The Economic And Social Impacts Of Genetic Sequencing For Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$1,263,576.00
Summary
In this project we will quantify the social and financial costs to families of severe intellectual disability that is genetic in origin. We will assess these impacts in terms of poorer carer health, relationship breakdown, lost income and risk of poverty, as well as increased dependence on government, particularly on welfare payments, and reduced personal income tax paid. We will then determine the extent to which modern clinical genomics can contribute to ameliorating these impacts.
The Get Healthy Coaching Service To Reduce The Burden Of Low Back Pain: Effectiveness, Cost Effectiveness, And Scalability
Funder
National Health and Medical Research Council
Funding Amount
$1,108,389.00
Summary
Many improve after discharge from treatment for low back pain (LBP), however some experience worsening symptoms and seek costly additional health care. Get Healthy Service® is a free phone-based health coaching service that supports people to remain physically active, however there is no co-ordinated referral pathway to the service. We will test the effectiveness, cost-effectiveness and scalability of a discharge support system linking chronic LBP patients to the Get Healthy Service®.
An International Comparison of Corporate Financial Policy. Our research contributes to the finance discipline, corporate decision making and public policy. Existing empirical literature provides managers with insights on the impact of firm characteristics on corporate financial decisions. However, beyond suggesting that well-functioning banks, equity and bond markets are an integral part of corporate financing, no insight is provided as to the role played by the public policy, legal structures a ....An International Comparison of Corporate Financial Policy. Our research contributes to the finance discipline, corporate decision making and public policy. Existing empirical literature provides managers with insights on the impact of firm characteristics on corporate financial decisions. However, beyond suggesting that well-functioning banks, equity and bond markets are an integral part of corporate financing, no insight is provided as to the role played by the public policy, legal structures and the suppliers of capital. In a market such as Australia, where superannuation is a large and increasing part of corporate funding, this is a glaring omission. This study seeks to examine the impact of public policy, legal and institutional structures on these financial choices.Read moreRead less
Development Of A New High Throughput Screen For Drug Binding To HERG K+ Channels
Funder
National Health and Medical Research Council
Funding Amount
$351,320.00
Summary
Inadvertent drug block of hERG, a potassium channel in the heart, can cause cardiac arrhythmias and sudden cardiac death. Screening for hERG toxicity has become a major hurdle for development of new drugs. We will use a mutant hERG protein that has enhanced drug binding to develop a high throughput test for hERG toxicity. Identification of dangerous drugs early in the drug discovery process will save the pharmaceutical industry millions of dollars in the costs of brining new drugs to market.
Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
An economic analysis of multi-period reform programs. This project aims to use a mechanism design approach to study multi-period reform programs and their use in the transition from status quo institutions. The project intends to shed light on the difficulties of introducing efficiency enhancing long-term policies. Expected outcomes include theoretical models that incorporate adjustment costs, common values, and complicated status quo institutions into models of economic reform from a mechanism ....An economic analysis of multi-period reform programs. This project aims to use a mechanism design approach to study multi-period reform programs and their use in the transition from status quo institutions. The project intends to shed light on the difficulties of introducing efficiency enhancing long-term policies. Expected outcomes include theoretical models that incorporate adjustment costs, common values, and complicated status quo institutions into models of economic reform from a mechanism design perspective as well as optimal dynamic reform policies in the presence of these frictions, focusing attention in the trade-off between static efficiency and dynamic welfare gains. Intended benefits include insights that are wildly applicable to the provision of public infrastructure and management of public resources.Read moreRead less
Chief executive officer pay, incentives, talent and risk-taking: Excessive pay, regulation and the global financial crisis. The Prime Minister has requested the regulators, APRA and Treasury, to come up with rules that would prevent a repeat of the trillion dollar bailouts and guarantees to the financial sector and banks at risk of failure. Excessive pay and risk-taking by bank executives shoulder made the blame for the global crisis that has already cost Australian investors and taxpayers a siz ....Chief executive officer pay, incentives, talent and risk-taking: Excessive pay, regulation and the global financial crisis. The Prime Minister has requested the regulators, APRA and Treasury, to come up with rules that would prevent a repeat of the trillion dollar bailouts and guarantees to the financial sector and banks at risk of failure. Excessive pay and risk-taking by bank executives shoulder made the blame for the global crisis that has already cost Australian investors and taxpayers a sizeable portion of the nation's wealth. The project will greatly assist the regulators in this task. It will also identify compensation practices that reward good long-term performance without excessive pay. This could dramatically raise the performance of Australian companies and ameliorate the problem of dissatisfied investors and taxpayers.Read moreRead less
Glycine Transporters regulate the concentration of glycine in the spinal cord and brain. It has been suggested that elevating glycine levels in these regions may be useful in treating pain and schizophrenia. This project will provide the basis for the development of new glycine transport inhibitors that may be used to treat these conditions.
Glucocorticoid Resistance In Paediatric Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$394,721.00
Summary
Glucocorticoids are among the most effective drugs used in the treatment of many haematological malignancies, including leukaemia, lymphoma and multiple myeloma. However, the development of tumour cell resistance to these drugs remains a significant problem, and clinically relevant mechanisms of glucocorticoid resistance remain poorly understood. This project aims to define mechanisms of resistance to glucocorticoids and develop new drugs to reverse resistance.
Translational Research Initiatives In Acute Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
Recent research has focussed on molecular characterisation of high-risk acute leukaemia subtypes. This proposal will combine the power of genomic analysis, global analysis of protein kinases and stringent preclinical drug testing in order to improve the treatment of these high-risk acute leukaemia subtypes. Several innovative and interrelated projects within this Program will utilise a unique and clinically relevant experimental model to achieve their goals.