Development Of Iron Complexes For The Treatment Of FriedreichÍs Ataxia & The Role Of Frataxin In Iron Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$616,143.00
Summary
Friedreich's ataxia (FA) is a neuro- & cardio-degenerative disease where there is an accumulation of toxic iron (Fe) in the mitochondrion. Work from our current NHMRC grant showed iron plays a significant role in FA pathology In fact, the CIs dissected the mechanisms of mitochondrial iron-loading & have published 8 papers in high impact journals with 3 papers in PNAS USA in the last 2 yrs Understanding of this process has led to the design of rationalised drugs for FA This work in this Renewal c ....Friedreich's ataxia (FA) is a neuro- & cardio-degenerative disease where there is an accumulation of toxic iron (Fe) in the mitochondrion. Work from our current NHMRC grant showed iron plays a significant role in FA pathology In fact, the CIs dissected the mechanisms of mitochondrial iron-loading & have published 8 papers in high impact journals with 3 papers in PNAS USA in the last 2 yrs Understanding of this process has led to the design of rationalised drugs for FA This work in this Renewal could lead to novel therapies for FARead moreRead less
Quit In General Practice: A Cluster Randomised Trial Of Enhanced In-practice Support For Smoking Cessation
Funder
National Health and Medical Research Council
Funding Amount
$1,117,241.00
Summary
Tobacco smoking remains the most common preventable cause of death and illness in Australia today. Smoking cessation programs are some of the most effective and cost effective strategies that can be undertaken in health care settings, including general practice. This project will test a new approach to supporting smoking cessation in general practice. This involves the practice nurse, GP and Quitline working in partnership to provide a flexible program of suport to meet the needs of smokers.
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less
Beyond Scenarios: Testable Models of the Evolution of Norms. The aim of this project is to investigate the evolution of social norms, and their causal role in social life and its breakdown. It expects to generate new knowledge in this area through the application of new formal techniques to existing hypotheses; especially causal analysis, evolutionary game theory, and phylogenetic cross-cultural testing for empirically plausibility. Expected outcomes include theory development, improved research ....Beyond Scenarios: Testable Models of the Evolution of Norms. The aim of this project is to investigate the evolution of social norms, and their causal role in social life and its breakdown. It expects to generate new knowledge in this area through the application of new formal techniques to existing hypotheses; especially causal analysis, evolutionary game theory, and phylogenetic cross-cultural testing for empirically plausibility. Expected outcomes include theory development, improved research infrastructure and training in collaboration with international partners, and theoretical recommendations for policy intervention. This should allow greater insight and control over the levers of peaceful social life, both in traditional societies, and in large, open, multi-cultural nations like Australia. Read moreRead less
The Indian Roots of Modern Chinese Thought. The Project will strengthen Australia's capacity to interpret and engage with our regional and global environments by demonstrating the need for greater understanding of the nationalistic appeal that Yogâcâra thought has held for Chinese intellectuals; and the rise of New Confucianism as a philosophical movement associated with robust expressions of cultural nationalism. It will also further enhance Australia's international intellectual profile by bri ....The Indian Roots of Modern Chinese Thought. The Project will strengthen Australia's capacity to interpret and engage with our regional and global environments by demonstrating the need for greater understanding of the nationalistic appeal that Yogâcâra thought has held for Chinese intellectuals; and the rise of New Confucianism as a philosophical movement associated with robust expressions of cultural nationalism. It will also further enhance Australia's international intellectual profile by bringing together leading researchers to forge innovative research networks and methodologies to advance the knowledge bases of Chinese intellectual history, Chinese Philosophy and Buddhist Studies, and contribute to building Australian research capacity in these three key areas.Read moreRead less
Changing your mind by changing your brain: An interventionist perspective on cognitive neuroscience. Functional neuroimaging provides a tremendous amount of information about the brain, but what it shows about the mind is less clear. Addressing this fundamental philosophical question requires developing a detailed account of theory-testing in cognitive neuroscience. This project aims to connect neuroimaging to theories of explanation that focus on the way one variable can make a difference to an ....Changing your mind by changing your brain: An interventionist perspective on cognitive neuroscience. Functional neuroimaging provides a tremendous amount of information about the brain, but what it shows about the mind is less clear. Addressing this fundamental philosophical question requires developing a detailed account of theory-testing in cognitive neuroscience. This project aims to connect neuroimaging to theories of explanation that focus on the way one variable can make a difference to another. By linking neuroimaging to facts about manipulable relationships between the brain and the mind, it will also provide a bridge between neuroimaging and complementary technologies for directly intervening on the brain. This, in turn, will provide a platform from which to explore the theoretical and ethical consequences of direct brain manipulation.Read moreRead less
The Formation and Development of Chinese Philosophy as an Academic Discipline in Twentieth Century China. It is in Australia's national interest to pay close attention to the orientation of intellectual and political currents in China and to how these currents are increasingly merging and interacting. This project will enhance our capacity to interpret and engage with our regional environment by contributing to a clearer understanding of the changing relationship between Chinese intellectual tra ....The Formation and Development of Chinese Philosophy as an Academic Discipline in Twentieth Century China. It is in Australia's national interest to pay close attention to the orientation of intellectual and political currents in China and to how these currents are increasingly merging and interacting. This project will enhance our capacity to interpret and engage with our regional environment by contributing to a clearer understanding of the changing relationship between Chinese intellectual traditions and cultural identity. A commitment to understanding what Chinese philosophy means to China's educated elite also demonstrates a willingness to foster dialogue and communication that is sensitive to the intellectual and cultural traditions which are a source of pride and identity for several of our major regional partners. Read moreRead less
The Intellectual Construction of Confucianism in Contemporary China and Taiwan. Since the 1980s China and Taiwan have witnessed the most sustained resurgence of intellectual interest in Confucianism of the twentieth century. This project will provide the first critical analysis of that revival by addressing the complex interaction of institutional, philosophical and ideological factors, rather than study one or the other in isolation. This will enable us to understand the processes by which Chi ....The Intellectual Construction of Confucianism in Contemporary China and Taiwan. Since the 1980s China and Taiwan have witnessed the most sustained resurgence of intellectual interest in Confucianism of the twentieth century. This project will provide the first critical analysis of that revival by addressing the complex interaction of institutional, philosophical and ideological factors, rather than study one or the other in isolation. This will enable us to understand the processes by which Chinese intellectuals have sought to make Confucianism a viable philosophical and cultural resource in the modern world; and to evaluate how successful they have been in achieving these goals.
Results: One monograph; one edited volume; several essays.
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