Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Private Wealth Accumulation, Wealth Distribution, and Social Welfare Reform in Urban China. During the 1990s, when the Chinese urban labour market and social security reforms accelerated, average urban household wealth increased more than three fold and the distribution of wealth widened. We will document this significant change and examine its relationship to past and future social welfare reform. This project will:
· Be the first study of wealth accumulation and distribution in China over th ....Private Wealth Accumulation, Wealth Distribution, and Social Welfare Reform in Urban China. During the 1990s, when the Chinese urban labour market and social security reforms accelerated, average urban household wealth increased more than three fold and the distribution of wealth widened. We will document this significant change and examine its relationship to past and future social welfare reform. This project will:
· Be the first study of wealth accumulation and distribution in China over the 1990s.
· Add to our knowledge of the interrelationship between wealth accumulation, distribution and political power during economic transition.
· Contribute to a better design of a new social welfare system.
· Develop lessons and policy implications that will be broadly applicable to most transitional and developing economies.
The project will produce at least seven journal articles and one book.
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Mobility Shocks: Understanding disruptions to Australian migration. This Fellowship aims to generate new knowledge about the impacts of the Covid-19 pandemic on human migration and mobility, in order to advance understanding of major disruptive changes to population movement more broadly. Fellowship outcomes will include designing innovative geospatial research methods, linking and analysing cutting-edge datasets, and building cross-sector collaborations, in order to develop a new theory of ‘Mob ....Mobility Shocks: Understanding disruptions to Australian migration. This Fellowship aims to generate new knowledge about the impacts of the Covid-19 pandemic on human migration and mobility, in order to advance understanding of major disruptive changes to population movement more broadly. Fellowship outcomes will include designing innovative geospatial research methods, linking and analysing cutting-edge datasets, and building cross-sector collaborations, in order to develop a new theory of ‘Mobility Shocks’. This will benefit Australia and its migration partners with new ideas, tools, evidence and expertise to help scholars, policy makers and practitioners to understand, anticipate, and manage future disruptive changes to human migration and mobility in the Australian context and beyond.Read moreRead less
Ocular Motility In Autism And Asperger S Disorder: Dissociation Of Motor Deficits.
Funder
National Health and Medical Research Council
Funding Amount
$131,235.00
Summary
We will use ocular motor technology to investigate motor dysfunction in autism and Asperger's disorder, to advance our understanding of the neurobiological bases of these disorders. This will help clarify whether neural networks are differentially disrupted in these disorders, as our previous clinical research suggests. This dissociation and the subsequent development of an ocular motor clincal screen may improve diagnosis, and potentially treatment, of these devastating conditions.
The basis of conscious thought. The science and philosophy of consciousness has made much progress in recent years, and the study of conscious thought is the next frontier. The project will place Australian research on the leading edge of this area. An international network of researchers will analyse both the neurobiological basis and the subjective experience of conscious thought, yielding a unified account of conscious thinking from the first-person and third-person perspectives. The resultin ....The basis of conscious thought. The science and philosophy of consciousness has made much progress in recent years, and the study of conscious thought is the next frontier. The project will place Australian research on the leading edge of this area. An international network of researchers will analyse both the neurobiological basis and the subjective experience of conscious thought, yielding a unified account of conscious thinking from the first-person and third-person perspectives. The resulting account will illuminate the nature of human thinking and reasoning, and will be applied to the detection of consciousness in post-coma patients.Read moreRead less
Sustaining India's economic transformation: challenges, prospects and implications for Australia and the Pacific region. India's emergence from economic stagnation is beginning to have a profound impact on the world economy, including Australia. This project aims to investigate the sources of India's growth and the reforms needed to ensure that growth generates reductions in poverty and ensures equity and political stability.
Lead-free oxide perovskites for highly efficient solar cells. This project aims to develop nanostructured lead-free oxide perovskites for solar energy applications. These materials will strengthen the future of photovoltaic technology by overcoming bandgap voltage limitations and toxicity/stability issues that plague conventional silicon-based and emerging halide perovskite-based solar cells. This project is expected to advance the rational design of solar cells based on oxide perovskites, which ....Lead-free oxide perovskites for highly efficient solar cells. This project aims to develop nanostructured lead-free oxide perovskites for solar energy applications. These materials will strengthen the future of photovoltaic technology by overcoming bandgap voltage limitations and toxicity/stability issues that plague conventional silicon-based and emerging halide perovskite-based solar cells. This project is expected to advance the rational design of solar cells based on oxide perovskites, which are efficient, high output voltage, environmentally friendly photovoltaic technology Success of the proposed programme paves the way to promote photovoltaic technology as a mainstream power generation source and a significant contributor to achieving energy, environmental and economic goals.Read moreRead less
Motor Functioning In Autism And Asperger's Disorder: Furthering Current Neurobehavioural And Clinical Definitions
Funder
National Health and Medical Research Council
Funding Amount
$354,932.00
Summary
While it is well known that autism and Asperger's disorder are associated with social, communicative, and behavioural symptoms, it is less well known that affected individuals also have considerable movement and coordination difficulties. For example, these children often have problems with hand writing, walking, hopping, skipping, catching, and running. These skills are very important for success at school; for example, if children are unable to participate in school sports they often feel isol ....While it is well known that autism and Asperger's disorder are associated with social, communicative, and behavioural symptoms, it is less well known that affected individuals also have considerable movement and coordination difficulties. For example, these children often have problems with hand writing, walking, hopping, skipping, catching, and running. These skills are very important for success at school; for example, if children are unable to participate in school sports they often feel isolated and rejected from the peer group. Also, hand writing problems have a significant impact on children's academic performance. Our previous research has suggested that there may be particular patterns of motor problems that characterise individuals with autism and Asperger's disorder. Our proposed research aims to use the kinds of 3D motion analysis technology used in the movie industry to capture exactly how people affected by these conditions move and respond to the environment. This study will enable us to highlight particular parts of the brain-motor circuitry that are affected by these disorders and will also enable us to more clearly distinguish how autism is different from Asperger's disorder. Ultimately, it is hoped that our motor investigations will lead to improved assessment and interventions for these disorders.Read moreRead less
Regulation Of Ribosomal RNA Gene Chromatin During Malignant Transformation.
Funder
National Health and Medical Research Council
Funding Amount
$882,486.00
Summary
The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.