Alcohol And Other Drug Treatment Funding, Purchasing And Workforce: Empirical Analyses To Inform Policy
Funder
National Health and Medical Research Council
Funding Amount
$473,865.00
Summary
Alcohol and drug treatment works: it improves health and reduces the social impact of alcohol and drug use. The treatment itself is not, however, the only variable that impacts on whether health outcomes are improved. The way in which governments fund, purchase and structure the treatment service system is also important. This study will empirically test the relationship between treatment outcome and the structures that governments put in place, providing new evidence to inform decision-making.
TB is a global public health problem, responsible for the deaths of 2 million children and young adults annually. Drug resistant strains of TB are emerging and pose a threat even in countries where TB is well controlled, such as Australia. Research undertaken in this CRE will translate into improved treatments, diagnostics and strategies to prevent transmission. The CRE will build capacity for research on TB in our region and provide a legal framework to support public health policy.
Tracking The Impact Of Drug Regulatory Actions: Consumer Health Outcomes, Risk-benefit Issues And Policy Framework.
Funder
National Health and Medical Research Council
Funding Amount
$439,324.00
Summary
This study will explore what happens in the community when a medicine is withdrawn from the market or discredited due to safety concerns. It will examine the impacts of two recent cases of medicine withdrawal or serious long-term safety concern, on a large cohort of women with high utilisation rates who were monitored during the time the medicines were discredited. The study will be an important guide to future regulatory, media and provider responses when medicines are discredited.
Development Of A New High Throughput Screen For Drug Binding To HERG K+ Channels
Funder
National Health and Medical Research Council
Funding Amount
$351,320.00
Summary
Inadvertent drug block of hERG, a potassium channel in the heart, can cause cardiac arrhythmias and sudden cardiac death. Screening for hERG toxicity has become a major hurdle for development of new drugs. We will use a mutant hERG protein that has enhanced drug binding to develop a high throughput test for hERG toxicity. Identification of dangerous drugs early in the drug discovery process will save the pharmaceutical industry millions of dollars in the costs of brining new drugs to market.
Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Assessing the national productivity impacts of chronic ill health. The project aims to address one of the biggest gaps in health and productivity research by designing a novel composite national metric that will rank lost productivity due to chronic illness The project brings together tax/transfer modelling, health modelling and epidemiological modelling specialists to develop a highly innovative microsimulation model: Health&WorkMOD to then quantify the costs of health-related productivity loss ....Assessing the national productivity impacts of chronic ill health. The project aims to address one of the biggest gaps in health and productivity research by designing a novel composite national metric that will rank lost productivity due to chronic illness The project brings together tax/transfer modelling, health modelling and epidemiological modelling specialists to develop a highly innovative microsimulation model: Health&WorkMOD to then quantify the costs of health-related productivity loss. The proposed model, an international first, will be a powerful tool to comprehensively model the cost impacts of illness and simulate policy options related to health and productivity. This will provide answers to critical policy questions for government with potential significant economic benefits.Read moreRead less
Understanding recent Australian trends in alcohol consumption and harms. This project aims to provide critical insight into recent trends in alcohol consumption and related harm in Australia. Many indicators of harm from alcohol have increased dramatically in the past decade, while drinking behaviours appear largely unchanged. This project aims to investigate two potential explanations for these trends: that apparent increases in rates of alcohol-related harm are driven by operational or adminis ....Understanding recent Australian trends in alcohol consumption and harms. This project aims to provide critical insight into recent trends in alcohol consumption and related harm in Australia. Many indicators of harm from alcohol have increased dramatically in the past decade, while drinking behaviours appear largely unchanged. This project aims to investigate two potential explanations for these trends: that apparent increases in rates of alcohol-related harm are driven by operational or administrative practices rather than by increases in actual harm; and that stable per-capita consumption data obscures divergent drinking behaviours, with increases among heavy drinkers driving increasing harm rates. The project aims to inform alcohol policy debates, which rely on robust trend data.Read moreRead less
Enhancing the Technology Transfer Capability of Australian Univerities. This project aims to assist in achieving enhanced University capability in technology transfer which is regarded by government as cruicial to improving national innovation performance. I seeks to identify the determinants of effective technology transfer and provide in-depth understanding of the social process involved in transferring both inventions and associated scientific knowledge from universities to corporationss. Emp ....Enhancing the Technology Transfer Capability of Australian Univerities. This project aims to assist in achieving enhanced University capability in technology transfer which is regarded by government as cruicial to improving national innovation performance. I seeks to identify the determinants of effective technology transfer and provide in-depth understanding of the social process involved in transferring both inventions and associated scientific knowledge from universities to corporationss. Employing a contingent effectiveness model, the research will focus on the characteristics of the transfer agent, the transfer recipient, the transfer medium, the transfer object and the demand environment. Results and recommended strategies will be communicated to university and industry managers and government officials.Read moreRead less
Glycine Transporters regulate the concentration of glycine in the spinal cord and brain. It has been suggested that elevating glycine levels in these regions may be useful in treating pain and schizophrenia. This project will provide the basis for the development of new glycine transport inhibitors that may be used to treat these conditions.
Glucocorticoid Resistance In Paediatric Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$394,721.00
Summary
Glucocorticoids are among the most effective drugs used in the treatment of many haematological malignancies, including leukaemia, lymphoma and multiple myeloma. However, the development of tumour cell resistance to these drugs remains a significant problem, and clinically relevant mechanisms of glucocorticoid resistance remain poorly understood. This project aims to define mechanisms of resistance to glucocorticoids and develop new drugs to reverse resistance.