Understanding How Second Primary Malignancies Arise Following Multiple Myeloma Therapy
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Multiple myeloma is a cancer of white blood cells. Chemotherapy and new drugs that target cancer cells are the most effective therapies for multiple myeloma. However, these drugs also increase the chance of developing a secondary cancer that is different to the initial cancer. Little is known about how these cancers arise. I aim to find out how current therapies cause secondary cancers; with the hope of finding alternative therapies for multiple myeloma that do not cause secondary cancers.
Examining The Importance Of DNA Damage Repair For Oocyte Quality, Female Fertility And Offspring Health
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
As women age, the quality of their eggs decline and their chance of having a healthy baby plummets. The accumulation of DNA damage within the egg, and the reduced ability to repair this damage, may be one cause of compromised reproductive success in older women. This project will investigate the ability of eggs to repair DNA damage during maternal aging and will explore the importance of DNA repair to fertility and the transmission of high quality genetic material to their offspring.