Functional Brain Age Measurement In Children And Adolescents
Funder
National Health and Medical Research Council
Funding Amount
$700,433.00
Summary
An important aspect of medicine is measuring the function of the human body. It is often advantageous to convert complex functional measures into simpler, intuitive measures such as 'age'. We can compare functional age to chronological age to diagnose disease. In this project, we will build an estimate of 'brain age' in children and adolescents using recordings of the electrical activity of the brain. We will test this 'brain age' as a diagnostic tool in several neurological disorders.
The Microenvironmental Drivers Of T Cell Regulation In Metastatic Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$1,302,611.00
Summary
COX2 inhibitors are drugs commonly used by cancer patients to relieve pain and inflammation. Using human breast cancer samples and mouse models of breast cancer, we show that pathways targeted by these drugs provide an immunological brake that prevents T cells being activated as strongly as they could be, and which has not been studied. This project is expected to yield important anti-cancer targets that could be used to develop a new class of cancer drugs.