Program evaluation of the osteoarthritis awareness hub. Persons with osteoarthritis generally have poor knowledge about their disease and its appropriate management. The aim of this project is to evaluate whether improved knowledge, and management decisions of persons with osteoarthritis, can ultimately lead to improved health outcomes.
The role of SGK-1 and SGK-2 in hypertension and nephropathy in diabetes mellitus. The key objective is to define the suitability of the serum glucocorticoid regulated kinases -1 and -2 (SGK-1, -2) as novel drug discovery targets. A specific inhibitor targeting SGK-1 and -2 will be tested to determine if it reverses the enhanced sodium reabsorption and extracellular matrix production characteristic of progressive renal failure in in vitro models models of renal disease. These inhibitors present a ....The role of SGK-1 and SGK-2 in hypertension and nephropathy in diabetes mellitus. The key objective is to define the suitability of the serum glucocorticoid regulated kinases -1 and -2 (SGK-1, -2) as novel drug discovery targets. A specific inhibitor targeting SGK-1 and -2 will be tested to determine if it reverses the enhanced sodium reabsorption and extracellular matrix production characteristic of progressive renal failure in in vitro models models of renal disease. These inhibitors present an opportunity to control hypertension whilst simultaneously limiting fibrosis in the kidney. Renal failure is steadily increasing and is now the single largest health care cost to the community. These studies will provide the proof of concept required to ultimately bring this novel preventative therapy to the community.Read moreRead less
Tonal language development in Mandarin and Cantonese-speaking children with cochlear implants. Cochlear implantation in children is expanding in countries where tonal languages are spoken, despite limited evidence of the effectiveness of implant use in these settings. This project will examine the impact of implant use on children's perception of tone, their production of speech and assesses how this affects functional communication.