Deciphering The Role Of Atypical DNA Methylation In Neuronal Genome Regulation And Neurological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$773,484.00
Summary
This research will use a combination of genomic, biochemical and functional genomics approaches to investigate the role of the atypical mCH form of DNA methylation in neuronal genome regulation and function, and provide new insights into the role of the epigenome in healthy brain function and neural pathologies.
EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347553
Funder
Australian Research Council
Funding Amount
$175,000.00
Summary
Smart Equipment for Remote Monitoring of Isolated and Mobile Infrastructure. The partners' research involves the collection and assessment of data to determine the condition, maintenance strategies and risk of failure of plant in diverse areas such as transport, cargo and packaging, mining and power. Recent advances in data processing, computing and telemetry mean that it is now possible to actually install small and rugged data acquisition equipment on remote infrastructure or mobile plant. T ....Smart Equipment for Remote Monitoring of Isolated and Mobile Infrastructure. The partners' research involves the collection and assessment of data to determine the condition, maintenance strategies and risk of failure of plant in diverse areas such as transport, cargo and packaging, mining and power. Recent advances in data processing, computing and telemetry mean that it is now possible to actually install small and rugged data acquisition equipment on remote infrastructure or mobile plant. This equipment can acquire, condition and process the signals and use wireless telemetry to transmit the data for remote assessment. The proposed infrastructure will enable the partners' research to be extended to these challenging applications.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC160100025
Funder
Australian Research Council
Funding Amount
$2,259,000.00
Summary
ARC Training Centre in Food Safety in the Fresh Produce Industry. ARC Training Centre in Food Safety in the Fresh Produce Industry. This centre aims to create an innovation platform of food safety researchers and industry personnel who can significantly advance the safety of fruit and vegetables in Australia. The intended outcomes are safer food, leading to enhanced health and wellbeing; industry growth in the food/agribusiness sector; enhanced trust and international reputation; and increased a ....ARC Training Centre in Food Safety in the Fresh Produce Industry. ARC Training Centre in Food Safety in the Fresh Produce Industry. This centre aims to create an innovation platform of food safety researchers and industry personnel who can significantly advance the safety of fruit and vegetables in Australia. The intended outcomes are safer food, leading to enhanced health and wellbeing; industry growth in the food/agribusiness sector; enhanced trust and international reputation; and increased access to growing export markets. Intended benefits to industry are ready-to-use technologies for strengthened food safety, and a new generation of highly-skilled food safety scientists with experience in conducting industry-focused research.Read moreRead less
Functional Renewable Plastics: Developing Novel Polysaccharide, Protein and Natural Polyester Based Polymer Nanocomposites. Biopolymer based plastics (eg starch and proteins from plants; polylactic acid from wastes) are made from renewable sources and are readily biodegradable, making them good substitutes for synthetic plastics for uses like packaging and agricultural film.
Some biopolymer plastics properties (eg water migration barrier, strength) are not as high as synthetic plastics. Creat ....Functional Renewable Plastics: Developing Novel Polysaccharide, Protein and Natural Polyester Based Polymer Nanocomposites. Biopolymer based plastics (eg starch and proteins from plants; polylactic acid from wastes) are made from renewable sources and are readily biodegradable, making them good substitutes for synthetic plastics for uses like packaging and agricultural film.
Some biopolymer plastics properties (eg water migration barrier, strength) are not as high as synthetic plastics. Creating nano-biocomposites (biopolymer plastics mixed with low levels of nano particles) will improve the properties of biopolymer plastics, giving novel materials that can be substituted for synthetic plastics in a wider range of applications.
These products will reduce our environmental impact, and also create economic benefits from novel, high-value nano-biocomposites.Read moreRead less
Carbon fibre thermoplastics as next-generation carbon fibre composites. By combining sizing, chemical grafting, and nano-reinforcement strategies, this project develops chemically and thermally robust thermoplastic interfacial sizing for carbon fiber/thermoplastic composites for rapid manufacturing. Thermostamped carbon fiber/thermoplastic composite prototypes will be used to verify the sizing. In order to demonstrate industrial viability, recyclability and reprocessability analyses will be cond ....Carbon fibre thermoplastics as next-generation carbon fibre composites. By combining sizing, chemical grafting, and nano-reinforcement strategies, this project develops chemically and thermally robust thermoplastic interfacial sizing for carbon fiber/thermoplastic composites for rapid manufacturing. Thermostamped carbon fiber/thermoplastic composite prototypes will be used to verify the sizing. In order to demonstrate industrial viability, recyclability and reprocessability analyses will be conducted. This sizing method can enable high-performance thermoplastic composites in nonaerospace applications with its atomistic level modelling and comprehensive characterisation routine. A key objective of this study is to produce sustainably manufactured composite materials that are also commercially relevant.Read moreRead less
Biomass-derived Carbon Dots Enable Flexible, On-Demand Hydrogen Delivery . Methanol is a promising liquid hydrogen carrier for long distance H2 transportation and exportation, because it is rich in hydrogen content, cheap, recyclable between methanol-formaldehyde and easier to manufacture from renewable resources including biomass waste. The critical bottleneck in adopting methanol as the carrier is the demanding dehydrogenation process. The project aims to create a new class of photocatalyst ba ....Biomass-derived Carbon Dots Enable Flexible, On-Demand Hydrogen Delivery . Methanol is a promising liquid hydrogen carrier for long distance H2 transportation and exportation, because it is rich in hydrogen content, cheap, recyclable between methanol-formaldehyde and easier to manufacture from renewable resources including biomass waste. The critical bottleneck in adopting methanol as the carrier is the demanding dehydrogenation process. The project aims to create a new class of photocatalyst based on biomass-derived carbon nanodots grown on transition metal (di)chalcogenide nanosheets that can effectively enable a light-controlled methanol H2 release of desired quantity. The key outcomes will be a new class of photocatalysts and flexible, on-demand hydrogen delivery technology for liquid hydrogen carriers.Read moreRead less
Reducing the health & economic burden of Campylobacter using a live vaccine. The aim of the project is to develop a vaccine to reduce Campylobacter bacteria in chickens. Campylobacters cause disease in both poultry and humans. Poultry products are the most common source of human infections. By reducing Campylobacter in poultry, the transfer to humans will be reduced. The expected outcomes arising from this work will be a reduction of the economic burden of poultry losses, in an Australian indust ....Reducing the health & economic burden of Campylobacter using a live vaccine. The aim of the project is to develop a vaccine to reduce Campylobacter bacteria in chickens. Campylobacters cause disease in both poultry and humans. Poultry products are the most common source of human infections. By reducing Campylobacter in poultry, the transfer to humans will be reduced. The expected outcomes arising from this work will be a reduction of the economic burden of poultry losses, in an Australian industry valued at $2.8 billion/year, and an improvement in food safety, thus helping to reduce the burden of foodborne illness, estimated to be $1.2 billion dollars/year. This project is, therefore, poised to benefit the Australian economy, specifically primary producers and the general public, by targeted vaccination of poultry.Read moreRead less