Predicting Drug-drug Interactions Due To Tyrosine Kinase Inhibitors: Inhibition Of Drug Metabolising Enzymes And Transporters
Funder
National Health and Medical Research Council
Funding Amount
$535,495.00
Summary
Tyrosine kinase inhibitors (TKIs) are a new class of anticancer agents. Cancer patients typically receive multiple drugs, for the treatment of cancer and other diseases, increasing the probability of interactions between coadministered drugs. Despite the widespread use of TKIs, their potential to cause drug interactions is poorly understood. Using novel in vitro approaches, this project will identify drug interactions precipitated by TKIs thereby improving drug efficacy and patient safety.
A Novel Metabolic Role For UDP Glycosyltransferase 8 (UGT8)
Funder
National Health and Medical Research Council
Funding Amount
$419,144.00
Summary
The UDP glycosyltransferases (UGTs) are a family of enzymes that remove drugs and toxins from the human body as well as control levels of naturally produced molecules such as bile acids and hormones. We found that a new member of this family called UGT8 processes bile acids in the kidney and intestine and can affect how bile acids act to regulate metabolism. Our studies uncover new roles for bile acids in liver, kidney and gut health and in metabolic disorders such as diabetes and obesity.
Structure And Function Of Antimicrobial Therapies And Their Interaction With Upper Respiratory Biofilms
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Bacterial infections of the upper respiratory tract are a major public health problem affecting millions of Australians. Commonly prescribed antibiotics are often not able to eradicate all bacteria as the bacteria often reside in a protective, self-produced gel-like matrix known as biofilm. This Fellowship aims to unravel the interaction of modern anti-infective therapeutics with the biofilm for the development of the next generation of safe and efficacious anti-biofilm strategies.
The relocation tool kit: A guide for implementing relocation policies that enhance residents health and well-being and social inclusion. The project aims to identify and rank in order of importance key factors affecting the health, wellbeing and social inclusion of disadvantaged groups when they are rehoused as part of housing upgrading projects. This information will increase our understanding of the impacts of changes to housing quality, social networks (familial, friends), neighbourhood envir ....The relocation tool kit: A guide for implementing relocation policies that enhance residents health and well-being and social inclusion. The project aims to identify and rank in order of importance key factors affecting the health, wellbeing and social inclusion of disadvantaged groups when they are rehoused as part of housing upgrading projects. This information will increase our understanding of the impacts of changes to housing quality, social networks (familial, friends), neighbourhood environments (reputation, socio-economic mix, services) and project management models (resident involvement, community consultation processes). The expected outcome is a tool kit for policy makers to form innovative responses to promote health and well being and social inclusion amongst the most disadvantaged groups in Australian society.Read moreRead less
Emerging from the shadows: the evaluation of intervention strategies to reduce social isolation amongst the aged. Social isolation imposes a high cost on affected individuals and the community at large. This project will determine what interventions work in addressing social isolation amongst the older population.
The rise of the consumer: engagement of older people with consumer directed care. Australia is adopting a new model of care for older Australians - consumer directed care. This project will provide the evidence needed by governments and service providers to create the most effective and supportive system.
Problem gambling: development and application of a new conceptual framework for aetiology and treatment. Around 470,000 Australians (3.3% of the adult population) are estimated to have 'significant' or 'severe' gambling problems. This project responds to the call for a new framework for theorising and researching problem gambling (Productivity Commission, 1999). Currently, the research literature is characterised by disagreement about definition, causes, and treatment. At the community level, di ....Problem gambling: development and application of a new conceptual framework for aetiology and treatment. Around 470,000 Australians (3.3% of the adult population) are estimated to have 'significant' or 'severe' gambling problems. This project responds to the call for a new framework for theorising and researching problem gambling (Productivity Commission, 1999). Currently, the research literature is characterised by disagreement about definition, causes, and treatment. At the community level, different stakeholder constructions of problem gambling have deadlocked debate. There is a clear need to re-think existing approaches. This project applies an innovative, social-scientific methodology specifically designed to analyse complex, real-world social problems in order to develop a new conceptual framework for understanding and treating problem gambling.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100185
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
Linked data policy hub: connected resources for social research. This project will enable researchers working on complex social and public policy problems to analyse and visualise relationships between documents and data sets from a wide range of sources in order to better understand underlying patterns and trends.