Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Towards Generalisable and Unbiased Dynamic Recommender Systems. This project aims to develop the foundations, including models, methodology, and algorithms for building generalisable and unbiased dynamic recommender systems to facilitate intelligent decision-making, prompt contextualised and personalised strategic plans, and support context-aware action recourse. To ensure that fundamental principles, such as fairness and transparency, are respected, a set of algorithms and techniques are propos ....Towards Generalisable and Unbiased Dynamic Recommender Systems. This project aims to develop the foundations, including models, methodology, and algorithms for building generalisable and unbiased dynamic recommender systems to facilitate intelligent decision-making, prompt contextualised and personalised strategic plans, and support context-aware action recourse. To ensure that fundamental principles, such as fairness and transparency, are respected, a set of algorithms and techniques are proposed to develop recommender systems in a more responsible manner. The result of this project will not only maintain Australia's leadership in this frontier research area, but also serve as an excellent vehicle for the education and training of Australia's next generation of scholars and engineers.Read moreRead less
What is safe about “safe migration”? Migration management in the Mekong. The project seeks to examine the claims that new policy models make about assuring the safety of labour migrants. What is safe about safe migration? Regulation of labour migrants is a central policy concern in Asia, Australia and elsewhere. In an attempt to address anti-trafficking, several donors, United Nations agencies, nongovernment organisations and Governments have launched ‘safe migration’ programs which, rather than ....What is safe about “safe migration”? Migration management in the Mekong. The project seeks to examine the claims that new policy models make about assuring the safety of labour migrants. What is safe about safe migration? Regulation of labour migrants is a central policy concern in Asia, Australia and elsewhere. In an attempt to address anti-trafficking, several donors, United Nations agencies, nongovernment organisations and Governments have launched ‘safe migration’ programs which, rather than focusing solely on the legal status of migrants, seek to develop mechanisms (eg hotline numbers) to assure their safety. This research examines the claims of safety that this shift from anti-trafficking to safe migration has engendered, and whether and in what terms labour migrants might be consequently safer’. Project results may inform aid programs and government policies.Read moreRead less
Intercultural understanding in primary and secondary schools. What facilitates or impedes intercultural understanding in children, adolescents and schools? How can this be addressed? How can we know what makes a difference? This project answers these questions at the individual, school and national level using a novel cultural systems approach and methodological and technological innovations.
Improving wellbeing through student participation at school. Current evidence suggests child and youth participation in matters affecting their lives has many benefits, but little is known about how this is perceived and practiced in education. This research aims to improve knowledge about processes and outcomes of student participation at school, particularly in relation to improving wellbeing. The project is timely and significant because recent reforms in education now require a greater empha ....Improving wellbeing through student participation at school. Current evidence suggests child and youth participation in matters affecting their lives has many benefits, but little is known about how this is perceived and practiced in education. This research aims to improve knowledge about processes and outcomes of student participation at school, particularly in relation to improving wellbeing. The project is timely and significant because recent reforms in education now require a greater emphasis on engaging students more directly in decisions about their education, including those with special needs. Schools urgently require knowledge about the key elements of participation that impact on wellbeing and a tool for measuring and monitoring their performance in facilitating these elements.Read moreRead less
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Building on rural knowledges to unlock the potential of rural students. This project aims to advance understanding of the distinctive knowledges that rural students bring to school and develop teaching practices that build on these rural knowledges to unlock the potential of this significant student population. The project involves collaborating with rural primary schools, teachers, students and communities to identify rural knowledges, study classroom practices in detail, and develop sustainabl ....Building on rural knowledges to unlock the potential of rural students. This project aims to advance understanding of the distinctive knowledges that rural students bring to school and develop teaching practices that build on these rural knowledges to unlock the potential of this significant student population. The project involves collaborating with rural primary schools, teachers, students and communities to identify rural knowledges, study classroom practices in detail, and develop sustainable teaching practices that help students connect rural knowledges and school knowledge. Expected outcomes include a framework of place-based teaching practices and resources that will benefit rural schooling, teacher education, and the education of communities crucial to the nation’s future wealth and welfare.Read moreRead less
Transitions to adulthood among young people in migrant families in Australia and Canada: A comparative study. Canada and Australia have had the world's highest immigration rates in recent decades. Central to the success of an immigration programme is the level of integration on immigrants themselves but, more importantly, their children. Australian research has led the world in this field. However, there is much to be gained for the mutual benefit of both countries through comparative research u ....Transitions to adulthood among young people in migrant families in Australia and Canada: A comparative study. Canada and Australia have had the world's highest immigration rates in recent decades. Central to the success of an immigration programme is the level of integration on immigrants themselves but, more importantly, their children. Australian research has led the world in this field. However, there is much to be gained for the mutual benefit of both countries through comparative research using a common framework. More broadly, as demography takes on much greater significance with population aging, there is much to be gained through international cooperation between ANU Demography and Canada's leading centre for demography, the University of Montreal.Read moreRead less
Heparin-induced Thrombocytopenia And Thrombosis: Better Understanding Of Pathogenesis And Improving Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$653,137.00
Summary
Heparin, a widely used drug, can cause an adverse effect which results in a fall of the platelet count and the development of serious thrombosis. This drug complication is mediated by an immune mechanism. This proposal aims to provide a better understanding of the disease mechanism. It also aims to develop a new test that will improve the diagnosis, and to produce a novel drug that will effectively suppress the immune reaction and improve the treatment.