In Search Of Airways Collapse - A Multimodal Device For The Diagnosis Of Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$479,786.00
Summary
Using a combination of off-the-shelf and emerging technologies we will develop a multimodal diagnostic device that will identify and characterize the points of airway collapse that occur in patients with obstructive sleep apnoea. Using this multimodal approach will allow sleep clinicians to recommend the best form of therapeutic intervention for each individual patient rather than the current strong reliance on positive pressure facemasks.
Clinical Outcomes, Safety And Incremental Cost Effectiveness Of Multi-level Airway Surgery In Patients With Moderate-severe Obstructive Sleep Apnea (OSA) Who Have Failed Medical Management
Funder
National Health and Medical Research Council
Funding Amount
$652,794.00
Summary
Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to ....Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to improved patient outcomes.Read moreRead less
Glucose is a critical fuel for living organisms and its presence in the gut triggers nerves that slow stomach emptying. However, little is known of how glucose is actually detected in the gut. We have established that sweet taste molecules of the tongue are also present in the gut, where they may detect glucose. This research will measure the expression and function of these molecules in the gut of humans and mice, and reveal key information on their potential as targets in health and disease.
Revival' in the Middle East: The Genesis of Israeli ('Modern Hebrew') - lessons for revival of no-longer spoken Australian languages. This project will enhance mutual understanding within multicultural Australia: (1) helping community leaders seeking to apply the lessons of Israeli to the revival of no-longer spoken Australian languages; (2) assisting local Jews to explore their roots and substantially improving Israeli and Hebrew teaching methodologies at universities and Jewish schools in Aust ....Revival' in the Middle East: The Genesis of Israeli ('Modern Hebrew') - lessons for revival of no-longer spoken Australian languages. This project will enhance mutual understanding within multicultural Australia: (1) helping community leaders seeking to apply the lessons of Israeli to the revival of no-longer spoken Australian languages; (2) assisting local Jews to explore their roots and substantially improving Israeli and Hebrew teaching methodologies at universities and Jewish schools in Australia. Globally, the project will enhance Australia's understanding of social, political and cultural conditions in the Middle East, by facilitating a clearer and more complex understanding of the languages and politics in the region. It will therefore make a valuable contribution to the war against terrorism, now the major threat to national security.Read moreRead less
How free is free?: word order in Australian Indigenous languages. This project aims to address the fundamental issue of how the grammatical structure of the language we speak shapes the way we plan and interpret sentences. The project will use innovative methodologies to investigate language production and comprehension in three Australian Indigenous languages that have unusually free word order, where the words in a sentence can be varied in multiple ways without changing the overall meaning. E ....How free is free?: word order in Australian Indigenous languages. This project aims to address the fundamental issue of how the grammatical structure of the language we speak shapes the way we plan and interpret sentences. The project will use innovative methodologies to investigate language production and comprehension in three Australian Indigenous languages that have unusually free word order, where the words in a sentence can be varied in multiple ways without changing the overall meaning. Expected outcomes include new knowledge of the relationship between language structure and human cognition, a deeper understanding of the grammatical structure of three Indigenous languages and how they differ from other languages, and important contributions to Indigenous language maintenance and education.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101749
Funder
Australian Research Council
Funding Amount
$379,480.00
Summary
A computational network model of the mental lexicon. Understanding a word's meaning is a challenge when learning a language and a capacity that is seriously affected in various disorders such as Alzheimer's disease, however little is known about how meaning is organised in the mental lexicon and evolves from childhood into old age. This project aims to build a detailed computational model integrating information available through the senses and structure in the language environment to derive a l ....A computational network model of the mental lexicon. Understanding a word's meaning is a challenge when learning a language and a capacity that is seriously affected in various disorders such as Alzheimer's disease, however little is known about how meaning is organised in the mental lexicon and evolves from childhood into old age. This project aims to build a detailed computational model integrating information available through the senses and structure in the language environment to derive a lexicon that covers most words people know. By distinguishing qualitative different types of meaning relations, this project will allow the prediction of the kind of information and processes required to understand words and an understanding of how this lexicon grows in childhood and declines in old age.Read moreRead less
Phonological effects on the development of inflectional morphology. This project investigates the mechanisms underlying typically developing children's variable omission of inflectional morphemes (for example, plural, past tense). The results will have significant implications for the evaluation and design of interventions for language-delayed populations where serious problems of communication persist.
Discovery Early Career Researcher Award - Grant ID: DE120102378
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
What shapes the structure of language? An experimental and computational investigation. How do people learn language so easily, and how is the structure of language shaped by our learning biases? This project attempts to answer these questions through an innovative combination of experimental and computational tools, with implications for technological development as well as educational interventions for both children and adults.