A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
PAST EAST ANTARCTIC ICE SHEET AND GLOBAL SEA-LEVEL VARIATIONS. Unique fossil-bearing, open marine sediments occur inland from the modern Antarctic coastline. These were deposited when a now-glaciated Antarctic basin became a marine embayment, during intervals of significantly reduced ice sheet volume and elevated global sea-level in the past. Urgent palaeontological, sedimentological and geochemical research on these sediments are vital to provide: directly datable in situ evidence for major i ....PAST EAST ANTARCTIC ICE SHEET AND GLOBAL SEA-LEVEL VARIATIONS. Unique fossil-bearing, open marine sediments occur inland from the modern Antarctic coastline. These were deposited when a now-glaciated Antarctic basin became a marine embayment, during intervals of significantly reduced ice sheet volume and elevated global sea-level in the past. Urgent palaeontological, sedimentological and geochemical research on these sediments are vital to provide: directly datable in situ evidence for major ice sheet retreat and global sea-level rise in the past; and quantifiable data concerning the environment during such events; an innovative opportunity to improve predictions of Antarctica's response to global warming and answer international debate about past Antarctic Ice Sheet stability.Read moreRead less
Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100376
Funder
Australian Research Council
Funding Amount
$389,339.00
Summary
The role of mantle plumes in driving plate tectonics and continental margin evolution. Plumes of molten rock rise from deep within the Earth resulting in massive surface eruptions that can lead to global mass extinction events. Despite their size, the role plumes play in driving movements of the continents is poorly understood. This project combines independent global and Australian geological and geophysical data with open software systems to link deep Earth and surface geological processes. Th ....The role of mantle plumes in driving plate tectonics and continental margin evolution. Plumes of molten rock rise from deep within the Earth resulting in massive surface eruptions that can lead to global mass extinction events. Despite their size, the role plumes play in driving movements of the continents is poorly understood. This project combines independent global and Australian geological and geophysical data with open software systems to link deep Earth and surface geological processes. This approach will result in a clearer understanding of how the internal workings of our planet drive, and interact with, surface geological processes. The project will also show how these interactions shape the environmentally important, and resources rich, continental margins and ocean basins.Read moreRead less
Identifying Rare Genetic Variants Conferring Susceptibility To Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$293,898.00
Summary
Recently there has been success in identifying common genetic variants that confer susceptibility to multiple sclerosis. The variants that have been discovered so far have modest effects on risk of disease, and only explain a small proportion of familial aggregation of disease. In this study we aim to identify rarer genetic variants that have stronger effects on risk of disease, using new statistical methods and new methods to sequence very large amounts of DNA.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882854
Funder
Australian Research Council
Funding Amount
$6,000,000.00
Summary
Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shapin ....Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shaping oil and gas deposits, hydrothermal and igneous processes involved in ore genesis, and enhanced understanding of some of the world's largest earthquake- and tsunami-generating processes.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100141
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality c ....High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality changes, pollution histories, recent geomorphological change, land-use change, introduction of invasive species and the occurrence of bushfires. A better understanding of the occurrence and timing of these major environmental issues is of national and regional importance.Read moreRead less