Surveillance Of LGV Chlamydia Trachomatis Types Among Men Who Have Sex With Men (MSM)
Funder
National Health and Medical Research Council
Funding Amount
$194,875.00
Summary
Chlamydia is a common sexually transmitted infection (STI) caused by the bacterium, Chlamydia trachomatis (CT). Annually, 50 million new cases of chlamydia are estimated to occur worldwide which if untreated, can lead to serious complications such as pelvic inflammatory disease and infertility in women and epididymitis in men. Over the past decade, there has been a sharp increase in diagnoses of chlamydia in Australia, coinciding with a reported upsurge in sexual risk behaviour (increased partne ....Chlamydia is a common sexually transmitted infection (STI) caused by the bacterium, Chlamydia trachomatis (CT). Annually, 50 million new cases of chlamydia are estimated to occur worldwide which if untreated, can lead to serious complications such as pelvic inflammatory disease and infertility in women and epididymitis in men. Over the past decade, there has been a sharp increase in diagnoses of chlamydia in Australia, coinciding with a reported upsurge in sexual risk behaviour (increased partner numbers and-or practices of unprotected sex), particularly among men who have sex with men (MSM). In addition, there are current outbreaks of an invasive CT strain, causing lymphogranuloma venereum (LGV), throughout Western Europe, with cases now reported in the USA. LGV can lead to severe anogenital ulcers, which can increase transmission of HIV, hepatitis C, and other STIs. With growing international travel, the likelihood of LGV outbreaks in Australia, particularly in MSM, is increased. Recently, isolated cases of LGV have been noted in MSM attending Sydney and Melbourne Sexual Health Centres, indicating LGV is possibly already in circulation. Since we know little about circulating CT types in Australia it would be difficult to assess the burden of an LGV outbreak. Due to increasing CT infections and likely risk of increased HIV transmission, particularly with LGV strains, surveillance of CT genotypes in Australia, especially in MSM, is important. The purpose of this study is to type CT strains in our population by looking at their genetic makeup. CT-positive specimens from Melbourne and Sydney will be used to identify CT types in circulation and to assess if LGV types are present. The knowledge obtained from this study will be novel and invaluable, and could contribute considerably to the development of improved disease prevention and intervention strategies, including the design of vaccines.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101348
Funder
Australian Research Council
Funding Amount
$328,075.00
Summary
Singularity analysis for ricci flow and mean curvature flow. This project aims to investigate the central problem of singularity formation in Ricci flow and mean-curvature flow by profiling singular solutions and determining their stability and genericity. Geometric flows are powerful and successful ways of understanding classical problems in geometry and topology with applications in disciplines such as materials science and medical imaging. This project will generate significant results in sin ....Singularity analysis for ricci flow and mean curvature flow. This project aims to investigate the central problem of singularity formation in Ricci flow and mean-curvature flow by profiling singular solutions and determining their stability and genericity. Geometric flows are powerful and successful ways of understanding classical problems in geometry and topology with applications in disciplines such as materials science and medical imaging. This project will generate significant results in singularity analysis and will enrich understanding of geometric flows at and past singularities, deepen the theory of geometric flows, and enhance their applications in mathematics and science.Read moreRead less
Higher order curvature flow of curves and hypersurfaces. This project aims to analyse higher order geometric partial differential equations that have important mathematical applications in differential geometry of submanifolds as well as practical applications in physics and mathematical biology. The project aims to prove new general principles that reveal properties of these higher order elliptic and parabolic partial differential equations, producing a unified framework with applications to va ....Higher order curvature flow of curves and hypersurfaces. This project aims to analyse higher order geometric partial differential equations that have important mathematical applications in differential geometry of submanifolds as well as practical applications in physics and mathematical biology. The project aims to prove new general principles that reveal properties of these higher order elliptic and parabolic partial differential equations, producing a unified framework with applications to various specific problems. This project aims to increase Australia's research capacity in geometric evolution problems, provide training for some of Australia's next generation of mathematicians and build Australia's international reputation for significant research in geometric analysis.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101834
Funder
Australian Research Council
Funding Amount
$418,410.00
Summary
The structure of singularities in geometric flows. The proposed research aims to develop our understanding of the structure of singularities in mean curvature and related flows, with certain applications in mind.
