rather than exacerbate energy intake is imperative. According to the PLH, the consumption of a diet low in % protein and high in % fat and carbohydrate, typical of many Western countries, inevitably requires the ingestion of additional energy to maintain protein intake constant, thus driving weight gain. Conversely, the consumption of a diet that is relatively high in % protein requires the ingestion of lower levels of energy, creating the potential for weight loss. Preliminary experimental and population-level nutritional survey data support the PLH, as does the finding that protein is more satiating than other macronutrients. If, as predicted, small changes in the proportion of protein in diets described in the current study are found to impact on total energy intake there will be significant implications for weight control strategies. Thus, if the PLH is confirmed, public health dietary recommendations and government policy settings for the food industry will need to change. Large-scale intervention studies aimed at demonstrating the longer term impact on body weight will also be required.Read moreRead less
Atmospheric composition and climate change. Changing composition and distribution of atmospheric trace gases and aerosols are the driving forces behind changes in climate and the environment at the earth's surface. This proposal is to undertake a program of ground based infrared remote sensing measurements as part of the Network for Detection of Stratospheric Change to investigate some of the most relevant atmospheric processes and species central to the greenhouse effect and ozone depletion. S ....Atmospheric composition and climate change. Changing composition and distribution of atmospheric trace gases and aerosols are the driving forces behind changes in climate and the environment at the earth's surface. This proposal is to undertake a program of ground based infrared remote sensing measurements as part of the Network for Detection of Stratospheric Change to investigate some of the most relevant atmospheric processes and species central to the greenhouse effect and ozone depletion. State-of-the-art measurements, advances in analysis techniques, and the measurement of isotopic fractionation will all contribute to advances in capabilities. Validation of satellite-based remote sensing instruments is also an important facet of the work.Read moreRead less
Better greenhouse gas budgets: new techniques and applications. The most recent (2001) international assessment strongly confirms the link between global climate change and human-induced changes in atmospheric composition. However, improved knowledge of atmospheric trace gas budgets is essential for better modelling of future climate change and formulation of public policy. We have developed novel techniques for atmospheric trace gas and isoptic analysis that provide new tools for resolving trac ....Better greenhouse gas budgets: new techniques and applications. The most recent (2001) international assessment strongly confirms the link between global climate change and human-induced changes in atmospheric composition. However, improved knowledge of atmospheric trace gas budgets is essential for better modelling of future climate change and formulation of public policy. We have developed novel techniques for atmospheric trace gas and isoptic analysis that provide new tools for resolving trace gas budgets in ways not previously possible. We will apply these tools to improve our understanding of the Australian and global budgets of greenhouse gases, especially nitrous oxide and methane, for which sources still have unacceptably large uncertainties.Read moreRead less
Innovative measurement and modelling of greenhouse fluxes at regional scales across Australia. Carbon dioxide accounts for around 60% of the enhanced greenhouse effect. This proposal aims to markedly improve knowledge of the exchange of carbon, mostly as CO2, between atmospheric, ocean and land-based reservoirs in the Australian region. This will be achieved through a suite of measurements using innovative technologies: satellite and ground based remote sensing as well in situ measurements at ....Innovative measurement and modelling of greenhouse fluxes at regional scales across Australia. Carbon dioxide accounts for around 60% of the enhanced greenhouse effect. This proposal aims to markedly improve knowledge of the exchange of carbon, mostly as CO2, between atmospheric, ocean and land-based reservoirs in the Australian region. This will be achieved through a suite of measurements using innovative technologies: satellite and ground based remote sensing as well in situ measurements at Darwin and on the Ghan railway from Darwin to Adelaide. The measurements will be used to constrain inverse models of the carbon cycle and significantly reduce uncertainties in regional carbon source estimates. These estimates will in turn be compared to the Australian National Greenhouse Gas Inventory for comparison and verification.Read moreRead less
The carbon cycle and climate: new approaches to atmospheric measurements and modelling. Earth's climate is intimately connected to the carbon cycle, which controls atmospheric CO2 through processes such as photosynthesis, respiration and ocean uptake. A thorough understanding of the carbon cycle, and potential feedbacks with climate change, is prerequisite knowledge for informed assessments of future climate, impacts, adaptation and mitigation. This proposal improves that understanding through ....The carbon cycle and climate: new approaches to atmospheric measurements and modelling. Earth's climate is intimately connected to the carbon cycle, which controls atmospheric CO2 through processes such as photosynthesis, respiration and ocean uptake. A thorough understanding of the carbon cycle, and potential feedbacks with climate change, is prerequisite knowledge for informed assessments of future climate, impacts, adaptation and mitigation. This proposal improves that understanding through measurements of CO2 and other key Kyoto-protocol greenhouse gases, links to global networks and satellite measurements, and advanced modelling. Australian science has a very important role to play in international networks due to our unique combination of southern hemisphere location and scientific standing. Read moreRead less
Biomass Burning Emissions - An Innovative Technique for Assessing Global Climate Impacts. This proposal will significantly improve our understanding of the impacts of biomass burning on climate and environmental change leading to better predictive powers and more informed political and economic responses to issues such as Australian compliance with international protocols dealing with global climate change (Kyoto). Further, it will help the development of Australian expertise in global chemical ....Biomass Burning Emissions - An Innovative Technique for Assessing Global Climate Impacts. This proposal will significantly improve our understanding of the impacts of biomass burning on climate and environmental change leading to better predictive powers and more informed political and economic responses to issues such as Australian compliance with international protocols dealing with global climate change (Kyoto). Further, it will help the development of Australian expertise in global chemical transport modelling not currently addressed by other Australian research programs.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668470
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
High resolution Fourier transform infrared spectrometer for atmospheric remote sensing and laboratory spectroscopy. Climate change is a major global concern, with the potential for major consequences in Australia. This proposal contributes directly to climate change research relevant to Australia through direct measurements of the atmosphere relevant to the understanding of phenomena such as increasing greenhouse gas concentrations and stratospheric ozone depletion. Australia's geographical posi ....High resolution Fourier transform infrared spectrometer for atmospheric remote sensing and laboratory spectroscopy. Climate change is a major global concern, with the potential for major consequences in Australia. This proposal contributes directly to climate change research relevant to Australia through direct measurements of the atmosphere relevant to the understanding of phenomena such as increasing greenhouse gas concentrations and stratospheric ozone depletion. Australia's geographical position in the less populated southern hemisphere, and its advanced scientific infrastructure, mean that it has an especially important and valuable role to play in global atmospheric research. The proposed research participates in several international research programmes.Read moreRead less
The behaviour of geochemical tracers during differentiation of the Earth. This project is aimed at providing fundamental data which Earth Scientists will use to understand the processes by which the Earth separated into its chemically-distinct layers (core, mantle, crust, atmosphere, oceans) and to determine the nature of the continuing interactions between the surface environment in which we live and the deep interior. It will provide training in modern high temperature-high pressure materials- ....The behaviour of geochemical tracers during differentiation of the Earth. This project is aimed at providing fundamental data which Earth Scientists will use to understand the processes by which the Earth separated into its chemically-distinct layers (core, mantle, crust, atmosphere, oceans) and to determine the nature of the continuing interactions between the surface environment in which we live and the deep interior. It will provide training in modern high temperature-high pressure materials-science techniques for Ph.D. students and postdoctoral researchers. This will provide Australia with Earth Scientists who have both traditional skills and the ability to work with Materials Scientists on the synthesis of novel materials under extreme conditions.Read moreRead less