The Market for Technology in Australia. Over the last 5 years, formalised markets for technology have accelerated in the US. However, there is no recognised formal market in Australia. Results from our primary data collection and analysis will highlight whether deficiencies in the market for technology are creating obstacles for the commercialisation of Australian technology. This is a particularly important issue for Australia given our relative isolation arising from geographical distance and ....The Market for Technology in Australia. Over the last 5 years, formalised markets for technology have accelerated in the US. However, there is no recognised formal market in Australia. Results from our primary data collection and analysis will highlight whether deficiencies in the market for technology are creating obstacles for the commercialisation of Australian technology. This is a particularly important issue for Australia given our relative isolation arising from geographical distance and lack of attachment to a major trading bloc such as the EU or NAFTA.Read moreRead less
The efficiency of the global patent system. This project will be the first study in the world to combine a new international patent database with more in-depth local information from Australia, Japan, US, Europe and Chinese Asia (China, Taiwan). The patent system should be globally consistent; simple and cost effective to use; parsimonious in the grant of monopoly rights; and provide a level playing field for all inventors. Existing empirical evidence indicates that the patent system is current ....The efficiency of the global patent system. This project will be the first study in the world to combine a new international patent database with more in-depth local information from Australia, Japan, US, Europe and Chinese Asia (China, Taiwan). The patent system should be globally consistent; simple and cost effective to use; parsimonious in the grant of monopoly rights; and provide a level playing field for all inventors. Existing empirical evidence indicates that the patent system is currently inefficient and this has negative effects on our Research and Development sector.Read moreRead less
The Determinants of Australia's Productivity Performance. Productivity growth is the key to increasing prosperity for all Australians. The scholar will survey the theoretical and empirical literature pertinent to explaining trends and cycles in the productivity of the Australian economy over the past thirty years. The scholar will then select specific areas for focused research which will lead to academic papers and the submission of a PhD thesis.
Tackling the Tough Problems in Productivity Measurement: Infrastructure, Services and R&D. Productivity is seen as a main driver of economic growth and welfare improvements. Productivity indexes are used in a variety of policy contexts, in particular in determining the effectiveness (or otherwise) of government policies. Most industrialized countries have productivity accounts, but measurement problems persist and may even be more problematic in the future given an expansion in new goods and ser ....Tackling the Tough Problems in Productivity Measurement: Infrastructure, Services and R&D. Productivity is seen as a main driver of economic growth and welfare improvements. Productivity indexes are used in a variety of policy contexts, in particular in determining the effectiveness (or otherwise) of government policies. Most industrialized countries have productivity accounts, but measurement problems persist and may even be more problematic in the future given an expansion in new goods and services. Improved productivity measurement and an improved understanding of its sources can inform aggregate and regional policy. The project includes collaboration with the Australian Bureau of Statistics and the Productivity Commission, with the participation of the Reserve Bank of Australia.Read moreRead less
Special Research Initiatives - Grant ID: SR0354852
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Sustainable Regions for a Competitive Australia. How can metropolitan, rural and remote regions balance economic and job growth, with environmental and social sustainability? This Initiative establishes a Network of researchers to work collaboratively on questions of environmental best practice, community development, regional governance, labour markets, economic development and technology transfer. The Network's vision is to find ways to use existing and future research to help make Australia ....Sustainable Regions for a Competitive Australia. How can metropolitan, rural and remote regions balance economic and job growth, with environmental and social sustainability? This Initiative establishes a Network of researchers to work collaboratively on questions of environmental best practice, community development, regional governance, labour markets, economic development and technology transfer. The Network's vision is to find ways to use existing and future research to help make Australia's regions more competitive on world markets and more environmentally sustainable, and to help build stronger regional communities. The Network cuts across traditional discipline boundaries to find integrated solutions to the real problems confronting Australian regions.Read moreRead less
Climate Change, Industrial Structure and the Knowledge Economy: Key Issues for an Effective Response on Greenhouse Gases. The objectives of this project are to undertake a major, long term study of the impact of global structural change on greenhouse gas emissions and on climate change, and to develop a detailed knowledge base concerning trade in embodied emissions. It is hoped that the knowledge generated will both inform global responses to this vital problem and contribute to the continuing d ....Climate Change, Industrial Structure and the Knowledge Economy: Key Issues for an Effective Response on Greenhouse Gases. The objectives of this project are to undertake a major, long term study of the impact of global structural change on greenhouse gas emissions and on climate change, and to develop a detailed knowledge base concerning trade in embodied emissions. It is hoped that the knowledge generated will both inform global responses to this vital problem and contribute to the continuing development of effective responses within Australia. The output - a book and many papers - will be directed in part to contribute to the IPCC's Fourth Assessment Report.Read moreRead less
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less
Apoptosis And Stem Cells In Cancer Development And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$22,852,198.00
Summary
To improve cancer therapy, we are studying two cancer hallmarks: enhanced cell survival and stem cell-like behaviour. As we discovered, cell death is often blocked in cancer cells. Hence, we are attempting to develop drugs that flip the natural ‘cell death switch’. Stem cells are rare cells that generate entire tissues, as we showed for the breast. Certain cancers may be driven by ‘rogue’ stem cells. If so, eradication of these rare cells within the bulk tumour may require novel therapies.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Mechanisms Of Glucocorticoid Resistance In Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$547,970.00
Summary
Glucocorticoids are extremely active drugs used in the treatment of childhood acute lymphoblastic leukaemia (ALL), yet a proportion of patients respond poorly to therapy and exhibit resistance at relapse. Clinically relevant mechanisms of glucocorticoid resistance are poorly understood, principally due to lack of appropriate experimental models. This project will reveal novel mechanisms of drug resistance in childhood leukaemia and lead to novel therapeutic strategies to improve outcome.