Discovery Early Career Researcher Award - Grant ID: DE190101241
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Gauged sigma model, mirror symmetry, and related topics. This project aims to lay down a rigorous mathematical foundation of the gauged linear sigma model and seek its mathematical applications. The gauged linear sigma model is an important theory introduced by the great physicist Edward Witten. It is a fundamental framework in studying superstring theory, which is one of the most promising candidates for the unification of all aspects of physics. This project will generate new and significant r ....Gauged sigma model, mirror symmetry, and related topics. This project aims to lay down a rigorous mathematical foundation of the gauged linear sigma model and seek its mathematical applications. The gauged linear sigma model is an important theory introduced by the great physicist Edward Witten. It is a fundamental framework in studying superstring theory, which is one of the most promising candidates for the unification of all aspects of physics. This project will generate new and significant results in geometry, with many benefits, providing solid mathematical foundations of the gauged linear sigma model, deepening the understanding of this theory, and providing new methods for solving classical problems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100110
Funder
Australian Research Council
Funding Amount
$343,450.00
Summary
Analysis of fully non-linear geometric problems and differential equations. This project aims to investigate non-linear geometric evolution equations that have received considerable attention in the past decades through their use in solving outstanding problems in mathematics, such as the Poincare conjecture. By developing innovative new techniques intertwining geometry and analysis, the project endeavours to make advances in non-linear problems modelling complex phenomena. The project addresses ....Analysis of fully non-linear geometric problems and differential equations. This project aims to investigate non-linear geometric evolution equations that have received considerable attention in the past decades through their use in solving outstanding problems in mathematics, such as the Poincare conjecture. By developing innovative new techniques intertwining geometry and analysis, the project endeavours to make advances in non-linear problems modelling complex phenomena. The project addresses topics as varied as hyperbolic geometry, and a geometric approach to irregularities forming in crystal growth in materials science, focusing on developing cutting-edge mathematical tools and connections to geometry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100379
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Curvature flow of clusters: optimal partitioning and merging fire fronts. This project aims to develop the curvature flow of clusters, a new mathematical innovation that builds on methods with proven success in making new progress on difficult problems in geometry and topology. The curvature flow of clusters will allow foams - partitions of space - to be viewed dynamically. This allows long-standing problems on their structure, a key mathematical challenge in material science, to be studied in a ....Curvature flow of clusters: optimal partitioning and merging fire fronts. This project aims to develop the curvature flow of clusters, a new mathematical innovation that builds on methods with proven success in making new progress on difficult problems in geometry and topology. The curvature flow of clusters will allow foams - partitions of space - to be viewed dynamically. This allows long-standing problems on their structure, a key mathematical challenge in material science, to be studied in a natural context. The project is expected to produce a software suite capable of simulating the movement of merging fire fronts with better accuracy than ever before. The mathematical tools developed by the project will have broad applicability, not only to space partitioning but also notably to bushfires, especially on the dynamics of merging fire fronts.Read moreRead less
Monge-Ampere type equations and their applications. The study of Monge-Ampere equations has attracted major attention in mathematics in recent years, due to many significant applications in geometry, physics and applied science. This project aims to resolve challenging problems involving Monge-Ampere type equations, by utilising new ideas and breakthroughs made by the proposer. A comprehensive regularity theory for Monge-Ampere type equations, particularly in the degenerate case, is expected to ....Monge-Ampere type equations and their applications. The study of Monge-Ampere equations has attracted major attention in mathematics in recent years, due to many significant applications in geometry, physics and applied science. This project aims to resolve challenging problems involving Monge-Ampere type equations, by utilising new ideas and breakthroughs made by the proposer. A comprehensive regularity theory for Monge-Ampere type equations, particularly in the degenerate case, is expected to be established. Innovative cutting-edge techniques and interdisciplinary approaches are expected to be developed. Anticipated outcomes of this project include the resolution of outstanding open problems and continuing enhancement of Australian leadership and expertise in a major area of mathematics.Read moreRead less
Optimal shapes in geometry and physics: Isoperimetry in modern analysis. This project will find the best isoperimetric shapes in curved spaces: shapes that optimise geometric or analytic quantities, such as the volume enclosed by a surface of a given area, or the resonant frequency of a drum of given area. The optimal shapes lead to tools that are widely used in differential equations, geometric analysis, statistical physics, probability theory, and quantum computing. Through this work, we ....Optimal shapes in geometry and physics: Isoperimetry in modern analysis. This project will find the best isoperimetric shapes in curved spaces: shapes that optimise geometric or analytic quantities, such as the volume enclosed by a surface of a given area, or the resonant frequency of a drum of given area. The optimal shapes lead to tools that are widely used in differential equations, geometric analysis, statistical physics, probability theory, and quantum computing. Through this work, we will forge connections between the geometry of curved spaces, and the physics of operators therein. The significant benefits of this project include increasing fundamental mathematical knowledge, building capacity in Australia’s world-class geometric analysis community, and strong links with international partners.Read moreRead less
Parabolic methods for elliptic boundary value problems. This project aims to uncover new results for second order nonlinear elliptic partial differential equations via the use of uniqueness properties of solutions for related nonlinear parabolic partial differential equations. This will build on theory for fully nonlinear equations developed over the last 30 years. The project expects to generate new knowledge in the theory that will guide future research and have direct impact to applications ....Parabolic methods for elliptic boundary value problems. This project aims to uncover new results for second order nonlinear elliptic partial differential equations via the use of uniqueness properties of solutions for related nonlinear parabolic partial differential equations. This will build on theory for fully nonlinear equations developed over the last 30 years. The project expects to generate new knowledge in the theory that will guide future research and have direct impact to applications in optimal transport, geometric problems and more applied areas including image analysis and mathematical finance. The project will enhance Australia's international reputation for research in the field and train some of the next generation of mathematical analysts.Read moreRead less